2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. CCL-34

CCL-34 is a Toll-like receptor 4 (TLR4) activator. CCL-34 significantly induced dendritic cell (DC) CD83 expression and IL-12p70 production in a dose-dependent manner, thereby inducing DC maturation. CCL-34 enhanced the allostimulatory activity of DC on naive CD4+CD45+RA+ T cell proliferation and IFN-γ secretion. CCL-34 further induced antigen presentation ability in mice inoculated with doxorubicin-treated colorectal cancer cells. CCL-34 can be used in studies of immune stimulation.

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CCL-34 Chemical Structure

CCL-34 Chemical Structure

CAS No. : 943316-60-7

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CCL-34 Related Antibodies

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Description

CCL-34 is a Toll-like receptor 4 (TLR4) activator. CCL-34 significantly induced dendritic cell (DC) CD83 expression and IL-12p70 production in a dose-dependent manner, thereby inducing DC maturation. CCL-34 enhanced the allostimulatory activity of DC on naive CD4+CD45+RA+ T cell proliferation and IFN-γ secretion. CCL-34 further induced antigen presentation ability in mice inoculated with doxorubicin-treated colorectal cancer cells. CCL-34 can be used in studies of immune stimulation.

IC50 & Target[1]

TLR4

 

Molecular Weight

602.84

Formula

C32H62N2O8
CAS No.
SMILES

CCCCCCCCCCCNC([C@@H](NC(CCCCCCCCCCC)=O)CO[C@H]1O[C@@H]([C@@H]([C@@H]([C@H]1O)O)O)CO)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CCL-34 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CCL-34943316-60-7CCL34CCL 34Toll-like Receptor (TLR)dendritic cell (DC)CD83IL-12p70CD4+CD45+RA+ T cellIFN-γInhibitorinhibitorinhibit

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