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Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

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T cells

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1542

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

135

Biochemical Assay Reagents

176

Peptides

MCE Kits

215

Inhibitory Antibodies

122

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: Nuclear Factor of activated T Cells (NFAT) TREM receptor Programmed Cell Death 4 (PDCD4)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-NP028

Keyhole Limpet Hemocyanin-FITC KLH-FITC	Biochemical Assay Reagents Fluorescent Dye	Inflammation/Immunology
Keyhole Limpet Hemocyanin-FITC induces both T-cell-dependent and T-cell-independent immune responses .

HY-P9947

Efalizumab	Integrin	Others
Efalizumab is a targeted T cell modulator, and is a humanized monoclonal antibody of CD11a, the α subunit of LFA-1. Efalizumab inhibits T cell activation, cutaneous T cell trafficking, and T cell adhesion to keratinocytes, can be used for plaque psoriasis research .

HY-W181026

KLF10-IN-1	Fluorescent Dye	Inflammation/Immunology
KLF10-IN-1 (#48-15) is a KLF10 inhibitor with an IC₅₀ value of 40 μM for KLF10 reporter gene. KLF10-IN-1 can inhibit KLF10-DNA binding and transcriptional activity, block the conversion of CD4+CD25 T cells to CD4+CD25+T regulatory cells, and inhibit the expression of KLF10 target genes. KLF10-IN-1 can be used as a useful mechanistic probe to study KLF10-mediated effects and T regulatory cell biology .

HY-144088

ZYF0033 HPK1-IN-22	MAP4K	Inflammation/Immunology Cancer
ZYF0033 is an orally active inhibitor of the hematopoietic progenitor cell kinase HPK1 with an IC50 of less than 10 nM based on the phosphorylation inhibition of MBP protein. ZYF0033 promotes anti-cancer immune responses and reduces phosphorylation of SLP76 (serine 376). ZYF0033 inhibits tumor growth in the 4T-1 syngeneic mouse model and leads to increased intratumoral infiltration of DCs, NK cells, and CD107a ⁺CD8 ⁺ T cells, but not T cells, PD-1 ⁺CD8 ⁺ T cells, TIM-3 ⁺CD8 ⁺ Infiltration of T cells and LAG3 ⁺CD8 ⁺ T cells was reduced .

HY-P99392

Teclistamab JNJ-7957; JNJ-64007957; Tecvayli	CD3	Cancer
Teclistamab is a human bispecific antibody to BCMA and CD3 that recognizes BCMA on target cells and CD3 on T cells and induces T cell-mediated cytotoxicity leading to T cell activation and subsequent target cell lysis. Teclistamab can be used in studies of diseases related to multiple myeloma (MM) .

HY-131140

BD750 5 Publications Verification	JAK STAT	Inflammation/Immunology Cancer
BD750, an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation, with IC₅₀ values of 1.5 μM and 1.1 μM in mouse and human T cells, respectively .

HY-P99523

Vepsitamab AMG 199	CD3	Cancer
Vepsitamab (AMG 199) is an anti-MUC17/CD3 BiTE antibody that binds to CD3 on T cells and MUC17 expressed on tumor cells, mediates redirected tumor cell lysis, and induces T cell activation and proliferation .

HY-169005

Cbl-b-IN-27	E1/E2/E3 Enzyme	Inflammation/Immunology
Cbl-b-IN-27 is a casitas B-lymphoma proto-oncogene-b (Cbl-b) inhibitor with an IC₅₀ value of 7 nM. Cbl-b-IN-27 is promising for research of effector T cell function, T cell, natural killer (NK) cell and B cell activation regulation .

HY-119527

Conagenin	Endogenous Metabolite	Inflammation/Immunology Cancer
Conagenin is an immunomodulator. Conagenin shows antitumor effects by activation of T cells and increasing antitumor effector cells .

HY-P991318

AR20.5	Mucin	Cancer
AR20.5 is a human monoclonal antibody (mAb) targeting MUC1. AR20.5 increases the number of activated CD8 T cells, CD3+CD4−CD8−(DN) T cells, and mature dendritic cells in pancreatic tumor-bearing mice. AR20.5 can be used in anti-pancreatic cancer immunity research .

HY-P10417

RTDLDSLRTYTL	Integrin	Others Cancer
RTDLDSLRTYTL is an Alpha (v) beta (6) integrin (avb6) inhibitor with high affinity and specificity. RTDLDSLRTYTL binds to avb6 integrin, a peptide sequence that activates cytotoxicity and cytokine production in T cells, such as interferon-gamma. RTDLDSLRTYTL is designed through a chimeric T cell antigen receptor (CAR) so that T cells can be redirected to specifically recognize and attack tumor cells. RTDLDSLRTYTL can be used in the research of cancer immunotherapy and targeted drug development .

HY-126037

(±)-ML 209 1 Publications Verification	ROR	Inflammation/Immunology
(±)-ML 209 (compound 4n), a diphenylpropanamide, is a retinoic acid-related orphan receptor RORγ antagonist with an IC₅₀ of 1.1 μM. (±)-ML 209 inhibits RORγt transcriptional activity with an IC₅₀ of 300 nM in HEK293t cells. (±)-ML 209 inhibits the transcriptional activity of RORγt, but not RORα in cells. (±)-ML 209 selectively inhibits murine Th17 cell differentiation without affecting the differentiation of naïve CD4 ⁺ T cells into other lineages, including Th1 and regulatory T cells .

HY-19486

UR-1505	Nuclear Factor of activated T Cells (NFAT) CD3 CD28 Interleukin Related	Inflammation/Immunology
UR-1505 is a *nuclear factor of activated T cells* (NF-AT) inhibitor. UR-1505 can suppress CD3/CD28** induced T cell proliferation, increase p27 ^KIP levels, and induce G1/S cell cycle arrest. UR-1505 can also inhibit the production of IL-5 and IFN-γ in activated T cells. UR-1505 has immunomodulatory properties and can be used in the study of atopic dermatitis .

HY-P99390

Tepoditamab MCLA 117	CD3	Cancer
Tepoditamab (MCLA-117) is a bispecific monoclonal antibody that binds to CLEC12A of myeloid cells and CD3 of cytotoxic T cells. Among others, CLEC12A is a myeloid differentiation antigen. Tepoditamab (MCLA-117) kills AML leukaemia mother cells and AML leukaemia stem cells, induces T cell-mediated proliferative lysis of AML cells and can be used in acute myeloid leukaemia (AML) research .

HY-P99790

Priliximab CEN 000029; cM-T412	Transmembrane Glycoprotein	Inflammation/Immunology
Priliximab (CEN 000029) is an anti-CD4 humanized monoclonal antibody. Priliximab binds to CD4 on the surface of T cells, resulting in a significant and sustained reduction in circulating CD4 ⁺ T cells. Priliximab can be used in research of rheumatoid arthritis (RA) .

HY-P1089

Cytochrome c-pigeon (88-104) PCC 88-104	Cytochrome P450	Inflammation/Immunology
Cytochrome c-pigeon (88-104) (PCC 88-104) has full stimulatory activity for pigeon cytochrome c-primed T cells from B10.A mice. The I-E ^k-restricted T cell response to Cytochrome c pigeon (pcyt c) is specific for the COOH-terminal sequence 88-104 .

