CDCP1 Protein, Cynomolgus (HEK293, C-His)

CDCP1 Protein, Cynomolgus (HEK293, C-His) is the recombinant cynomolgus-derived CDCP1 protein, expressed by HEK293, with C-His tag.

CDCP1, a cell surface glycoprotein, is a ligand for CD6, a receptor molecule expressed on certain T cells that may play a role in T cell migration and chemotaxis. CDCP1 may lead to autoimmune diseases such as encephalomyelitis, multiple sclerosis and inflammatory arthritis. CDCP1 mediates anti-adhesion and anti-migration by negatively regulating integrin receptors. CDCP1 promotes tumor proliferation and metastasis by activating MAPK/ERK and AKT signaling pathways^[1][2][3].

Immobilized Cynomolgus CDCP1, His Tag at 1 μg/mL (100 μl/well) on the plate. Dose response curve for Anti-CDCP1 Antibody, hFc Tag with the EC₅₀ of <30 ng/mL determined by ELISA.

Cynomolgus

HEK293

C-8*His

XP_005546930 (F30-T667)

102129146

Extracellular Domain

FEIALPRESNITVLIKLGTPTLLAKPCYIVISKRHTTMLSIKPGERILFTFSCQSPENHFVIEIQKNIDCMSGPCPFGEVQLQPSTSLLPTLNRTFIWDVKAHKSIGLELQFSIPRLRQIGPGESCPDGVTYSISGRIDATVVRIGTFCSNGTVSRIKMQEGVKMALHLPWFHPRNVSGFSIANRSSIKRLCIIESVFEGEGSATLMSANYPEGFPEDELMTWQFVIPAHLRASVSFLNFNLSNCERKEERVEYYIPGSTTNPEVFKLEDKQPGNMAGNFNLSLQGCDQDAQNPGILRLQFQVLVQHPQNESNKIYVVDLSNERATSLTIEPRPVKQSRKFVPGCFVCLESRTCSTNLTLTSGSKHKISFLCDNLTRLWMNVEKNISCTDHRYCQRKSYSLQVPSDILHLPVELHDFSWKLLVPKDRLSLVLVPAQKLQQHTHEKPCNTSFSYLVASAIPSQDLYFGSFCPGGSIEQIQVKQNISVTLRTFAPSFRQEASRQGLTVSFIPYFKEEGVFTVTPDTKSKVYLRTPNWDRGLPSLTSVSWNISVPRDQVACLTFFKERTGVVCQTGRAFMIIQEQRTRAEEIFSLDEDALPKPRFHHHSFWVNISNCSPASGKQLDLLFWVTLTPRTVDLT

Approximately 90-110 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 8% trehalose.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.