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Results for "

Eps15 Homology Domain (EHD) Protein

" in MedChemExpress (MCE) Product Catalog:

By Targets:	BCL6 (4) Discoidin Domain Receptor (18) EHD Protein (3) Epigenetic Reader Domain (60) PNPLA3 (1) SHP1 (3) SHP2 (2) VISTA (2) WDR5 (13) YTHDF (2) Acyltransferase (1) ADC Antibody (2) ADC Linker (1) ADC Payload (1) Adenylate Cyclase (2) Adrenergic Receptor (1) AIM2 (1) Akt (20) Amino Acid Derivatives (1) Aminoacyl-tRNA Synthetase (3) AMPK (1) Amyloid-β (4) Anaplastic lymphoma kinase (ALK) (2) Androgen Receptor (25) Angiotensin-converting Enzyme (ACE) (8) Antibiotic (6) APC (1) Apolipoprotein (2) Apoptosis (122) Arf Family GTPase (1) Arginase (1) Arrestin (1) Aryl Hydrocarbon Receptor (3) ATF6 (1) Atg8/LC3 (3) ATGL (2) ATM/ATR (1) ATP Citrate Lyase (1) ATP Synthase (1) ATTECs (1) Autophagy (36) Bacterial (16) Bcl-2 Family (24) Bcr-Abl (12) Beta-lactamase (12) Biochemical Assay Reagents (20) BMX Kinase (1) Btk (4) c-Kit (1) c-Met/HGFR (1) c-Myc (4) C-type Lectin-like Receptors (CTLRs) (1) Calmodulin (1) CaMK (5) Cannabinoid Receptor (1) Casein Kinase (2) Caspase (10) CD19 (1) CD20 (1) CD276/B7-H3 (1) CD28 (3) CD3 (4) CD47 (2) CD6 (1) CD73 (1) CDK (19) CFTR (1) Checkpoint Kinase (Chk) (1) CHIKV (1) Chloride Channel (2) CMV (2) Collagen (1) Complement System (3) Connective Peptide (1) COX (2) CTLA-4 (2) Cytochrome P450 (4) DAGL (2) Deubiquitinase (6) DNA Alkylator/Crosslinker (2) DNA Methyltransferase (2) DNA-PK (3) DNA/RNA Synthesis (42) DOCK (3) Dopamine Receptor (1) Drug Derivative (2) Drug Intermediate (1) Drug Isomer (3) Drug Metabolite (2) Dynamin (2) E1/E2/E3 Enzyme (8) E3 Ligase Ligand-Linker Conjugates (2) EGFR (56) Endogenous Metabolite (31) Endonuclease (1) Enterovirus (1) Ephrin Receptor (2) Epoxide Hydrolase (1) ERK (6) Estrogen Receptor/ERR (10) FAAH (1) Factor Xa (2) FAK (2) Fat Mass and Obesity-associated Protein (FTO) (1) Fatty Acid Synthase (FASN) (6) Ferroptosis (20) FGFR (5) FKBP (4) Flavivirus (4) FLT3 (4) Fluorescent Dye (7) Fungal (4) G Protein-coupled Receptor Kinase (GRK) (2) GABA Receptor (1) Galectin (4) Gap Junction Protein (2) GCGR (1) Gli (1) GLP Receptor (1) Glutathione Peroxidase (1) Glycosidase (2) HCV (4) HCV Protease (3) HDAC (19) Hedgehog (2) Heme Oxygenase (HO) (1) Hexokinase (1) HIF/HIF Prolyl-Hydroxylase (18) Histone Acetyltransferase (9) Histone Demethylase (10) Histone Methyltransferase (44) HIV (22) HIV Integrase (2) HIV Protease (1) HOXA (1) HSP (13) HSV (1) IAP (12) IFNAR (7) IGF-1R (1) iGluR (18) IKK (1) IKZF Family (2) Influenza Virus (7) Insulin Receptor (3) Integrin (6) Interleukin Related (31) IRE1 (1) Isotope-Labeled Compounds (21) Itk (1) JAK (15) JNK (4) Keap1-Nrf2 (5) Kinesin (1) LDLR (3) Ligands for E3 Ligase (9) Ligands for Target Protein for PROTAC (7) LIM Kinase (LIMK) (1) Liposome (6) LOX-1 (1) LXR (4) MAGL (12) MAP3K (1) MAPKAPK2 (MK2) (2) MARCKS (4) MDM-2/p53 (12) mGluR (5) MicroRNA (3) Mitochondrial Metabolism (2) Mitophagy (1) Mitosis (5) Mixed Lineage Kinase (7) MMP (5) Molecular Glues (4) Monocarboxylate Transporter (1) mRNA (12) mTOR (7) Mucin (2) MyD88 (6) Myosin (1) Na+/H+ Exchanger (NHE) (1) Na+/K+ ATPase (2) nAChR (2) NADPH Oxidase (3) Necroptosis (3) Neprilysin (1) Neuropeptide Y Receptor (1) NF-κB (17) NO Synthase (12) NOD-like Receptor (NLR) (22) Notch (6) Nuclear Factor of activated T Cells (NFAT) (1) Nuclear Hormone Receptor 4A/NR4A (9) Nucleoside Antimetabolite/Analog (1) Orphan Nuclear Receptor (2) P-glycoprotein (2) P-selectin (1) P2Y Receptor (1) p38 MAPK (9) p62 (7) p97 (1) PAK (1) Parasite (9) PARP (5) PCSK9 (3) PD-1/PD-L1 (12) PDGFR (5) PDHK (1) PDI (1) PERK (1) Phosphatase (17) Phosphodiesterase (PDE) (7) PI3K (13) Pim (1) PIN1 (3) PKA (6) PKC (17) PKG (1) Polo-like Kinase (PLK) (4) Poly(ADP-ribose) Glycohydrolase (PARG) (1) Potassium Channel (15) PPAR (14) Pregnane X Receptor (PXR) (1) Prion Protein (1) Prostaglandin Receptor (1) PROTAC Linkers (1) PROTACs (29) Proteasome (3) Proton Pump (4) PSMA (1) Quinone Reductase (3) RAD51 (1) Radionuclide-Drug Conjugates (RDCs) (1) Raf (2) RAR/RXR (1) Ras (10) Reactive Oxygen Species (ROS) (9) Reference Standards (21) RET (1) Reverse Transcriptase (2) Ribosomal S6 Kinase (RSK) (3) RIP kinase (13) ROCK (1) ROR (2) RSV (2) RUNX (4) SARS-CoV (33) SDCBP (4) Ser/Thr Kinase (1) Ser/Thr Protease (3) Small Interfering RNA (siRNA) (16) Smo (4) Sodium Channel (11) Src (13) SRPK (2) STAT (32) STING (2) Survivin (2) TAM Receptor (1) Target Protein Ligand-Linker Conjugates (1) Tau Protein (9) Telomerase (2) TGF-beta/Smad (3) TGF-β Receptor (5) Thrombin (3) Thyroid Hormone Receptor (3) Tim3 (1) TNF Receptor (22) Toll-like Receptor (TLR) (4) Topoisomerase (1) Transferrin Receptor (1) Transmembrane Glycoprotein (12) Trk Receptor (2) TRP Channel (1) TSH Receptor (1) Tyrosinase (2) VAP-1 (1) VD/VDR (1) VEGFR (18) Virus Protease (5) Wnt (5) YAP (5) Zinc Finger Protein (1) β-catenin (2) γ-secretase (3)
By Research Areas:	Cancer (691) Cardiovascular Disease (68) Endocrinology (12) Infection (121) Inflammation/Immunology (192) Metabolic Disease (78) Neurological Disease (129)
Click Chemistry:	PROTAC Synthesis (2) Azide (1) Alkynes (1)
Oligonucleotides:	Pegylated Lipids (3) Nucleoside Analogs (1) Rat Pre-designed siRNA Sets (4) Mouse Pre-designed siRNA Sets (3) mRNA (12) Cationic Lipids (1) Human Pre-designed siRNA Sets (6) siRNA drugs (1) siRNAs (14)

1188

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

198

Peptides

126

Inhibitory Antibodies

Natural
Products

468

Recombinant Proteins

Isotope-Labeled Compounds

235

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: EHD Protein Discoidin Domain Receptor Epigenetic Reader Domain SHP1 SHP2 YTHDF VISTA WDR5 PIKfyve PNPLA3 BCL6

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-19820A

NSC45586 sodium	Akt Ser/Thr Protease	Neurological Disease Cancer
NSC45586 sodium is an inhibitor of *pleckstrin homology* domain and leucine-rich repeat protein phosphatase (PHLPP)*. NSC45586 sodium targets the PP2C phosphatase domain* in PHLPP1 and PHLPP2. NSC45586 sodium can activate AKT in neurons .