HY-159885

MG-B-28	Apoptosis	Cancer
MG-B-28 is an inhibitor of BTLA-HVEM with an IC₅₀ value of 906 nM. MG-B-28 promotes T-cell activation in a dose-dependent manner by blocking the BTLA-HVEM interaction .

HY-121662

Lenaldekar LDK	Apoptosis	Inflammation/Immunology Cancer
Lenaldekar (LDK) inhibits human and murine T-cell expansiomn. Lenaldekar inhibits autoimmune T cell response. Lenaldekar also induces cancer cell apoptosis. Lenaldekar can be used for T-cell mediated autoimmune diseases research .

HY-P99617

Fianlimab REGN3767	LAG-3	Inflammation/Immunology Cancer
Fianlimab (REGN3767) is a human monoclonal antibody that targets the immune checkpoint receptor LAG-3 on T cells and has anti-tumour activity .

HY-P991232

AMX-818	EGFR	Cancer
AMX-818 is a conditionally active, masked T cell engager (TCE) targeting HER2. AMX-818 demonstrates potent T cell cytotoxicity against HER2-positive tumor cell lines. AMX-818 can also induce tumor regression in vivo. AMX-818 is promising for research of HER2-positive solid tumors .

HY-P991364

Aldastotug PYX-106; BSI-060T	Transmembrane Glycoprotein	Cancer
Aldastotug (PYX-106; BSI-060T) is a human monoclonal antibody (mAb) targeting Siglec-15/CD33L3. Aldastotug reverses Siglec-15-mediated immunosuppression and enhances T-cell proliferation. Aldastotug induces significantly increased levels of IFNγ and TNFα in T cells. Aldastotug can be used in cancer immunity research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P10315

[Gln144]-PLP (139-151) Q144-PLP(139-151)	Transmembrane Glycoprotein	Others
[Gln144]-PLP (139-151) is an experimental antigen used to study T cells respond to both autoantigens and cross-reactive non-autoantigens. [Gln144]-PLP (139-151) activates T cells by binding to T-cell Receptor (TCR), which triggers an immune response. [Gln144]-PLP (139-151) can be used to study the regulation of autoimmune diseases .

HY-P991367

ES004	CD47	Cancer
ES004 is a human monoclonal antibody (mAb) targeting SIRPα/CD172a. ES004 enhances macrophage phagocytosis and induces potent T cell responses to promote tumor killing. ES004 can be used in Solid tumours research .

HY-148174

JNJ-3790339	DGK	Cancer
JNJ-3790339, a Ritanserin (HY-10791) analog, is a potent and selective diacylglycerol kinase (DGKα) inhibitor with an IC₅₀ of 9.6 μM. JNJ-3790339 has induction of toxicity in malignant cells, and improves ability to upregulate T cell activation .

HY-161519

PKM2 activator 7	Pyruvate Kinase	Inflammation/Immunology
PKM2 activator 7 (Compd B4) is a PKM2 activator with the AC₅₀ of 0.144 μM. PKM2 activator 7 suppresses DSS (HY-116282C)-induced colitis by inhibiting T cell growth in mouse colitis model .

HY-108161

LF 1695	Interleukin Related	Others
LF 1695 is an immunomodulator. LF 1695 enhances the proliferative response of T cells by increasing the production of IL2 (interleukin-2) or the expression of the IL2 receptor. LF 1695 also increases CONA-induced inhibitory activity in human lymphocytes. LF 1695 can be used to study the proliferative and inhibitory activity of T cell subpopulations, as well as their role in immune regulation .

HY-162501

Yaddle1	Piezo Channel	Inflammation/Immunology
Yaddle1 is an agonist of the mechano-activated ion channel (Piezo1) with a half-maximal effective concentration (MEC₅₀) of 0.40 μM. Yaddle1 can significantly trigger Ca ²⁺ inflow in T cells and induce T cell activation response. Yaddle1 can be used in the study of vaccine adjuvants .

HY-P991402

BI-1910	TNF Receptor	Cancer
BI-1910 is a human monoclonal antibody (mAb) targeting TNFRSF1B. BI-1910 enhances T cell activation and induces CD8 T cell-dependent anti-tumor effects. BI-1910 can be used in solid tumors research. Recommended isotype control: Human IgG1 lambda, Isotype Control (HY-P99992) .

HY-19344

Lifitegrast 5+ Cited Publications SAR 1118; SHP-606	Integrin	Inflammation/Immunology
Lifitegrast (SAR 1118) is a potent integrin antagonist. Lifitegrast blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast inhibits Jurkat T cell attachment to ICAM-1 with an IC₅₀ of 2.98 nM. Lifitegrast can be used for researching dry eye disease .

HY-19344A

Lifitegrast sodium 5+ Cited Publications SAR 1118 sodium; SHP-606 sodium	Integrin	Inflammation/Immunology
Lifitegrast (SAR 1118) sodium is a potent integrin antagonist. Lifitegrast sodium blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast sodium inhibits Jurkat T cell attachment to ICAM-1 with an IC₅₀ of 2.98 nM. Lifitegrast sodium can be used for researching dry eye disease .

HY-W019721

Cyclosporin D	Nuclear Factor of activated T Cells (NFAT)	Inflammation/Immunology
Cyclosporin D, a metabolite of Cyclosporin A, is a weak immunosuppressant. Cyclosporin D is used as internal standard for quantification of Cyclosporin A . Cyclosporin A is a potent immunosuppressant agent, suppress T cell activation by inhibiting calcineurin and the calcineurin-dependent transcription factors nuclear factor of activated T cells (NFAc) .

HY-P2511

Insulin β Chain Peptide (15-23)	Transmembrane Glycoprotein	Metabolic Disease
Insulin β Chain Peptide (15-23) is one of the earliest antigenic epitopes to which CD8 T-cells respond .

HY-123531

JNJ 10329670	Cathepsin	Inflammation/Immunology
JNJ 10329670 is a potent and selective noncovalent cathepsin S inhibitor with a K_i value of 34 nM for human cathepsin S. JNJ 10329670 blocks invariant chain proteolysis in B cells and dendritic cells, as well as antigen-induced T cell proliferation .

HY-165398

Leucylleucine methyl ester	Others	Others
Leucylleucine methyl ester is a lysosomotropic agent that can be used to eliminate gamma delta T cells in human peripheral blood .

HY-P991192

BI-1808	TNF Receptor	Cancer
BI-1808 is a human IgG1 monoclonal antibody that targets TNFR2by blocking interaction of TNFR2 with ligand TNF-α, confers FcγR-dependent depletion of Treg and mediates expansion of intratumoral CD8 ⁺ T cells .

HY-P991382

SAR-439459	TGF-β Receptor	Cancer
SAR-439459 is a human monoclonal antibody (mAb) targeting TGFB1/TGFβ-1. SAR-439459 blocks TGFβ-mediated pSMAD signaling, and suppression of T cells and NK cells. SAR-439459 has anti-tumor activity .

