2. PROTAC Immunology/Inflammation
  3. Molecular Glues IKZF Family
  4. (1S,2S,3R)-PLX-4545

(1S,2S,3R)-PLX-4545 is the (1S,2S,3R) enantiomer of PLX-4545 (HY-159647). PLX-4545 is an orally active and selective cereblon-based molecular glue degrader of IKZF2 (zinc finger transcription factor Helios). PLX-4545 can reprogram immunosuppressive regulatory T cells into pro-inflammatory effector T cells, thereby enhancing anti-tumor immune responses.

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(1S,2S,3R)-PLX-4545

(1S,2S,3R)-PLX-4545 Chemical Structure

CAS No. : 2892066-42-9

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Other Forms of (1S,2S,3R)-PLX-4545:

(1S,2S,3R)-PLX-4545 Related Antibodies

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IKZF1 IKZF2 IKZF3 IKZF4

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Description

(1S,2S,3R)-PLX-4545 is the (1S,2S,3R) enantiomer of PLX-4545 (HY-159647). PLX-4545 is an orally active and selective cereblon-based molecular glue degrader of IKZF2 (zinc finger transcription factor Helios). PLX-4545 can reprogram immunosuppressive regulatory T cells into pro-inflammatory effector T cells, thereby enhancing anti-tumor immune responses[1].

IC50 & Target[1]

IZKF2

 

Molecular Weight

473.56

Formula

C28H31N3O4
CAS No.
SMILES

O=C([C@H](N(CC1=C2C=CC(O[C@@H]3[C@@H](N4CC(C5=CC=CC=C5)C4)CCCC3)=C1)C2=O)CC6)NC6=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(1S,2S,3R)-PLX-4545 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(1S,2S,3R)-PLX-45452892066-42-9Molecular GluesIKZF FamilyIkaros zinc finger protein familyEnantiomerPLX-4545Pro-inflammatory effectorT cellsAnti-tumorImmune responsesInhibitorinhibitorinhibit

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