HY-RS29012

Eps15 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Eps15 Rat Pre-designed siRNA Set A contains three designed siRNAs for Eps15 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Eps15 Rat Pre-designed siRNA Set A Eps15 Rat Pre-designed siRNA Set A

HY-RS04452

EPS15 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
EPS15 Human Pre-designed siRNA Set A contains three designed siRNAs for EPS15 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

EPS15 Human Pre-designed siRNA Set A EPS15 Human Pre-designed siRNA Set A

HY-RS22489

Eps15 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Eps15 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Eps15 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Eps15 Mouse Pre-designed siRNA Set A Eps15 Mouse Pre-designed siRNA Set A

HY-RS04453

EPS15L1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
EPS15L1 Human Pre-designed siRNA Set A contains three designed siRNAs for EPS15L1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

EPS15L1 Human Pre-designed siRNA Set A EPS15L1 Human Pre-designed siRNA Set A

HY-RS04221

EHD1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) EHD Protein	Others
EHD1 Human Pre-designed siRNA Set A contains three designed siRNAs for EHD1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control. Components EHD1 siRNA-1: 5 nmol (HPLC) EHD1 siRNA-2: 5 nmol (HPLC) EHD1 siRNA-3: 5 nmol (HPLC) siRNA Negative Control: 5 nmol (HPLC) FAM-labeled siRNA Negative Control: 5 nmol (HPLC) GAPDH siRNA Positive Control: 5 nmol (HPLC)

EHD1 Human Pre-designed siRNA Set A

Small Interfering RNA (siRNA) EHD Protein

Others

EHD1 Human Pre-designed siRNA Set A contains three designed siRNAs for EHD1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Components

EHD1 siRNA-1: 5 nmol (HPLC)

EHD1 siRNA-2: 5 nmol (HPLC)

EHD1 siRNA-3: 5 nmol (HPLC)

siRNA Negative Control: 5 nmol (HPLC)

FAM-labeled siRNA Negative Control: 5 nmol (HPLC)

GAPDH siRNA Positive Control: 5 nmol (HPLC)

EHD1 Human Pre-designed siRNA Set A EHD1 Human Pre-designed siRNA Set A

HY-19820

NSC45586	Akt Ser/Thr Protease	Neurological Disease Cancer
NSC45586 is an inhibitor of *pleckstrin homology* domain and leucine-rich repeat protein phosphatase (PHLPP)*. NSC45586 targets the PP2C phosphatase domain* in PHLPP1 and PHLPP2. NSC45586 can activate AKT in neurons .

HY-110013

Terreic acid	Btk Antibiotic	Infection Inflammation/Immunology
Terreic acid, a quinone epoxide antibiotic, acts as an effective Btk inhibitor. Terreic acid blocks the interaction between PKC and the pleckstrin homology domain of Btk. Terreic acid inhibits the binding of GST-BtkPH to PKC in lysates of HMC-1 human mast cells with an IC₅₀ of approximately 100 μM .

HY-RS16299

Ehd4 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Cancer
Ehd4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ehd4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ehd4 Mouse Pre-designed siRNA Set A Ehd4 Mouse Pre-designed siRNA Set A

HY-RS22153

Ehd3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ehd3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ehd3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ehd3 Mouse Pre-designed siRNA Set A Ehd3 Mouse Pre-designed siRNA Set A

HY-RS27238

Ehd2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ehd2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ehd2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ehd2 Rat Pre-designed siRNA Set A Ehd2 Rat Pre-designed siRNA Set A

HY-RS28675

Ehd4 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ehd4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ehd4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ehd4 Rat Pre-designed siRNA Set A Ehd4 Rat Pre-designed siRNA Set A

HY-RS04223

EHD3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
EHD3 Human Pre-designed siRNA Set A contains three designed siRNAs for EHD3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

EHD3 Human Pre-designed siRNA Set A EHD3 Human Pre-designed siRNA Set A

HY-RS28674

Ehd3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA) EHD Protein	Others
Ehd3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ehd3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ehd3 Rat Pre-designed siRNA Set A Ehd3 Rat Pre-designed siRNA Set A

HY-RS04224

EHD4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
EHD4 Human Pre-designed siRNA Set A contains three designed siRNAs for EHD4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

EHD4 Human Pre-designed siRNA Set A EHD4 Human Pre-designed siRNA Set A

HY-RS20726

Ehd2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ehd2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ehd2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ehd2 Mouse Pre-designed siRNA Set A Ehd2 Mouse Pre-designed siRNA Set A

HY-RS04222

EHD2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
EHD2 Human Pre-designed siRNA Set A contains three designed siRNAs for EHD2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

EHD2 Human Pre-designed siRNA Set A EHD2 Human Pre-designed siRNA Set A

HY-151577

*STAT3-SH2 domain* inhibitor 1**	STAT Apoptosis	Cancer
STAT3-SH2 domain inhibitor 1 is a potent Src Homology 2 (SH2) Domain of STAT3 (STAT3-SH2 domain) inhibitor with a K_d value of 1.57 μM. STAT3-SH2 domain inhibitor 1 inhibits STAT3 signaling transduction and transcriptional activation. STAT3-SH2 domain inhibitor 1 induces apoptosis in gastric cancer cells. STAT3-SH2 domain inhibitor 1 can be used in research of cancer .

HY-N2521

Tetramethylcurcumin FLLL31	STAT Apoptosis	Inflammation/Immunology Cancer
Tetramethylcurcumin (FLLL31), derived from curcumin, specifically suppresses the phosphorylation of STAT3 by binding selectively to Janus kinase 2 and the STAT3 Src homology-2 domain. Tetramethylcurcumin exhibits anti-inflammatory and anti-cancer effects .

HY-15369

FPA-124	Akt Apoptosis	Cancer
FPA-124, a cell-permeable copper complex, is a selective Akt inhibitor with an IC₅₀ of 0.1 μM. FPA-124 interacts with both the pleckstrin homology (PH) and the kinase domains of Akt. FPA-124 induces apoptosis .

HY-P9802

*Anti-Spike-RBD Single Domain* mAb** SARS-CoV-2 (2019-nCoV) Single-Domain Antibodies; Humanized Single Domain Antibody	SARS-CoV	Infection
Anti-Spike-RBD Single Domain mAb is a CHO cell derived Alpaca monoclonal VHH-huFc antibody, specifically binds to SARS-CoV-2 RBD with high affinity .

HY-P3279

EPQpYEEIPIYL 1 Publications Verification	Src	Cancer
EPQpYEEIPIYL, a phosphopeptide, is a Src homology 2 (SH2) domain ligand. EPQpYEEIPIYL activates Src family members (e.g. Lck, Hck, Fyn) by binding to SH2 domains .

HY-169960

2DII	mTOR	Cancer
2DII is a potent and selective mTORC2 inhibitor. 2DII selectively binds mSin1 PH domain and decreases the expression of AKT1 phosphorylation .

HY-14722C

NVP-BSK805 trihydrochloride	JAK	Cancer
NVP-BSK805 trihydrochloride trihydrochloride is an ATP-competitive JAK2 inhibitor, with IC₅₀s of 0.48 nM, 31.63 nM, 18.68 nM, and 10.76 nM for JAK2 JH1 (JAK homology 1), JAK1 JH1, JAK3 JH1, and TYK2 JH1, respectively .