HY-141549

BPK-21	Others	Inflammation/Immunology
BPK-21, an active acrylamide, suppresses T cell activation through blockade of ERCC3 function. BPK-21 specifically targets C342 in the helicase ERCC3 .

HY-P99129

Anti-Mouse CD8a Antibody (53-6.7) 2 Publications Verification	Transmembrane Glycoprotein	Inflammation/Immunology
Anti-Mouse CD8a Antibody (53-6.7) is an anti-mouse CD8a IgG2a antibody inhibitor derived from host Rat. Anti-Mouse CD8a Antibody (53-6.7) binds to CD8αβ stabilizes a conformation with a higher affinity for interaction with MHC class I. Anti-Mouse CD8a Antibody (53-6.7) induces the phosphorylation and activation of TCR proximal signaling pathway components Lck and ZAP70 in polyclonal memory T cells. Anti-Mouse CD8a Antibody (53-6.7) depletes CD8+ T cells and neutralizes cytokine in mice .

HY-119347

Cirsilineol 3 Publications Verification	IFNAR STAT	Inflammation/Immunology Cancer
Cirsilineol, a natural flavone compound, selectively inhibits IFN-γ/STAT1/T-bet signaling in intestinal CD4 ⁺ T cells. Cirsilineol has potent immunosuppressive and anti-tumor properties. Cirsilineol significantly ameliorates trinitro-benzene sulfonic acid (TNBS)-induced T-cell-mediated experimental colitis in mice .

HY-P991217

EU-103	Transmembrane Glycoprotein	Cancer
EU-103 is a humanized monoclonal antibody targeting V-Set And Immunoglobulin Domain Containing 4 (VSIG4) with a K_D value ranging from 10 ⁻⁷ and 10 ⁻⁹. EU-103 blocks the interaction between VSIG4 and CD8+ T cells, promotes the conversion of M2 macrophages into M1 macrophages, induces the proliferation of CD8+ T cells and the secretion of pro-inflammatory cytokines, thereby inhibiting tumor growth. EU-103 is promising for research of cancers, such as bladder cancer, breast cancer, and colon cancer .

HY-19344R

Lifitegrast (Standard) SAR 1118 (Standard); SHP-606 (Standard)	Reference Standards Integrin	Inflammation/Immunology
Lifitegrast (Standard) is the analytical standard of Lifitegrast. This product is intended for research and analytical applications. Lifitegrast (SAR 1118) is a potent integrin antagonist. Lifitegrast blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast inhibits Jurkat T cell attachment to ICAM-1 with an IC₅₀ of 2.98 nM. Lifitegrast can be used for researching dry eye disease .

HY-P991178

BMS-986156	TNF Receptor	Cancer
BMS-986156 is a fully humanized IgG1 agonist monoclonal antibody agonist corticosteroid-induced tumor necrosis factor receptor-related protein (GITR). BMS-986156 binds to GITR and promotes activation of T effector cells and inactivates T regulatory cells. BMS-986156 is indicated for use in advanced solid tumor studies .

HY-P991329

ASP-1948	Complement System	Cancer
ASP-1948 is a human monoclonal antibody (mAb) targeting NRP1/VEGF165R/CD34. ASP-1948 reverses the suppressive effects of regulatory T cells. ASP-1948 can be used in solid tumors research .

HY-156996

AGI-134	Others	Inflammation/Immunology Cancer
AGI-134 is a fully synthetic alpha-Gal glycolipid. AGI-134 invokes CD8+ T cell-mediated immunity. AGI-134 induces tumor cell destruction and phagocytosis .

HY-101309A

5-(Nonyloxy)tryptamine oxalate	5-HT Receptor	Cancer
5-(Nonyloxy)tryptamine oxalate, a high-affinity agonist for the 5-HTIDβ receptor, with an ED₅₀ value of 68 nM. 5-(Nonyloxy)tryptamine oxalate, exhibits antitumor growth activity in vivo and enhances the ability of T cells to target tumor cells .

HY-P99123

Anti-Mouse CD28 Antibody (37.51) 1 Publications Verification	CD28	Inflammation/Immunology
Anti-Mouse CD28 Antibody (37.51) is an agonistic agonistic CD28-specific antibody derived from the host Syrian Hamster. Anti-Mouse CD28 Antibody (37.51) partially prevents lethal graft-versus-hostdisease (GVHD) by selective depletion of alloreactive T cells in mice .

HY-P991421

W0180	VISTA	Cancer
W0180 is a human IgG1 monoclonal antibody (mAb) targeting VISTA/B7-H5. W0180 has the potential to activate T cells. W0180 can be used in solid tumors research .

HY-P991479

GS-8588	HIV	Cancer
GS-8588 is a human bispecific antibody (bsAb) targeting gp120/Glycoprotein 120. GS-8588 induces T cell activation and cytokine secretion in PWH. GS-8588 can be used in AIDS research .

HY-134932

AA74-1	Ser/Thr Protease	Inflammation/Immunology
AA74-1 is a potent and selective inhibitor of APEH. AA74-1 significantly increases T cells proliferation by blocking the APEH activity .

HY-W019721R

Cyclosporin D (Standard)	Reference Standards Nuclear Factor of activated T Cells (NFAT)	Inflammation/Immunology
Cyclosporin D (Standard) is the analytical standard of Cyclosporin D. This product is intended for research and analytical applications. Cyclosporin D, a metabolite of Cyclosporin A, is a weak immunosuppressant. Cyclosporin D is used as internal standard for quantification of Cyclosporin A . Cyclosporin A is a potent immunosuppressant agent, suppress T cell activation by inhibiting calcineurin and the calcineurin-dependent transcription factors nuclear factor of activated T cells (NFAc) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W019721

Cyclosporin D	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields	Nuclear Factor of activated T Cells (NFAT)
Cyclosporin D, a metabolite of Cyclosporin A, is a weak immunosuppressant. Cyclosporin D is used as internal standard for quantification of Cyclosporin A . Cyclosporin A is a potent immunosuppressant agent, suppress T cell activation by inhibiting calcineurin and the calcineurin-dependent transcription factors nuclear factor of activated T cells (NFAc) .

HY-119347

Cirsilineol 3 Publications Verification	Laburnum anagyroides Medic. Structural Classification Monophenols Flavonoids Classification of Application Fields Flavones Source classification Phenols Plants Compositae Inflammation/Immunology Disease Research Fields	IFNAR STAT
Cirsilineol, a natural flavone compound, selectively inhibits IFN-γ/STAT1/T-bet signaling in intestinal CD4 ⁺ T cells. Cirsilineol has potent immunosuppressive and anti-tumor properties. Cirsilineol significantly ameliorates trinitro-benzene sulfonic acid (TNBS)-induced T-cell-mediated experimental colitis in mice .

HY-77839

Cortodoxone 3 Publications Verification 11-Deoxycortisol; cortexolone; Reichstein's substance S	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology Steroids	Glucocorticoid Receptor Endogenous Metabolite
Cortodoxone (11-Deoxycortisol; cortexolone) is a glucocorticoid steroid hormone and also is a glucocorticoid antagonist. Cortodoxone increases tryptophan oxygenase (TO) activity and induces the secretion of corticosterone. Cortodoxone regulates T cell proliferation and activation .

