KDM6B Protein, Human (sf9, His)

KDM6B protein is a histone demethylase targeting "Lys-27" of histone H3, which mainly affects the histone code. Demethylates H3 "Lys-27" to shape the epigenetic landscape. KDM6B Protein, Human (sf9, His) is the recombinant human-derived KDM6B protein, expressed by sf9 insect cells , with N-8*His labeled tag.

KDM6B Protein, a histone demethylase with specificity for 'Lys-27' of histone H3, holds a central position in the intricate histone code, as evidenced by multiple studies. This enzyme demethylates both trimethylated and dimethylated H3 'Lys-27,' playing a pivotal role in shaping the epigenetic landscape. Beyond its role in histone modification, KDM6B emerges as a key regulator of posterior development, exerting influence on HOX gene expression and contributing to developmental processes. In the context of inflammatory responses, KDM6B plays a vital role in macrophage differentiation during inflammation, impacting gene expression and the differentiation process. Additionally, KDM6B exhibits a demethylase-independent function in chromatin remodeling, serving as a critical link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex, thereby regulating T-box family member-dependent gene expression (By similarity). The multifaceted roles of KDM6B underscore its significance in the dynamic regulation of chromatin structure and gene expression.

Human

Sf9 insect cells

N-8*His

O15054 (D1141-L1636)

/

Partial

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.