HY-14722A

NVP-BSK805 dihydrochloride 3 Publications Verification	JAK	Cancer
NVP-BSK805 dihydrochloride is an ATP-competitive JAK2 inhibitor, with IC₅₀s of 0.48 nM, 31.63 nM, 18.68 nM, and 10.76 nM for JAK2 JH1 (JAK homology 1), JAK1 JH1, JAK3 JH1, and TYK2 JH1, respectively .

HY-14722

NVP-BSK805 3 Publications Verification	JAK	Cancer
NVP-BSK805 is an ATP-competitive JAK2 inhibitor, with IC₅₀s of 0.48 nM, 31.63 nM, 18.68 nM, and 10.76 nM for JAK2 JH1 (JAK homology 1), JAK1 JH1, JAK3 JH1, and TYK2 JH1, respectively .

HY-12063

PHT-427 1 Publications Verification	Akt Apoptosis	Cancer
PHT-247 is an inhibitor of the pleckstrin homology (PH) domain of Akt, and it is also an inhibitor of PDPK1 with K_is of 2.7 µM and 5.2 µM and for Akt and PDPK1, respectively.

HY-P1816

Fibronectin CS1 Peptide	Integrin	Cancer
The connecting segment 1 (CS-1) is a cell attachment domain located in the type III homology connecting segment (IIICS) of fibronectin. Fibronectin CS1 Peptide lacks the Arg-Gly-Asp-containing domain, actively inhibits tumor metastases in spontaneous and experimental metastasis models .

HY-P4998

*Chemotactic Domain* of Elastin**	Biochemical Assay Reagents	Cancer
Chemotactic Domain of Elastin is an elastin-derived peptide with chemotactic effects on certain tumor cells, such as M27 tumor cells. Chemotactic Domain of Elastin can be used in cancer research .

HY-P10521

*Apolipoprotein KV domain* (67-77)**	VEGFR	Cancer
Apolipoprotein KV domain (67-77) is an 11-amino acid peptide identified from the KV domain of human apolipoprotein a (ApoA) with antiangiogenic and antitumor activities. Apolipoprotein KV domain (67-77) targets the angiogenic c-Src/ERK pathway by blocking activation signals received from vascular endothelial growth factor (VEGF). Apolipoprotein KV domain (67-77) can be used in cancer research .

HY-P1195

*PDZ1 Domain* inhibitor peptide**	iGluR	Neurological Disease
PDZ1 Domain inhibitor peptide, a cyclic peptide, incorporates a β-Ala lactam side chain linker and targets the PDZ1 domains of the postsynaptic density protein 95 (PSD-95). PDZ1 Domain inhibitor peptide disrupts the GluR6/PSD-95 interaction and is very efficient in competing against the C terminus of GluR6 for the PDZ1 domain .

HY-159758

EcDHFR/FKBP12 F36V binder-1	Others	Neurological Disease Cancer
EcDHFR/FKBP12 F36V binder-1 (compound 1) is a bifunctional molecule that combines the Escherichia coli dihydrofolate reductase domain (EcDHFR) with the FKBP12 F36V domain .

HY-169534

AKT-IN-26	Akt	Cancer
AKT-IN-26 (Compound 453) is an AKT inhibitor that binds to the Pleckstrin homology (PH) domain of AKT. AKT-IN-26 can be used in research related to AKT pathway-associated cell proliferation and cancer .

HY-P1195A

*PDZ1 Domain* inhibitor peptide TFA**	iGluR	Neurological Disease
PDZ1 Domain inhibitor peptide TFA, a cyclic peptide, incorporates a β-Ala lactam side chain linker and targets the PDZ1 domains of the postsynaptic density protein 95 (PSD-95). PDZ1 Domain inhibitor peptide TFA disrupts the GluR6/PSD-95 interaction and is very efficient in competing against the C terminus of GluR6 for the PDZ1 domain .

HY-P10697A

VH4127 TFA	LDLR	Metabolic Disease
VH4127 TFA is a cyclic peptide targeting the low density lipoprotein receptor (LDLR) with a K_D of 18 nM for hLDLR. VH4127 TFA specifically binds to rodent and human epidermal growth factor (EGF) homology domain of LDLR .

HY-158415

ATPase-IN-4	ATP Synthase EHD Protein	Cancer
ATPase-IN-4 (Compound MS1) inhibits the ATPase activity of *EHD4* (IC₅₀: 0.92 μM). ATPase-IN-4 also inhibits EHD2 enzymatic activity

HY-149452

SJ1008066	Androgen Receptor	Cancer
SJ1008066 is a MAGE-A11 inhibitor with anIC₅₀ of 0.13 μM. SJ 1008066 binds to the MAGE homology domain (MHD) and disrupts MAGE-A11:PCF11 interaction .

HY-P10697

VH4127	LDLR	Metabolic Disease
VH4127 is a cyclic peptide targeting the low density lipoprotein receptor (LDLR) with a K_D of 18 nM for hLDLR. VH4127, bearing non-natural amino acid residues, specifically binds to rodent and human epidermal growth factor (EGF) homology domain of LDLR .

HY-138283

MR837 1 Publications Verification	Histone Methyltransferase	Cancer
MR837 is an inhibitor of NSD2-PWWP1. MR837 can bind with human nuclear receptor binding SET domain protein 2 (PWWP domain) .

HY-168929

SHP1 activator 1	SHP1 Fluorescent Dye Phosphatase STAT Apoptosis	Cancer
SHP1 activator 1 (Compound 3n) is an activator for src homology-2 domain-containing protein tyrosine phosphatase 1(SHP1) with an EC₅₀ of 17.66 μM. SHP1 activator 1 inhibits the proliferation of ABC-DLBCL cells, induces apoptosis by inhibiting STAT3 signaling pathway. SHP1 activator 1 emitts blue and green fluorescence signalis in MDA-MB-231 cell, and can be used as a cell imaging agent .

HY-N12613

Sydowimide A	SHP1 Phosphatase	Inflammation/Immunology
Sydowimide A is a potent inhibitor of Src homology region 2 domain-containing phosphatase-1 (SHP1), T-cell protein tyrosine phosphatase (TCPTP) and leukocyte common antigen (CD45), with IC₅₀ values of 1.5, 2.4 and 18.83 μM, respectively .

HY-P10108

*Hexokinase II VDAC binding domain* peptide, cell-permeable** Hxk2VBD peptide, cell-permeable	Hexokinase	Neurological Disease
Hexokinase II VDAC binding domain peptide (Hxk2VBD peptide) is a cell-permeable hexokinase II VDAC binding domain. Hexokinase II VDAC binding domain peptide inhibits mitochondrial localization of hexokinase 2 (HXK2). Hexokinase II VDAC binding domain peptide inhibits neurotrophic factor-directed axon outgrowth .

HY-P4924

*Tau Peptide (244-274) (Repeat 1 Domain)*	Tau Protein	Neurological Disease
Tau Peptide (244-274) (Repeat 1 Domain) is aTau fragment.

HY-P4927

*Tau Peptide (245-274) (Repeat 1 Domain)*	Tau Protein	Neurological Disease
Tau Peptide (245-274) (Repeat 1 Domain) is aTau fragment.

HY-P4966

*Tau Peptide (306-336) (Repeat 3 Domain)*	Tau Protein	Neurological Disease
Tau Peptide (306-336) (Repeat 3 Domain) is aTau fragment.

HY-155019

Anticancer agent 128	IAP	Cancer
Anticancer agent 128 (compound 1) is an IAP inhibitor that covalently targets the BIR3 domains of XIAP, cIAP1, and cIAP2. Anticancer agent 128 targets the BIR3 domains of XIAP, cIAP1, and cIAP2 with IC₅₀s of 24.9 nM, 19.3 nM, and 10.3 nM, respectively .