HY-129055

Isoeleutherin	Quinones Structural Classification Iridaceae Classification of Application Fields Source classification Eleutherine plicata Herb. Plants Naphthalene Quinones Inflammation/Immunology Disease Research Fields	Fungal
Isoeleutherin is a naphthopyran derivative isolated from E. americana Merr. Et Heyne with anti-fungal, anti-viral, and anti-tumor activities. Isoeleutherin plays an important role in selective modulation of T helper cell-mediated immune responses .

HY-77839R

Cortodoxone (Standard) 11-Deoxycortisol (Standard); cortexolone (Standard); Reichstein's substance S (Standard)	Structural Classification Source classification Endogenous metabolite Steroids	Reference Standards Glucocorticoid Receptor Endogenous Metabolite
Cortodoxone (Standard) is the analytical standard of Cortodoxone. This product is intended for research and analytical applications. Cortodoxone (11-Deoxycortisol; cortexolone) is a glucocorticoid steroid hormone and also is a glucocorticoid antagonist. Cortodoxone increases tryptophan oxygenase (TO) activity and induces the secretion of corticosterone. Cortodoxone regulates T cell proliferation and activation .

HY-N3796

Echinulin Echinuline	Alkaloids Microorganisms Classification of Application Fields Source classification Disease Research Fields Inflammation/Immunology Indole Alkaloids	NF-κB
Echinulin (Echinuline) is a cyclic dipeptide carrying a triprenylated indole moiety. Echinulin contributes to the activation of T cell subsets, which leads to NF-κB activation.Echinulin exerts its immune roles by the NF-κB pathway.Echinulin has the potential to serve as a immunotherapeutic agent .

HY-119527

Conagenin	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Endogenous Metabolite
Conagenin is an immunomodulator. Conagenin shows antitumor effects by activation of T cells and increasing antitumor effector cells .

HY-W019721R

Cyclosporin D (Standard)	Structural Classification Natural Products Microorganisms Source classification	Reference Standards Nuclear Factor of activated T Cells (NFAT)
Cyclosporin D (Standard) is the analytical standard of Cyclosporin D. This product is intended for research and analytical applications. Cyclosporin D, a metabolite of Cyclosporin A, is a weak immunosuppressant. Cyclosporin D is used as internal standard for quantification of Cyclosporin A . Cyclosporin A is a potent immunosuppressant agent, suppress T cell activation by inhibiting calcineurin and the calcineurin-dependent transcription factors nuclear factor of activated T cells (NFAc) .

HY-119347R

Cirsilineol (Standard)	Laburnum anagyroides Medic. Structural Classification Monophenols Flavonoids Flavones Source classification Phenols Plants Compositae	Reference Standards IFNAR STAT
Cirsilineol (Standard) is the analytical standard of Cirsilineol. This product is intended for research and analytical applications. Cirsilineol, a natural flavone compound, selectively inhibits IFN-γ/STAT1/T-bet signaling in intestinal CD4+ T cells. Cirsilineol has potent immunosuppressive and anti-tumor properties. Cirsilineol significantly ameliorates trinitro-benzene sulfonic acid (TNBS)-induced T-cell-mediated experimental colitis in mice .

HY-N13614

Centaurein	Structural Classification Flavonoids Flavones Source classification Amburana cearensis (Allemão) A.C.Sm. Plants Compositae	Bacterial IFNAR Nuclear Factor of activated T Cells (NFAT) NF-κB
Centaurein, a flavonoid, is an IFN-γ promoter enhancer. Centaurein up-regulates the activity of NFAT and NF-κB enhancers. Centaurein increases the IFN-γ expression in T and NK cells and the serum IFN-γ level in mice. Centaureidin completely relaxes the contractions in intact rat aortic rings. Centaurein effectively protects mice against Listeria infection ^[1][2][3][4].

HY-101092

QS-21 5 Publications Verification Stimulon	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields	NOD-like Receptor (NLR)
QS-21, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21 stimulates Th2 humoral and Th1 cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21 can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18 .

HY-113962

7α,25-Dihydroxycholesterol 2 Publications Verification 7α,25-OHC	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Steroids	EBI2/GPR183 Endogenous Metabolite
7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholesterol is highly potent at activating EBI2 (EC₅₀=140 pM; K_d=450 pM). 7α, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cells, T cells and dendritic cells .

HY-N10295

Flavipin	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Polyphenols Inflammation/Immunology Disease Research Fields	Aryl Hydrocarbon Receptor
Flavipin is an aryl hydrocarbon receptor (Ahr) agonist that induces the expression of Ahr downstream genes in mouse CD4 ⁺ T cells and CD11b ⁺ macrophages. Flavipin inhibits the stabilizing function of Arid5a on Il23a 3′UTR, a newly identified target mRNA . Flavipin exhibits the DPPH free radical scavenging ability with IC₅₀ value of 7.2 μM, and has potent α-glucosidase inhibition with IC₅₀ value of 33.8 μM .

HY-N12422

A2AAR antagonist 2	Structural Classification Natural Products Liliaceae Source classification Allium cepa L. Plants	Adenosine Receptor
3′-Methoxyfurano[4″,5″:3,4]chalcone (compound 2) is a selective A_2AAR antagonist (IC₅₀=33.5 nM) with high affinity. 3′-Methoxyfurano[4″,5″:3,4]chalcone is also a natural product obtained from the bark of Allium cepa L. 3′-Methoxyfurano[4″,5″:3,4]chalcone can promote T cell activation and can be used in cancer immunity research .

HY-N4053

Heraclenin	Structural Classification Classification of Application Fields Source classification Coumarins Phenylpropanoids Plants Umbelliferae Seriphidium transiliense Inflammation/Immunology Disease Research Fields	Nuclear Factor of activated T Cells (NFAT)
Heraclenin, a natural furanocoumarin, significantly inhibits T cell receptor-mediated proliferation in human primary T cells in a concentration-dependent manner by targeting nuclear factor of activated T-cells (NFAT) .

HY-N4010

Iriflophenone	Iridaceae Classification of Application Fields Thymelaeaceae Source classification Phenols Polyphenols Plants Belamcanda chinensis (Linn.) Redouté Disease Research Fields Aquilaria sinensis (Lour.) Spreng. Cancer	Others
Iriflophenone, isolated from Aquilaria sinensis, stimulates MCF-7 and T-47D human breast cancer cells proliferation .

HY-N12120

Retrofractamide A	Structural Classification Alkaloids Other Alkaloids Source classification Piperaceae Plants Piper retrofractum Vahl	Others
Retrofractamide A is an amide constituent that can be isolated from the fruit of Piper chaba. Retrofractamide A promotes adipogenesis in 3T3-L1 cells .

$Retrofractamide A$

HY-N11648

Ganoderic acid T1	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	Apoptosis Caspase
Ganoderic acid T1 is a deacetylated derivative of Ganoderic acid T. Ganoderic acid T1 attenuates antioxidant defense system and induces apoptosis of cancer cells. Ganoderic acid T1 decreases mitochondrial membrane potential and activates caspase-9 and caspase-3, to trigger apoptosis. Ganoderic acid T1 also increases the generation of intracellular ROS to produce pro-oxidant activities and cytotoxicity .

HY-N11038

Drynachromoside A	Structural Classification Drynaria roosii Nakaike Flavonoids Source classification Polypodiaceae Plants Other Flavonoids	Others
Drynachromoside A is a chromone glycoside. Drynachromoside A has biochemical effects on the osteoblastic (MC3T3-E1 cells) proliferation activities .

HY-125443

Lucialdehyde A	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	Others
Lucialdehydes A is a lanostante-type triterpene aldehydes, isolated from the fruiting bodies of Ganoderma lucidum. Lucialdehydes A shows cytotoxic effects on tumor cells, including Lewis lung carcinoma (LLC), T-47D, Sarcoma 180, and Meth-A tumor cell lines .

HY-N3037

3-O-Acetyl-α-boswellic acid α-Boswellic acid acetate	Other Terpenoids Structural Classification other families Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields	Others
3-O-Acetyl-α-boswellic acid suppresses T cell function .

HY-N15586

Vanilloloside	Structural Classification Source classification Soroseris hookeriana (C. B. Clarke) Stebbins Plants Compositae Saccharides Monosaccharides	Others
Vanilloloside is a compound found in Dendrobium moniliforme. Vanilloloside has the ability to stimulate B cell proliferation and inhibit T cell proliferation in vitro .

HY-N2961

Broussonin B	Structural Classification Source classification Phenols Polyphenols Broussonetia × kazinoki Siebold Plants Moraceae	Others
Broussonin B is a phenolic compound isolated from the stem barks of Broussonetia kanzinoki (Moraceae). Broussonin B inhibits adipocyte differentiation in 3T3-L1 cells .

HY-N14767

Naphthablin	Structural Classification Natural Products Microorganisms Source classification	DNA/RNA Synthesis Bcr-Abl
Naphthablin is a naphthoquinone compound that inhibits Abl oncogene functions. Naphthablin inhibits Abl-induced morphological transformation in v-ablts-NIH3T3 cells and inhibits RNA synthesis .

HY-W008859

Tetrac 1 Publications Verification Tetraiodothyroacetic acid; 3,3',5,5'-Tetraiodothyroacetic acid	Structural Classification Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Endogenous metabolite Disease Research Fields Cancer	Integrin Endogenous Metabolite
Tetrac (Tetraiodothyroacetic acid), a derivative of L-thyroxine (T4), is a thyrointegrin receptor antagonist. Tetrac blocks the actions of T4 and 3,5,3'-triiodo-L-thyronine (T3) at the cell surface receptor for thyroid hormone on integrin αvβ3. Tetra has anti-angiogenic and anti-tumor activities .

HY-113636

Kazinol A	Structural Classification other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	Apoptosis Autophagy Akt AMPK
Kazinol A induces cytotoxic effects in human bladder cancer cells, including the cisplatin-resistant T24R2 .

HY-N10318

Erigeside II Dictamnoside A	Structural Classification Dictamnus dasycarpus Turcz. Source classification Rutaceae Plants Saccharides Monosaccharides	Fungal
Erigeside II is a sesquiterpene glycoside found in the root bark of Dictamnus dasycarpus. Erigeside II stimulates the proliferation of T-cells .

HY-125664

Lucialdehyde B	Triterpenes Structural Classification Microorganisms Classification of Application Fields Terpenoids Disease Research Fields Cancer	Antibiotic
Lucialdehyde B is a tetracyclic triterpene isolated from the substrates of Ganoderma lucidum with antiviral and cytotoxic activities. Lucialdehyde B has cytotoxic effects against Lewis lung cancer (LLC), T-47D, Sarcoma 180 and Meth-A tumor cell lines .

HY-N9737

(−)-Acutumine	Structural Classification Alkaloids Pyrrole Alkaloids Source classification Plants Menispermaceae	Others
(−)-Acutumine is a tetracyclic chloroalkaloid that exhibits selective cytotoxicity to cultured human T cells and memory-enhancing properties in the Wistar rat model .

HY-N14776

11-Demethyltomaymycin	Structural Classification Natural Products Microorganisms Source classification	Antibiotic Bacterial
11-Demethyltomaymycin is an antibiotic. 11-Demethyltomaymycin has antiviral activity against Escherichia coli T₁ and T₃ phages and antibacterial activity against Gram-positive bacteria. In addition, 11-Demethyltomaymycin is cytotoxic to leukemia L1210 cells .

HY-P0260

p2Ca	Structural Classification Natural Products Animals Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields	Others
p2Ca, an 8-mer peptide, is a ligand that is naturally processed and presented to the Ld-alloreactive T cell clone, 2C.

HY-N1726

cis-Burchellin	Structural Classification Piper wightii Miq. Source classification Lignans Piperaceae Phenylpropanoids Plants	Others
cis-Burchellin is a bioactive neolignan with anti-allergic activity. cis-Burchellin inhibits IL-2 production in Jurkat T-cells .

HY-145491

Resolvin D5	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	ERK NF-κB
Resolvin D5 is a prolytic mediator (SPM) with anti-inflammatory activity derived from oxidized lipids DHA. Resolvin D5 inhibits Th17 cell differentiation and promotes regulatory T cell differentiation, and inhibits CD4+ T cell proliferation. Resolvin D5 attenuates osteoclast differentiation and interferes with osteoclastogenesis. Resolvin D5 also regulates ERK phosphorylation and nuclear translocation of NF-kappaB. Resolvin D5 could be used in rheumatoid arthritis research .

HY-N4171

Dihydrocucurbitacin B	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields	Apoptosis
Dihydrocucurbitacin B, a triterpene isolated from Cayaponia tayuya roots, inhibits nuclear factor of activated T cells (NFAT), induces cell cycle arrested in the G0 phase, and inhibits delayed type hypersensitivity .

HY-104026B

L-Kynurenine sulfate	Structural Classification Alkaloids Human Gut Microbiota Metabolites Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite Aryl Hydrocarbon Receptor
L-Kynurenine sulfate, an aryl hydrocarbon receptor (AHR) agonist that activates AHR-directed, naive T cell polarization to the anti-inflammatory Treg phenotype .

HY-N1324

Sanggenon N	Structural Classification Flavanonols Flavonoids Source classification Phenols Polyphenols Plants Moraceae Morus alba Linn.	Others
Sanggenon N is an isoprenylated flavonoid that can be isolated from the root bark of Morus alba.Sanggenon N has hepatoprotective activities on t-BHP-induced cell cytotoxicity in HepG2 cells with an EC₅₀ of 23.45 μM .

HY-N14021

Petasites japonicus extract	Structural Classification Natural Products Source classification Plants Compositae Piptadenia Benth.	DNA/RNA Synthesis
Petasites japonicus extract is the extract from Petasites japonicus with antioxidant, anti-inflammatory, anti-obesity, neuroprotective and anti-cancer effects. Petasites japonicus extract promotes osteoblast differentiation via up-regulation of Runx2 and Osterix in MC3T3-E1 cells .

HY-N7122

Thymopentin	Structural Classification Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
Thymopentin is a biologically active peptide secreted mainly by the epithelial cells of thymic cortex and medulla. Thymopentin is an effective immunomodulatory agent with a short plasma half-life of 30 seconds. Thymopentin enhances the generation of T-cell lineage derived from human embryonic stem cells (hESCs) .