HY-141539

SETDB1-TTD-IN-1 5 Publications Verification	Histone Methyltransferase	Cancer
SETDB1-TTD-IN-1 is a potent, selective and endogenous binder competitive ligand of *SET domain* bifurcated protein 1 tandem tudor domain (SETDB1-TTD) that binds to TTD, with a K_d** of 88 nM. SETDB1-TTD-IN-1 increases SETDB1 methyltransferase activity. SETDB1-TTD-IN-1 can be used for the research of biological functions and disease associations of SETDB1-TTD .

HY-W719359

PHT-427-d4	Isotope-Labeled Compounds Apoptosis Akt	Cancer
PHT-427-d₄ is the deuterium labeled PHT-427 (HY-12063). PHT-247 is an inhibitor of the pleckstrin homology (PH) domain of Akt, and it is also an inhibitor of PDPK1 with Kis of 2.7 μM and 5.2 μM and for Akt and PDPK1, respectively.

HY-141539A

SETDB1-TTD-IN-1 TFA 5 Publications Verification	Histone Methyltransferase	Cancer
SETDB1-TTD-IN-1 TFA is a potent, selective and endogenous binder competitive ligand of *SET domain* bifurcated protein 1 tandem tudor domain (SETDB1-TTD) that binds to TTD, with a K_d** of 88 nM. SETDB1-TTD-IN-1 TFA increases SETDB1 methyltransferase activity. SETDB1-TTD-IN-1 TFA can be used for the research of biological functions and disease associations of SETDB1-TTD .

HY-155018

Anticancer agent 127	IAP	Cancer
Anticancer agent 127 (142D6) is an IAP inhibitor that covalently targets the BIR3 domains of XIAP, cIAP1, and cIAP2. Anticancer agent 127 targets the BIR3 domains of XIAP, cIAP1, and cIAP2 with IC₅₀s of 12 nM, 14 nM, and 9 nM, respectively. Anticancer agent 127 has anticancer effects .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2521

Tetramethylcurcumin FLLL31	other families Classification of Application Fields Source classification Phenols Plants Inflammation/Immunology Disease Research Fields	STAT Apoptosis
Tetramethylcurcumin (FLLL31), derived from curcumin, specifically suppresses the phosphorylation of STAT3 by binding selectively to Janus kinase 2 and the STAT3 Src homology-2 domain. Tetramethylcurcumin exhibits anti-inflammatory and anti-cancer effects .

HY-13956R

Pioglitazone (Standard) U 72107 (Standard)	Human Gut Microbiota Metabolites Source classification Endogenous metabolite	Reference Standards PPAR Ferroptosis
Pioglitazone (Standard) is the analytical standard of Pioglitazone. This product is intended for research and analytical applications. Pioglitazone (U 72107) is an orally active and selective PPARγ (peroxisome proliferator-activated receptor) agonist with high affinity binding to the PPARγ ligand-binding domain with EC₅₀ of 0.93 and 0.99 μM for human and mouse PPARγ, respectively. Pioglitazone can be used in diabetes research .

HY-N0135

Tanshinone IIA Maximum Cited Publications 32 Publications Verification Dan Shen ketone	Quinones Classification of Application Fields Terpenoids Labiatae Samanea saman (Jacq.) Merr. Source classification Diterpenoids Plants Naphthalene Quinones Disease Research Fields Cancer	VEGFR
Tanshinone IIA (Tan IIA) is one of the main compositions in the root of Salvia miltiorrhiza Bunge. Tanshinone IIA may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2.

HY-N0170

Indole-3-carbinol 10+ Cited Publications Indole-3-methanol	Alkaloids other families Classification of Application Fields Source classification Plants Endogenous metabolite Disease Research Fields Indole Alkaloids Cancer	NF-κB Aryl Hydrocarbon Receptor E1/E2/E3 Enzyme Endogenous Metabolite
Indole-3-carbinol (I3C) inhibits NF-κB activity and also is an Aryl hydrocarbon receptor (AhR) agonist, and an inhibitor of WWP1 (WW domain-containing ubiquitin E3 ligase 1).

HY-110013

Terreic acid	Microorganisms Source classification	Btk Antibiotic
Terreic acid, a quinone epoxide antibiotic, acts as an effective Btk inhibitor. Terreic acid blocks the interaction between PKC and the pleckstrin homology domain of Btk. Terreic acid inhibits the binding of GST-BtkPH to PKC in lysates of HMC-1 human mast cells with an IC₅₀ of approximately 100 μM .

HY-N12613

Sydowimide A	Natural Products Microorganisms Marine natural products Source classification Marine microorganism	SHP1 Phosphatase
Sydowimide A is a potent inhibitor of Src homology region 2 domain-containing phosphatase-1 (SHP1), T-cell protein tyrosine phosphatase (TCPTP) and leukocyte common antigen (CD45), with IC₅₀ values of 1.5, 2.4 and 18.83 μM, respectively .

HY-N3561

Cedrelone	Triterpenes Terpenoids Source classification Toona ciliata Roem. Plants Meliaceae	Apoptosis
Cedrelone, a limonoid, is a *Phenazine biosynthesis-like domain-containing protein (PBLD)* activator. Cedrelone induces cancer cell apoptosis, and possess antitumor effects .

HY-N7177

Hydroxytanshinone IIA	Quinones Classification of Application Fields Labiatae Source classification Samanea saman (Jacq.) Merr. Plants Naphthalene Quinones Disease Research Fields Cancer	Drug Metabolite VEGFR
Hydroxytanshinone IIA is a hydroxylated metabolite of Tanshinone IIA. Tanshinone IIA may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2 .

HY-122588

Negamycin	Microorganisms Antibiotics Source classification Other Antibiotics	Bacterial
Negamycin is a compound with antibacterial activity that inhibits protein synthesis by binding to the head domain of the bacterial ribosomal small subunit, leading to cell death, and also promotes misreading of near-cognate codons.

HY-N15775

Ace-1	Lipid	Biochemical Assay Reagents
ACe-1 is a ceramide derivative with an azobenzene moiety to allow for optical control of the N-acyl chain. ACe-1 is capable of reversibly switching lipid domains in a raft-like bilayer membrane .

HY-W013049

Docosanoic acid Behenic acid	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite DNA/RNA Synthesis
Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a K_d of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans .

HY-W013049R

Docosanoic acid (Standard)	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite DNA/RNA Synthesis
Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a Kd of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans .

HY-12372

Sanggenon G	Flavonoids Flavonones Source classification Morus alba L. Plants Moraceae	IAP Caspase
Sanggenon G is a cell-permeable and potent inhibitor of X-linked inhibitor of apoptosis protein (XIAP). Sanggenon G binds specifically to the BIR3 domain of XIAP with a binding affinity of 34.26 μM. Sanggenon G enhances caspase activation .

HY-N5024

Gambogenic acid 1 Publications Verification	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Guttiferae Phenols Polyphenols Plants Garcinia hanburyi Hook. f. Disease Research Fields Cancer	Histone Methyltransferase
Gambogenic acid is an active ingredient that can be isolated from gamboge. Gambogenic acid acts as an effective inhibitor of EZH2, specifically and covalently binds to Cys668 within the EZH2-SET domain, and induces EZH2 ubiquitination. Gambogenic acid can be used for the research of cancer .

HY-N0135R

Tanshinone IIA (Standard) Dan Shen ketone (Standard)	Quinones Terpenoids Labiatae Samanea saman (Jacq.) Merr. Source classification Diterpenoids Plants Naphthalene Quinones	Reference Standards VEGFR
Tanshinone IIA (Standard) is the analytical standard of Tanshinone IIA. This product is intended for research and analytical applications. Tanshinone IIA (Tan IIA) is one of the main compositions in the root of Salvia miltiorrhiza Bunge. Tanshinone IIA may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2.

HY-108486

Herbimycin A	Infection Quinones Microorganisms Classification of Application Fields Source classification Benzene Quinones Disease Research Fields	Bacterial Antibiotic
Herbimycin A, an ansamycin antibiotic, acts as a Src family kinase inhibitor. Herbimycin A binds to the SH domain and inhibits the activity of p60 ^v-src and p210 ^BCR-ABL Herbimycin A inhibits Hsp90 and impairs recovery from heat shock. Herbimycin A exhibits antiangiogenic activity in endothelial cells in vitro.