HY-N7122A

Thymopentin acetate	Structural Classification Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
Thymopentin acetate is a biologically active peptide secreted mainly by the epithelial cells of thymic cortex and medulla. Thymopentin acetate is an effective immunomodulatory agent with a short plasma half-life of 30 seconds. Thymopentin acetate enhances the generation of T-cell lineage derived from human embryonic stem cells (hESCs) .

HY-113042

Prostaglandin B2	Cardiovascular Disease Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Endocrinology	Endogenous Metabolite
Prostaglandin B2 is a prostaglandin. Prostaglandin B2 is the main substance in cord blood mesenchymal stem cells, to inhibit DC-T Cell proliferation. Prostaglandin B2 also induces cutaneous vasoconstriction of the canine hind paw .

HY-N7038

Phytohemagglutinin 4 Publications Verification PHA-M	Structural Classification Natural Products Classification of Application Fields Leguminosae Glycine max (L.) merr Source classification Plants Inflammation/Immunology Disease Research Fields	Others
Phytohemagglutinin (PHA-M), the major seed lectin of the common bean, Phaseolus vulgaris, accumulates in the parenchyma cells of the cotyledons. Phytohemagglutinin is a T-cell activator. Stimulation of human mononuclear leukocytes by Phytohemagglutinin induces the expression of ChAT mRNA, and potentiated ACh synthesis .

HY-N9753

Tsukubamycin B	Structural Classification Natural Products Source classification Endogenous metabolite	Others
Tsukubamycin B is discovered from Streptomyces tsukubaensis and exhibits immunosuppressive activity by inhibiting T-cell activation. Tsukubamycin B can be used for immune rejection reaction research .

HY-N7572

Eupatoriopicrin	Saussurea costus (Falc.) Lipsch. Structural Classification Terpenoids Sesquiterpenes Source classification Plants Compositae	Parasite
Eupatoriopicrin is an antitrypanosomic agent with an IC₅₀ value of 1.2 μM (T. b. rhodesiense). Eupatoriopicrin is cytotoxic to L6 cells with an IC₅₀ value of 1.6 μM .

HY-101112

Okicenone	Structural Classification Microorganisms Source classification Phenols Polyphenols	HuR
Okicenone is a Hu protein R (HuR) inhibitor. Okicenone inhibits HuR oligomerization, interferes with HuR RNA binding, HuR trafficking, cytokine expression and T-cell activation .

HY-N7661

4β-Hydroxywithanolide E	Source classification Plants Solanaceae Steroids	PPAR
4β-Hydroxywithanolide E, isolated from Physalis peruviana L., inhibits adipocyte differentiation of 3T3-L1 cells through modulation of mitotic clonal expansion. 4β-Hydroxywithanolide E is an adipogenesis inhibitor and inhibits PPARγ, C/EBPα, and the adipocyte-specific molecule aP2 mRNA expression .

HY-N6734

K-252b	Infection Alkaloids Microorganisms Classification of Application Fields Source classification Disease Research Fields Indole Alkaloids	PKC
K-252b, an indolocarbazole isolated from the actinomycete Nocardiopsis, is a PKC inhibitor. K-252b can be used to inhibit extracellular kinases of cells in culture because it can’t pass through cell membrane freely .

HY-N0454

DL-Arginine 4 Publications Verification	Cardiovascular Disease Structural Classification Classification of Application Fields Source classification Amino acids Endogenous metabolite Disease Research Fields	Endogenous Metabolite
DL-Arginine is the racemic compound of L-Arginine (HY-N0455) and D-Arginine (HY-W016781). Arginine is an essential amino acid that requires additional supplementation in traumatic or diseased conditions. Arginine is involved in T cell activation, proliferation, and differentiation, and affects the function of immune cells .

HY-N12960

Artobiloxanthone	Structural Classification Source classification Phenols Polyphenols Plants Moraceae Artocarpus altilis (Parkinson) Fosberg	Apoptosis Bcl-2 Family Caspase COX MMP STAT
Artobiloxanthone (Compound AA3) exhibits antitumor activity, particularly against oral squamous cell carcinoma (OSCC). Artobiloxanthone inhibits Akt/mTOR pathway and STAT3 pathway, inhibits proliferation of SAS and T.Tn (with IC₅₀ of 11 and 22 μM), and inhibits the cancer cell migration. Artobiloxanthone arrests cell cycle at S phase, and induces apoptosis in OSCC cells through activation of caspase 3/9 .

HY-N13160

Sanggenon F	Structural Classification Flavonoids Flavonones Source classification Plants Moraceae Morus alba Linn.	NO Synthase
Sanggenon F is a flavonoid compound derived from Morus alba var. multicaulis. It inhibits the differentiation of 3T3-L1 adipocytes and the production of nitric oxide (NO) in RAW264.7 cells induced by lipopolysaccharides (HY-D1056) and IFN-γ (IC₅₀ of 19 nM). Sanggenon F has potential application value in the fields of anti-inflammatory and metabolic diseases .

HY-N15574

Saringosterol	Structural Classification Natural Products Marine algae Marine natural products Source classification	LXR Bacterial
Saringosterol is found in Sargassum muticum. Saringosterol is a LXR agonist that lowers cholesterol. saringosterol inhibits the mRNA and protein expression of peroxisome proliferator-activated receptor γ and CCAAT enhancer-binding protein α in 3T3-L1 cells. Saringosterol has anti-Mycobacterium tuberculosis activity. Saringosterol can be used in anti-obesity and anti-atherosclerosis research .

Cat. No.	Product Name	Chemical Structure

HY-B0172AS

Isoallolithocholic acid-d2
Isoallolithocholic acid-d₂ is the deuterium labeled Isoallolithocholic acid (HY-B0172A). Isoallolithocholic acid is a T cell regulator and enhances regulatory T cells (Tregs) differentiation .

HY-149773S

HPK1-IN-40-d2
HPK1-IN-40 (compound 49) is a potent and selective HPK1 inhibitor with an IC₅₀ of 0.9 nM. HPK1-IN-40 reinvigorates T-cell receptor (TCR) signaling, promoting T-cell function and cytokine production in T cells while having anti-cancer activity .

HY-B0172AS1

Isoallolithocholic acid-d4
Isoallolithocholic acid-d₄ (3β-Hydroxy-5α-cholanic acid-d₄) is deuterium labeled Isoallolithocholic acid. Isoallolithocholic acid (3β-Hydroxy-5α-cholanic acid), a derivative of Lithocholic acid (HY-10219), is a T cell regulator. Isoallolithocholic acid enhances regulatory T cells (Tregs) differentiation .

HY-141582S

Ceramide 3-d3

Ceramide 3-d₃ (N-Stearoyl phytosphingosine-d₃) is deuterium labeled Ceramide 3. C18 Phytoceramide (t18:0/18:0) (Cer(t18:0/18:0)) is a bioactive sphingolipid found in the stratum corneum of Saccharomyces cerevisiae, wheat grain, and mammalian epidermis. Cer(t18:0/18:0) consists of a phytosphingosine backbone amine linked to a C18 fatty acid chain. Cer(t18:0/18:0) has the function of regulating apoptosis, cell differentiation, proliferation of smooth muscle cells and inhibition of mitochondrial respiratory chain. It also suppresses the expression of allergic cytokines IL-4, TNF-α, and transcription factors c-Jun and NF-κB in histone-stimulated mouse skin tissue. Formulations containing cer(t18:0/18:0) have been used as skin protectants in cosmetics as they reduce water loss and prevent epidermal dehydration and irritation .

HY-19344S2

Lifitegrast-d4-1

Lifitegrast-d₄-1 is deuterium labeled Lifitegrast. Lifitegrast (SAR 1118) is a potent integrin antagonist. Lifitegrast blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast inhibits Jurkat T cell attachment to ICAM-1 with an IC₅₀ of 2.98 nM. Lifitegrast can be used for researching dry eye disease .

HY-B2046S

Simazine-d10
Simazine-d₁₀ is the deuterium labeled Simazine (HY-B2046). Simazine is a triazine herbicide. Simazine is widely used in agriculture, potted plant and tree production. In addition, Simazine can induce the apoptosis of immune cells in the spleen of mice and inhibit the proliferation of B cells and T cells in mice .

HY-W653718

o-Cresol-d7
o-Cresol-d₇ is the deuterium labeled o-Cresol (HY-156199). o-Cresol sulfate is a biomarker related to CAR T cell-independent and dependent metabolic and inflammatory .

HY-19344S1

Lifitegrast-d6

Lifitegrast-d₆ (SAR 1118-d₆) is deuterium labeled Lifitegrast. Lifitegrast (SAR 1118) is a potent integrin antagonist. Lifitegrast blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast inhibits Jurkat T cell attachment to ICAM-1 with an IC₅₀ of 2.98 nM. Lifitegrast can be used for researching dry eye disease .

HY-19344S

Lifitegrast-d4

Lifitegrast-d₄ (SAR 1118-d₄) is deuterium labeled Lifitegrast. Lifitegrast (SAR 1118) is a potent integrin antagonist. Lifitegrast blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast inhibits Jurkat T cell attachment to ICAM-1 with an IC₅₀ of 2.98 nM. Lifitegrast can be used for researching dry eye disease .

HY-B0852S2

Tebuconazole-d6

Tebuconazole-d₆ is a deuterium labeled Tebuconazole (HY-B0852). Tebuconazole is an orally active agricultural azole fungicide which can also inhibit CYP51 with IC₅₀s of 0.9 and 1.3 μM for Candida albicans CYP51 (CaCYP51) and truncated Homo sapiens CYP51 (Δ60HsCYP51), respectively. Tebuconazole induces lipid accumulation and oxidative stress in HepG2 Cells. Tebuconazole decreases MAC-T cells viability and proliferation, induces ER-stress-mediated apoptosis and increases oxidative stress levels in MAC-T cells .

HY-14171S

Bexarotene-d4
Bexarotene-d₄ is a deuterium labeled Bexarotene (LGD1069). Bexarotene (LGD1069) is a selective retinoid X receptors (RXR) agonist for the treatment of cutaneous T-cell lymphoma .

HY-104026CS

L-Kynurenine-13C10 sulfate hemihydrate
L-Kynurenine- ¹³C10 (sulfate hemihydrate) is the ¹³C labeled L-Kynurenine sulfate. L-Kynurenine sulfate hemihydrate, an aryl hydrocarbon receptor (AHR) agonist that activates AHR-directed, naive T cell polarization to the anti-inflammatory Treg phenotype .

HY-159176

Antitumor agent-183
Antitumor agent-183 (compound 3f) has antitumor activity with metabolic stability. Antitumor agent-183 inhibits cancer cell growth, with IC₅₀s less than 5 nM for A549, HCT116, and HS578T cells. The albumin-bound nanoparticle formulation of Antitumor agent-183 has prolonged retention in the tumor tissues .

HY-104026BS

L-Kynurenine-13C10 sulfate
L-Kynurenine-13C10 (sulfate) is the 13C labeled L-Kynurenine sulfate. L-Kynurenine sulfate, an aryl hydrocarbon receptor (AHR) agonist that activates AHR-directed, naive T cell polarization to the anti-inflammatory Treg phenotype .

HY-B0190S1

Nafamostat formate salt-13C6
Nafamostat formate salt- ¹³C₆ is the ¹³C labeled Nafamostat. Nafamostat, a synthetic serine protease inhibitor, is an anticoagulant. Nafamostat supresses T cell auto-reactivity by decreasing granzyme activity and CTL cytolysis. Nafamostat blocks activation of SARS-CoV-2 .

HY-N7819S

Pristane-d40
Pristane-d₄₀ is the deuterium labeled Pristane . Pristane (Norphytane) is a naturally occurring hydrocarbon oil found in small quantities in many plants, in various marine organisms, and as the most active component of mineral oil . Pristane is a non-antigenic adjuvant, and induces MHC class II-restricted, arthritogenic T cells in the rat .

HY-15440AS

Fostemsavir-d8
Fostemsavir-d₈ (BMS-663068-d₈) is deuterium labeled Fostemsavir. Fostemsavir (BMS-663068) is the phosphonooxymethyl prodrug of BMS-626529. Fostemsavir (BMS-663068) is a novel attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4 ⁺ T cells.

HY-W653985

Cortodoxone-d7
Cortodoxone-d₇ (11-Deoxycortisol-d₇) is a deuterium labeled Cortodoxone (HY-77839). Cortodoxone (11-Deoxycortisol; cortexolone) is a glucocorticoid steroid hormone and also is a glucocorticoid antagonist. Cortodoxone increases tryptophan oxygenase (TO) activity and induces the secretion of corticosterone. Cortodoxone regulates T cell proliferation and activation .

HY-B0199S

Mycophenolate Mofetil-d4

Mycophenolate Mofetil-d₄ is the deuterium labeled Mycophenolate Mofetil. Mycophenolate mofetil (RS 61443) is the morpholinoethylester proagent of Mycophenolic acid. Mycophenolate mofetil inhibits de novo purine synthesis via the inhibition of inosine monophosphate dehydrogenase (IMPDH). Mycophenolate mofetil shows selective lymphocyte antiproliferative effects involve both T and B cells, preventing antibody formation .

HY-N7844S

N6-Benzyladenosine-d5
N6-Benzyladenosine-d₅ (Benzyladenosine-d₅) is deuterium labeled N6-Benzyladenosine. N6-Benzyladenosine is an adenosine receptor agonist, has a cytoactive activity. N6-Benzyladenosine arrests cell cycle at G0/G1 phase and induces cell apoptosis. N6-Benzyladenosine also exerts inhibitory effect on T. gondii adenosine kinase and glioma .

HY-13757AS1

Tamoxifen-d3

Tamoxifen-d₃ is the deuterium labeled Tamoxifen . Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells . Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively . Tamoxifen activates autophagy and induces apoptosis . Tamoxifen also can induce gene knockout of CreER(T2) transgenic mouse .