HY-N0460

1-Caffeoylquinic acid 1 Publications Verification	Phyllodium pulchellum (L.) Desv. Classification of Application Fields Source classification Phenols Polyphenols Plants Compositae Disease Research Fields Cancer	NF-κB PD-1/PD-L1
1-Caffeoylquinic acid is an effective NF-κB inhibitor, shows significant binding affinity to the RH domain of p105 with K_i of 0.007 μM . 1-Caffeoylquinic acid has anti-oxidative stress ability . 1-Caffeoylquinic acid is the Inhibitor for PD-1/PD-L1 .

HY-N0170R

Indole-3-carbinol (Standard)	Alkaloids other families Source classification Plants Endogenous metabolite Indole Alkaloids	NF-κB Aryl Hydrocarbon Receptor E1/E2/E3 Enzyme Endogenous Metabolite
Indole-3-carbinol (Standard) is the analytical standard of Indole-3-carbinol. This product is intended for research and analytical applications. Indole-3-carbinol (I3C) inhibits NF-κB activity and also is an Aryl hydrocarbon receptor (AhR) agonist, and an inhibitor of WWP1 (WW domain-containing ubiquitin E3 ligase 1).

HY-134891

HMBPP lithium (E)-4-Hydroxy-3-methyl-but-2-enyl diphosphate lithium	Natural Products Microorganisms Source classification	Nuclear Factor of activated T Cells (NFAT)
HMBPP lithium is an intermediate in isoprenoid biosynthesis that can be produced by bacteria and protozoa that use the non-mevalonate pathway for isoprenoid biosynthesis. HMBPP lithium is a ligand of the internal domain of BTN3A1 and is an activator for human Vγ9/Vδ2 T cells. HMBPP lithium exhibits phagostimulant property in mosquitos .

HY-Y1309

1-Naphthol Furro ER; NSC 9586; Nako TRB	Monophenols Classification of Application Fields Source classification Other Diseases Phenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite
1-naphthol (Furro ER) is an excited state proton transfer (ESPT) fluorescent molecular probe. 1-naphthol can sense the hydrophobic domains in micellar aggregation and accurately sense the sol-gel transition. 1-naphthol can be used to study the thermally induced microenvironmental changes and hydration levels of Pluronic F127 (PF127) in different microenvironments in aqueous media .

HY-N2587

Irigenin	Flavonoids Iridaceae Classification of Application Fields Source classification Phenols Polyphenols Plants Belamcanda chinensis (Linn.) Redouté Disease Research Fields Isoflavones Cancer	Integrin Apoptosis
Irigenin is a is a lead compound, and mediates its anti-metastatic effect by specifically and selectively blocking α9β1 and α4β1 integrins binding sites on C-C loop of Extra Domain A (EDA). Irigenin shows anti-cancer properties. It sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells .

HY-N15264

Azaspirene (-)-Azaspirene	Natural Products Microorganisms Source classification	VEGFR Raf
Azaspirene ((-)-Azaspirene) is an angiogenesis and Raf-1 activation inhibitor isolated from the fungus Neosartorya sp. Azaspirene inhibits vascular endothelial growth factor (VEGF)-induced human umbilical vein endothelial cell (HUVEC) migration and Raf-1 activation, but has no effect on the activation of kinase insert domain-containing receptor/fetal liver kinase 1 (VEGF receptor 2) .

HY-147089

PRRSV/CD163-IN-1	Infection Alkaloids Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Bacterial Endogenous Metabolite
PRRSV/CD163-IN-1 is a PRRSV/CD163 inhibitor. PRRSV/CD163-IN-1 can inhibit the interaction between the PRRSV glycoprotein (GP2a or GP4) and the CD163-SRCR5 domain. PRRSV/CD163-IN-1 can be used for the research of porcine reproductive and respiratory syndrome (PRRS) .

HY-N0460R

1-Caffeoylquinic acid (Standard)	Phyllodium pulchellum (L.) Desv. Source classification Phenols Polyphenols Plants Compositae	Reference Standards NF-κB PD-1/PD-L1
1-Caffeoylquinic acid (Standard) is the analytical standard of 1-Caffeoylquinic acid. This product is intended for research and analytical applications. 1-Caffeoylquinic acid is an effective NF-κB inhibitor, shows significant binding affinity to the RH domain of p105 with K_i of 0.007 μM . 1-Caffeoylquinic acid has anti-oxidative stress ability . 1-Caffeoylquinic acid is the inhibitor for PD-1/PD-L1 .

HY-119906

Conglobatin FW-04-806	Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	HSP Apoptosis
Conglobatin (FW-04-806), a macrolide dilactone, is isolated from the culture of Streptomyces conglobatus. Conglobatin is an orally active Hsp90 inhibitor. Conglobatin can bind to the N-terminal domain of Hsp90 and disrupt Hsp90-Cdc37 complex formation. Conglobatin induces apoptosis in human breast cancer cells and esophageal squamous cell carcinoma cells, and exhibits antitumor activity in vivo .

HY-N2025

Oroxin A 2 Publications Verification	Flavonoids Classification of Application Fields Flavones Source classification Metabolic Disease Bignoniaceae Plants Oroxylum indicum (Linn.) Bentham ex Kurz Disease Research Fields	PPAR Glycosidase
Oroxin A is the major component of an ethanol-water Oroxylum indicum (L.) Kurz (Bignoniaceae) seed extract (OISE). Oroxin A acts as a partial PPARγ agonist that can activate PPARγ transcriptional activation. Oroxin A activates PPARγ by docking into the PPARγ protein ligand-binding domain. Oroxin A also exhibits an inhibitory activity against α-glucosidase and an antioxidant capacity . Oroxin A exerts anti-breast cancer effects by inducing ER stress-mediated senescence .

HY-105231

Bryostatin 1 2 Publications Verification	Anti-inflammation/Immunoregulatory Neurological Disease Classification of Application Fields Marine natural products Source classification Other marine organisms Disease Research Infection Macrolide Antibiotics Animals Antibiotics Anticancer Inflammation/Immunology Disease Research Fields	PKC HIV Bacterial
Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a potent and central nervous system (CNS)-permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domain of Munc13-1 and the full-length Munc13-1 protein with K_is of 8.07 nM and 0.45 nM, respectively. Bryostatin 1 has anti-cancer, anti-inflammatory, neuroprotective, anti-HIV-1 infection properties .

HY-N2587R

Irigenin (Standard)	Flavonoids Iridaceae Source classification Phenols Polyphenols Plants Belamcanda chinensis (Linn.) Redouté Isoflavones	Reference Standards Integrin Apoptosis
Irigenin (Standard) is the analytical standard of Irigenin. This product is intended for research and analytical applications. Irigenin is a is a lead compound, and mediates its anti-metastatic effect by specifically and selectively blocking α9β1 and α4β1 integrins binding sites on C-C loop of Extra Domain A (EDA). Irigenin shows anti-cancer properties. It sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells .

HY-113224

Desmosterol 5 Publications Verification	Microorganisms Classification of Application Fields Source classification Disease markers Endocrine diseases Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite LXR Fatty Acid Synthase (FASN) Interleukin Related Reactive Oxygen Species (ROS) NOD-like Receptor (NLR)
Desmosterol is a cholesterol-like molecule. In the Bloch pathway of cholesterol biosynthesis, Desmosterol is a direct precursor of cholesterol. As an endogenous metabolite, Desmosterol is used to study cholesterol metabolism . Desmosterol is an LXR activator and SREBP inhibitor, which can suppress macrophage inflammasome activation and prevent vascular inflammation and atherosclerosis. A reduction in Desmosterol promotes the production of mitochondrial reactive oxygen species (ROS) in macrophages and pyrin domain-dependent inflammasome activation of NLRP3. Desmosterol holds potential for research in inflammation, metabolism, and cardiovascular diseases .

HY-N15327

Hyrtiosal	Other Terpenoids Animals Terpenoids Source classification	HIV HIV Integrase
Hyrtiosal, found in the marine sponge Hyrtios erectus, is an inhibitor of the N-terminal domain (NTD) of HIV-1 integrase (HIV-1 IN) with an IC₅₀ value of 9.60-0.86 μM. Hyrtiosal binds to the Ser17, Trp19, and Lys34 sites on the NTD of HIV-1 IN, inhibiting the binding of HIV-1 viral DNA to integrase and interfering with the formation of the pre-integrated complex of HIV-1. Hyrtiosal is promising for research of anti-HIV agents .

HY-N1486R

Ursonic acid (Standard) 3-Ketoursolic acid (Standard)	Triterpenes Ziziphus jujuba Terpenoids Source classification Plants Endogenous metabolite Rhamnaceae	Reference Standards Apoptosis Endogenous Metabolite NF-κB
CSRM617 (Standard) is the analytical standard of CSRM617. This product is intended for research and analytical applications. CSRM617 is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor) with a Kd of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. CSRM617 induces apoptosis by appearance of cleaved Caspase-3 and PARP. CSRM617 is well tolerated in the prostate cancer mouse model

HY-N3103

p-Coumaric Acid Ethyl Ester Ethyl (E)-p-hydroxycinnamate; Ethyl trans-4-hydroxycinnamate	Monophenols other families Classification of Application Fields Simple Phenylpropanols Source classification Phenols Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields	Tyrosinase
p-Coumaric Acid Ethyl Ester (Ethyl (E)-p-hydroxycinnamate; Ethyl trans-4-hydroxycinnamate) is a non-competitive, reversible inhibitor of tyrosinase (IC₅₀=4.89 μg/mL, K_i=1.83 μg/mL), which can quench the intrinsic fluorescence of the enzyme. p-Coumaric Acid Ethyl Ester changes the binding affinity of L-tyrosine by inducing conformational changes in the catalytic domain of tyrosinase, and does not bind to the copper ion of the enzyme. p-Coumaric Acid Ethyl Ester is used in the development of medicines, cosmetics and fruit preservation products using pollen .

HY-N2025R

Oroxin A (Standard)	Flavonoids Flavones Source classification Bignoniaceae Plants Oroxylum indicum (Linn.) Bentham ex Kurz	Reference Standards PPAR Glycosidase
Oroxin A (Standard) is the analytical standard of Oroxin A. This product is intended for research and analytical applications. Oroxin A is the major component of an ethanol-water Oroxylum indicum (L.) Kurz (Bignoniaceae) seed extract (OISE). Oroxin A acts as a partial PPARγ agonist that can activate PPARγ transcriptional activation. Oroxin A activates PPARγ by docking into the PPARγ protein ligand-binding domain. Oroxin A also exhibits an inhibitory activity against α-glucosidase and an antioxidant capacity . Oroxin A exerts anti-breast cancer effects by inducing ER stress-mediated senescence .

HY-113329

Guanidinoethyl sulfonate 4 Publications Verification Taurocyamine	Natural Products Other disease Classification of Application Fields Disease markers Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Guanidinoethyl sulfonate (Taurocyamine) is an orally available, blood-brain permeable competitive inhibitor of taurine transporters and a competitive antagonist of glycine receptors (GlyR) (IC₅₀=565 μM). Guanidinoethyl sulfonate has both weak agonist and antagonist effects on GABA_A receptors. Guanidinoethyl sulfonate inhibits taurine transmembrane transport and competitively binds to the GlyR ligand binding domain, thereby blocking glycine-mediated chloride influx, and may regulate brain pH to exert neuroprotective effects. Guanidinoethyl sulfonate can be used for neuroprotection studies of ischemic brain injury .

HY-113224R

Desmosterol (Standard)	Microorganisms Source classification Disease markers Endocrine diseases Endogenous metabolite Steroids	Reference Standards Endogenous Metabolite LXR Fatty Acid Synthase (FASN) Interleukin Related Reactive Oxygen Species (ROS) NOD-like Receptor (NLR)
Desmosterol (Standard) is the analytical standard of Desmosterol. This product is intended for research and analytical applications. Desmosterol is a cholesterol-like molecule. In the Bloch pathway of cholesterol biosynthesis, Desmosterol is a direct precursor of cholesterol. As an endogenous metabolite, Desmosterol is used to study cholesterol metabolism [1]. Desmosterol is an LXR activator and SREBP inhibitor, which can suppress macrophage inflammasome activation and prevent vascular inflammation and atherosclerosis. A reduction in Desmosterol promotes the production of mitochondrial reactive oxygen species (ROS) in macrophages and pyrin domain-dependent inflammasome activation of NLRP3. Desmosterol holds potential for research in inflammation, metabolism, and cardiovascular diseases [1][2][3].

HY-113329R

Guanidinoethyl sulfonate (Standard)	Natural Products Other disease Disease markers Endogenous metabolite	Endogenous Metabolite
Guanidinoethyl sulfonate (Standard) is the analytical standard of Guanidinoethyl sulfonate. This product is intended for research and analytical applications. Guanidinoethyl sulfonate is an orally available, blood-brain permeable competitive inhibitor of taurine transporters and a competitive antagonist of glycine receptors (GlyR) (IC50=565 μM). Guanidinoethyl sulfonate has both weak agonist and antagonist effects on GABAA receptors. Guanidinoethyl sulfonate inhibits taurine transmembrane transport and competitively binds to the GlyR ligand binding domain, thereby blocking glycine-mediated chloride influx, and may regulate brain pH to exert neuroprotective effects. Guanidinoethyl sulfonate can be used for neuroprotection studies of ischemic brain injury .

HY-N6651

Isocryptotanshinone	Quinones Structural Classification Classification of Application Fields Labiatae Samanea saman (Jacq.) Merr. Source classification Plants Naphthalene Quinones Disease Research Fields Cancer	STAT Phosphatase Apoptosis Autophagy p38 MAPK EGFR JAK Bcl-2 Family Survivin Akt mTOR PARP Caspase Atg8/LC3 CDK
Isocryptotanshinone is a dual STAT3 and PTP1B (IC₅₀ = 56.1 μM) inhibitor. Isocryptotanshinone inhibits STAT3 by binding to the STAT3 SH2 domain to block phosphorylation and nuclear translocation ^[1][2]. Isocryptotanshinone exerts its anti-proliferative effect via the induction of cell cycle arrest, apoptosis, and pro-death autophagy, through the regulation of STAT3, AKT/mTOR and MAPK signaling pathways ^[1][3][4]. Isocryptotanshinone suppresses the xenograft gastric cancer (GC) tumor growth in BALB/c nude mice . Isocryptotanshinone can be used for cancer research, such as lung cancer, breast cancer and GC ^[1][3][4].

HY-12316

20(S)-Hydroxycholesterol 2 Publications Verification 20α-Hydroxycholesterol	Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids Cancer	Smo Endogenous Metabolite
20(S)-Hydroxycholesterol (20α-Hydroxycholesterol) is an allosteric activator that selectively targets the Smoothened (Smo) of the Hedgehog pathway with an EC₅₀ of ~30 μM (Hedgehog). 20(S)-Hydroxycholesterol binds to the extracellular *cysteine-rich domain* (CRD) of Smo in a stereoselective manner, activating downstream Gli transcription factors (without inducing transcription of receptor genes in the Wnt pathway). 20(S)-Hydroxycholesterol enhances osteogenic differentiation of bone marrow stromal cells and synergistically activates the Raf/MEK/ERK** pathway with Simvastatin (HY-17502) to promote bone regeneration. 20(S)-Hydroxycholesterol can be used to study the mechanisms of developmental biology, oncology, bone, and angiogenesis .