HY-A0003S

Lenalidomide-d5

Lenalidomide-d₅ is deuterium labeled Lenalidomide. Lenalidomide (CC-5013), a derivative of Thalidomide, acts as molecular glue. Lenalidomide is an orally active immunomodulator. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide (CC-5013) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells .

HY-14171S2

Bexarotene-13C6

Bexarotene- ¹³C₆ (LGD1069- ¹³C₆) is ¹³C labeled Bexarotene. Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC₅₀s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC₅₀ >10000 nM) . Bexarotene can be used for the research of cutaneous T-cell lymphoma.

HY-117433S

4-Hydroperoxy Cyclophosphamide-d4

4-Hydroperoxy Cyclophosphamide-d₄ is the deuterium labeled 4-Hydroperoxy cyclophosphamide. 4-Hydroperoxy cyclophosphamide is the active metabolite form of the proagent Cyclophosphamide. 4-Hydroperoxy cyclophosphamide crosslinks DNA and induces T cell apoptosis independent of death receptor activation, but activates mitochondrial death pathways through production of reactive oxygen species (ROS). 4-Hydroperoxy cyclophosphamide has the potential for lymphomas and autoimmune disorders .

HY-A0003S2

Lenalidomide-13C5,15N

Lenalidomide- ¹³C₅, ¹⁵N is ¹⁵N and ¹³C labeled Lenalidomide (HY-A0003). Lenalidomide (CC-5013), a derivative of Thalidomide, acts as molecular glue. Lenalidomide is an orally active immunomodulator. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide (CC-5013) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells .

HY-A0003S3

Lenalidomide-d4

Lenalidomide-d₄ (CC-5013-d₄) is deuterium labeled Lenalidomide. Lenalidomide (CC-5013), a derivative of Thalidomide, acts as molecular glue. Lenalidomide is an orally active immunomodulator. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide (CC-5013) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells .

HY-13757S

Tamoxifen-d3 hydrochloride

Tamoxifen-d₃ hydrochloride is deuterated labeled Tamoxifen (Citrate) (HY-13757). Tamoxifen Citrate (ICI 46474) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells .Tamoxifen Citrate is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen Citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC₅₀ of 0.1 μM and 1.8 μM, respectively . Tamoxifen Citrate activates autophagy and induces apoptosis .Tamoxifen Citrate also can induce gene knockout of CreER(T2) transgenic mouse .

HY-W777169

Bexarotene-13C4
Bexarotene- ¹³C₄ (LGD1069- ¹³C₄) is the ¹³C-labeled Bexarotene (HY-14171). Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC₅₀s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC₅₀ >10000 nM) . Bexarotene can be used for the research of cutaneous T-cell lymphoma.

HY-126855S

Cholic acid 7-sulfate-d4

Cholic acid 7-sulfate-d₄ (7-Sulfocholic acid-d₄) is the deuterium labeled Cholic acid 7-sulfate (HY-126855). Cholic acid 7-sulfate is a selective agonist targeting TGR5 (EC₅₀=0.17 μM) and a ligand for MHC class I-related protein (MR1). As a gut-restricted TGR5 agonist, cholic acid 7-sulfate binds to TGR5 on enteroendocrine L cells, induces GLP-1 secretion, and improves glucose tolerance in a TGR5-dependent manner. Cholic acid 7-sulfate also acts as an endogenous ligand for MR1, promoting the survival of mucosal-associated invariant T cells MAIT and the expression of homeostatic gene signatures, affecting MAIT cell development and function. Cholic acid 7-sulfate is mainly used in the research of diabetes and MAIT cell-related immune regulation .

HY-B1456AS

Fenoprofen-13C6 sodium hydrate

Fenoprofen- ¹³C₆ (LILLY-53858- ¹³C₆) sodium hydrate is the ¹³C labeled Fenoprofen (HY-B1456A).Fenoprofen (LILLY-53858) is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits cyclooxygenase (COX). Fenoprofen is a melanocortin receptors (MCRs) positive allosteric modulator (PAM). Fenoprofen also increases ERK1/2 activation in HEK293T cells. Fenoprofen has anti-arthritic activities and can be used for the study of rheumatoid arthritis and osteoarthritis .

HY-B0847S1

Propiconazole-d3 nitrate

Propiconazole-d₃ (nitrate) is the deuterium labeled Propiconazole nitrate. Propiconazole is a broad-spectrum triazole fungicide that inhibits the conversion of lanosterol to ergosterol, leading to fungal cell membrane disruption. Propiconazole inhibits S. cerevisiae, but not rat liver, microsomal cytochrome P450 (IC50s=0.04 and >200 µM, respectively). Propiconazole inhibits the growth of T. deformans and R. stolonifer (ED50s=0.073 and 4.6 µg/mL, respectively). Propiconazole increases production of reactive oxygen species (ROS).

HY-B0847S

Propiconazole-d7

Propiconazole-d₇ is the deuterium labeled Propiconazole. Propiconazole is a broad-spectrum triazole fungicide that inhibits the conversion of lanosterol to ergosterol, leading to fungal cell membrane disruption. Propiconazole inhibits S. cerevisiae, but not rat liver, microsomal cytochrome P450 (IC₅₀s=0.04 and >200 μM, respectively). Propiconazole inhibits the growth of T. deformans and R. stolonifer (ED50s=0.073 and 4.6 μg/mL, respectively). Propiconazole increases production of reactive oxygen species (ROS) .

HY-78131S3

Ibuprofen-13C6

Ibuprofen- ¹³C₆ ((±)-Ibuprofen- ¹³C₆) is a ¹³C labeled Ibuprofen (HY-78131). Ibuprofen ((±)-Ibuprofen) is a potent, orally active, selective COX-1 inhibitor with an IC₅₀ value of 13 μM. Ibuprofen inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen ((±)-Ibuprofen) can be used in the research of pain, swelling, inflammation, infection, immunology, cancers .

HY-132184S

5,6-Epoxyeicosatrienoic acid-d11

5,6-Epoxyeicosatrienoic acid-d₁₁ (5,6-EET-d₁₁) is deuterium labeled 5,6-Epoxyeicosatrienoic acid. 5,6-Epoxyeicosatrienoic acid (5,6-EET; (±)5,6-EpETrE) is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. In solution, 5,6-Epoxyeicosatrienoic acid degrades into 5,6-DiHET and 5,6-δ-lactone, which can be converted to 5,6-DiHET and quantified by GC-MS. In neuroendocrine cells, such as the anterior pituitary and pancreatic islets, 5,6-Epoxyeicosatrienoic acid has been implicated in the mobilization of calcium and hormone secretion. 5,6-Epoxyeicosatrienoic acid is an inhibitor of T-type voltage-gated calcium channels (Cav3) that inhibits isoforms Cav3.1, Cav3.2 (IC₅₀=0.54 μM), and Cav3. and decreases nifedipine-resistant phenylephrine-induced vasoconstriction in isolated mouse mesenteric arteries via Cav3.2 blockade when used at a concentration of 3 μM. In addition, it is a substrate of COX-1 and COX-2, as measured by oxygen consumption and product formation assays when used at a concentration of 50 μM. (±)5,6-Epoxyeicosatrienoic acid is provided as a mixture of the free acid and lactone .

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