HY-B1167A

Ajmaline hydrochloride Cardiorythmine hydrochloride; (+)-Ajmaline hydrochloride	Rauvolfia verticillata (Lour.) Baill. Apocynaceae Natural Products Source classification Plants	Others
Ajmaline hydrochloride is a Class Ia antiarrhythmic agent. It inhibits HERG potassium channels with IC50s of 1.0 μmol/l and 42.3 μmol/l in HEK cells and moth spider oocytes respectively. The inhibitory effect of Ajmaline hydrochloride is rapid, reversible, and positive frequency dependent. It acts primarily on the open state of the HERG channel and may also be combined with the inactivated state. The inhibitory effect of ajmaline hydrochloride is dependent on aromatic residues in the S6 domain, and the sensitivity is significantly reduced in the inactivation-deficient HERG S620T channel. It can also slightly affect the activation voltage of HERG channels. Ajmaline hydrochloride's inhibitory effect on HERG channels may contribute to both its potent antiarrhythmic effects and its potential proarrhythmic risk.

HY-N10159

1-Benzyl-I3C	Natural Products Brassica oleracea L. Source classification Plants Brassicaceae	Others
1-Benzyl-I3C is a NEDD4-1 inhibitor with significant anticancer activity. 1-Benzyl-I3C can directly inhibit the ubiquitination activity of NEDD4-1 with an IC50 of 12.3μM, which is significantly better than its precursor compound I3C of 284μM. 1-Benzyl-I3C and its analogs showed good effects in inhibiting the proliferation of human melanoma cells, which is roughly related to their potency as NEDD4-1 enzyme inhibitors. By combining in vitro ubiquitination experiments and thermal stability analysis, 1-Benzyl-I3C was shown to be able to bind to the catalytic HECT domain of NEDD4-1 .

HY-N1431

Tabersonine 3 Publications Verification	Apocynaceae Alkaloids Source classification Plants Indole Alkaloids Catharanthus roseus (L.) G. Don	NOD-like Receptor (NLR) Apoptosis Cytochrome P450 NF-κB PI3K Akt CDK Caspase Interleukin Related p38 MAPK
Tabersonine is a selective, orally active NLRP3 inhibitor. Tabersonine directly binds to the NACHT domain of NLRP3, inhibiting its ATPase activity and oligomerization, thereby blocking ASC spot formation and caspase-1 activation, and reducing the release of pro-inflammatory cytokines such as IL-1β. Tabersonine also inhibits K63-linked ubiquitination of TRAF6, blocking NF-κB, PI3K/Akt, and p38 MAPK signaling pathways. Tabersonine can inhibit inflammatory responses, induce apoptosis of liver cancer cells through mitochondrial pathways and death receptor pathways, reduce mitochondrial membrane potential, promote cytochrome c release, and activate caspase proteins. Tabersonine is mainly used in the study of NLRP3-driven inflammatory diseases (such as acute lung injury, sepsis, peritonitis) and tumors such as liver cancer .

HY-N1431A

Tabersonine hydrochloride	Apocynaceae Alkaloids Source classification Plants Indole Alkaloids Catharanthus roseus (L.) G. Don	NOD-like Receptor (NLR) Apoptosis Cytochrome P450 NF-κB PI3K Akt CDK Caspase Interleukin Related p38 MAPK
Tabersonine hydrochloride is a selective, orally active NLRP3 inhibitor. Tabersonine hydrochloride directly binds to the NACHT domain of NLRP3, inhibiting its ATPase activity and oligomerization, thereby blocking ASC spot formation and caspase-1 activation, and reducing the release of pro-inflammatory cytokines such as IL-1β. Tabersonine hydrochloride also inhibits K63-linked ubiquitination of TRAF6, blocking NF-κB, PI3K/Akt, and p38 MAPK signaling pathways. Tabersonine hydrochloride can inhibit inflammatory responses, induce apoptosis of liver cancer cells through mitochondrial pathways and death receptor pathways, reduce mitochondrial membrane potential, promote cytochrome c release, and activate caspase proteins. Tabersonine hydrochloride is mainly used in the study of NLRP3-driven inflammatory diseases (such as acute lung injury, sepsis, peritonitis) and tumors such as liver cancer .

HY-W017113

2-Mercaptobenzothiazole	Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Aryl Hydrocarbon Receptor
2-Mercaptobenzothiazole is an activator of the aryl hydrocarbon receptor (AhR) , inhibiting thyroid hormone synthesis and dopamine beta-hydroxylase activity . 2-Mercaptobenzothiazole promotes bladder cancer cell invasion by altering the conformation of the AhR ligand binding domain (LBD), activating AhR transcription, and upregulating the mRNA and protein expression of target genes CYP1A1 and CYP1B1 . 2-Mercaptobenzothiazole inhibits thyroid peroxidase (TPO) with an IC₅₀ value of 11.5 μM, induces histological changes such as follicular cell hypertrophy in Xenopus laevis tadpoles, delaying metamorphosis . 2-Mercaptobenzothiazole increases chromosomal aberrations and sister chromatid exchanges (SCEs) in Chinese hamster ovary (CHO) cells, and enhances carcinogenicity in F344/N rats . 2-Mercaptobenzothiazole inhibits norepinephrine synthesis in mice and completely blocks the conversion of exogenous dopamine to norepinephrine in rat cardiomyocytes .

HY-N15378

β-Carotene-15,15'-epoxide	Natural Products Source classification Spondias mombin L. Plants Anacardiaceae	IAP Bcl-2 Family COX TNF Receptor Caspase Apoptosis
β-carotene-15,15ʹ-epoxide is a XIAP antagonist with apoptosis-inducing and antitumor activity, found in the leaves of Spondias mombin. In a DMBA (HY-W011845)-induced rat model of breast cancer, β-carotene-15,15ʹ-epoxide binds to the BIR3 domain of the anti-apoptotic protein XIAP, blocking its interaction with caspase-9 and thereby promoting tumor cell apoptosis. In addition, β-carotene-15,15ʹ-epoxide significantly downregulates the expression of BCL-2, COX-2, and TNF-α in tumor tissues, reduces MDA levels, increases catalase activity, and modulates serum levels of LDH, ALP, and ALT, demonstrating strong antioxidant, anti-inflammatory, and metabolic protective effects. β-carotene-15,15ʹ-epoxide may be used in research on inflammation-related conditions and cancers such as breast cancer .

HY-N0086R

N6-Methyladenosine (Standard) 6-Methyladenosine (Standard); N-Methyladenosine (Standard)	Natural Products Microorganisms Source classification Endogenous metabolite	Endogenous Metabolite Influenza Virus Reference Standards
N6-Methyladenosine (Standard) is the analytical standard of N6-Methyladenosine. This product is intended for research and analytical applications. N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities. In Vitro: N6-methyladenosine (m6A) is selectively recognized by the human YTH domain family 2 (YTHDF2) protein to regulate mRNA degradation. N6-methyladenosine (m6A), a prevalent internal modification in the messenger RNA of all eukaryotes, is post-transcriptionally installed by m6A methyltransferase (e.g., MT-A70) within the consensus sequence of G(m6A)C (70%) or A(m6A)C (30%). N6-methyladenosine (m6A)-containing RNAs are greatly enriched in the YTHDF-bound portion and diminished in the flow-through portion . N6-methyladenosine (m6A), the most abundant internal RNA modification, functions in diverse biological processes, including regulation of embryonic stem cell self-renewal and differentiation. N6-methyladenosine (m6A) is a large protein complex, consisting in part of methyltransferase-like 3 (METTL3) and methyltransferase-like 14 (METTL14) catalytic subunits .

Cat. No.	Product Name	Chemical Structure

HY-13956S

Pioglitazone-d4
Pioglitazone-d₄ is a deuterium labeled Pioglitazone. Pioglitazone (U 72107) is a potent and selective PPARγ agonist with high affinity binding to the PPARγ ligand-binding domain with EC₅₀ of 0.93 and 0.99 μM for human and mouse PPARγ, respectively .

HY-117287

Deucravacitinib

30+ Cited Publications

Deucravacitinib (BMS-986165) is a highly selective, orally bioavailable allosteric TYK2 inhibitor for the treatment of autoimmune diseases, which selectively binds to TYK2 pseudokinase (JH2) domain (IC₅₀=1.0 nM) and blocks receptor-mediated Tyk2 activation by stabilizing the regulatory JH2 domain. Deucravacitinib inhibits IL-12/23 and type I IFN pathways. Deucravacitinib, the FDA's world first de novo deuterium, is available for study in moderate to severe plaque psoriasis .

HY-126242S

Tyk2-IN-7

Tyk2-IN-7 is an orally active TYK2 JH2 inhibitor, binds to TYK2 JH2 domain with IC₅₀ and K_i.app of 0.00053 μM and 0.00007 μM, respectively. Tyk2-IN-7 provides a highly selective alternative to conventional TYK2 orthosteric inhibitors, inhibits TYK2/JAK1/JAK2 kinase domain. Tyk2-IN-7 can inhibit the IL-23 and IFN-α signaling pathways. Tyk2-IN-7 is commonly used in the study of inflammatory conditions such as colitis .

HY-50898S

Lapatinib-d4
Lapatinib-d₄ is the deuterium labeled Lapatinib (HY-50898). Lapatinib is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC₅₀ values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively .

HY-W719359

PHT-427-d4
PHT-427-d₄ is the deuterium labeled PHT-427 (HY-12063). PHT-247 is an inhibitor of the pleckstrin homology (PH) domain of Akt, and it is also an inhibitor of PDPK1 with Kis of 2.7 μM and 5.2 μM and for Akt and PDPK1, respectively.

HY-50898S2

Lapatinib-d5
Lapatinib-d₅ is deuterium labeled Lapatinib. Lapatinib (GW572016) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC₅₀ values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively .

HY-149892S

TYK2 JH2-IN-1-d3
TYK2?JH2-IN-1-d₃ is the a deuterated, orally active and selective TYK2 inhibitor (compound 4h), targeting to JH2 domain (IC₅₀=0.1 nM) .

HY-50898S1

Lapatinib-d7 dihydrochloride
Lapatinib-d₇ dihydrochloride is the deuterium labeled Lapatinib dihydrochloride. Lapatinib (GW572016) dihydrochloride is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC₅₀ values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively .

HY-50898S3

Lapatinib-d4-1
Lapatinib-d₄-1 is deuterium labeled Lapatinib. Lapatinib (GW572016) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC₅₀ values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively .

HY-139289S

ART899
ART899 is a highly specific allosteric inhibitor of the Polθ DNA polymerase domain. ART899 can effectively enhance the radiosensitivity of tumor cells, shows good tolerance when combined with fractionated radiation, and significantly reduces tumor growth compared to radiation alone .

HY-163312S

Tyk2-IN-18-d5
Tyk2-IN-18-d5 (Compound 13) is the deuterated TYK2 inhibitor, targeting to JH2 domain. Tyk2-IN-18-d5 can be used for the research of inflammatory and autoimmune diseases .

HY-50898S4

Lapatinib-d7
Lapatinib-d₇ (GW572016-d₇) is deuterium labeled Lapatinib. Lapatinib (GW572016) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC₅₀ values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively .

HY-50898CS

Lapatinib-d4 tosylate
Lapatinib-d₄ (GW572016-d₄) tosylate is deuterium labeled Lapatinib (tosylate). Lapatinib (GW572016) tosylate is a potent, orally active inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC₅₀ values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively .

HY-13956S1

Pioglitazone-d4 (alkyl)
Pioglitazone-d₄ (alkyl) (U 72107-d₄ (alkyl)) is the deuterium labeled Pioglitazone. Pioglitazone (U 72107) is a potent and selective PPARγ agonist with high affinity binding to the PPARγ ligand-binding domain with EC₅₀ of 0.93 and 0.99 μM for human and mouse PPARγ, respectively .

HY-B1322AS

Amodiaquine-d10
Amodiaquine-d₁₀ is the deuterium labeled Amodiaquine. Amodiaquine (Amodiaquin), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor. Amodiaquine is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC₅₀ of ~20 μM. Anti-inflammatory effect .

HY-W777297

Lapatinib-13C2,15N Ditosylate
Lapatinib- ¹³C₂, ¹⁵N Ditosylate is the ¹³C- and ¹⁵N-labeled Lapatinib ditosylate (HY-50898A). Lapatinib ditosylate (GW572016 ditosylate) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC₅₀ values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively .

HY-W013049S

Docosanoic acid-d4
Docosanoic acid-d₄ (Behenic acid-₄) is deuterium labeled Docosanoic acid (HY-W013049). Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a K_d of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans .

HY-W013049S2

Docosanoic acid-d2
Docosanoic acid-d₂ (Behenic acid-d₂) is deuterium labeled Docosanoic acid (HY-W013049). Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a K_d of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans .

HY-W013049S6

Docosanoic acid-13C4
Docosanoic acid- ¹³C₄ (Behenic acid- ¹³C₄) is the ¹³C-labeled Docosanoic acid (HY-W013049). Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a K_d of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in vivo .

HY-W013049S1

Docosanoic acid-d43
Docosanoic acid-d₄₃ (Behenic acid-d₄₃) is the deuterium labeled Docosanoic acid (HY-W013049). Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a K_d of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans .

HY-10528S

Tasquinimod-d3
Tasquinimod-d3 (ABR-215050-d3) is the deuterium labeled Tasquinimod (HY-10528). Tasquinimod is an oral antiangiogenic agent, which plays an important role in castration-resistant prostate cancer. Tasquinimod binds to the regulatory Zn ²⁺ binding domain of HDAC4 with K_d of 10-30 nM. Tasquinimod also is a S100A9 inhibitor .

HY-W013049S3

Docosanoic acid-d3
Docosanoic acid-d₃ (Behenic acid-d₃) is the deuterium labeled Docosanoic acid (HY-W013049). Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a K_d of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans .

HY-W013049S4

Docosanoic acid-d4-1
Docosanoic acid-d₄-1 (Behenic acid-d₄-1) is the deuterium labeled Docosanoic acid (HY-W013049). Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a K_d of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans .

HY-W013049S5

Docosanoic acid-d4-2
Docosanoic acid-d₄-2 (Behenic acid-d₄-2) is the deuterium labeled Docosanoic acid (HY-W013049). Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a K_d of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans .

HY-B1322AS1

Amodiaquine-d10 hydrochloride
Amodiaquine-d₁₀ hydrochloride is deuterated labeled Amodiaquine (HY-B1322A). Amodiaquine (Amodiaquin), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor. Amodiaquine is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC₅₀ of ~20 μM. Anti-inflammatory effect .

HY-B0563S1

Ropivacaine-d7

Ropivacaine-d₇ is deuterium labeled Ropivacaine. Ropivacain is a potent?sodium channel?blocker. Ropivacain blocks impulse conduction via reversible inhibition of?sodium ion influx?in nerve fibrese . Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC₅₀ of 402.7 μM in COS-7 cell's membrane . Ropivacaine is used for the research of neuropathic pain?management .

HY-10235S

Telaprevir-d4
Telaprevir-d₄ is the deuterium labeled Telaprevir. Telaprevir (VX-950) is a highly selective, reversible, and potent peptidomimetic inhibitor of the HCV NS3-4A protease, the steady-state inhibitory constant (Ki) of Telaprevir is 7 nM against a genotype 1 (H strain) NS3 protease domain plus a NS4A cofactor peptide . Telaprevir inhibits SARS-CoV-2 3CLpro activity .

HY-B0563BS

Ropivacaine-d7 hydrochloride

Ropivacaine-d₇ hydrochloride is a deuterium labeled Ropivacaine (hydrochloride) (HY-B0563B) . Ropivacaine hydrochloride is a potent sodium channel blocker and blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese . Ropivacaine is also an inhibitor of K_2P (two-pore domain potassium channel) TREK-1 with an IC₅₀ of 402.7 μM in COS-7 cell's membrane . Ropivacaine is widely used for neuropathic pain management in vivo .

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