USP3 ZnF-UBD ligand-1

Cat. No.: HY-157428: Data Sheet
SDS
Handling Instructions
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USP3 ZnF-UBD ligand-1 (compound 59) is a ligand that binds to the zinc finger ubiquitin-binding domain (ZnF-UBD) of USP3 with a K_D of 14 μM.

For research use only. We do not sell to patients.

USP3 ZnF-UBD ligand-1 Chemical Structure

CAS No. : 2419322-41-9

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Purity & Documentation
References
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Description

USP3 ZnF-UBD ligand-1 (compound 59) is a ligand that binds to the zinc finger ubiquitin-binding domain (ZnF-UBD) of USP3 with a K_D of 14 μM^[1].

Molecular Weight

373.38

Formula

C₁₇H₁₅N₃O₅S

CAS No.

2419322-41-9

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=S(NC1=CC=CC(C(CCC(O)=O)=O)=C1)(C2=CNC3=NC=CC=C32)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (267.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6782 mL	13.3912 mL	26.7824 mL
5 mM	0.5356 mL	2.6782 mL	5.3565 mL
10 mM	0.2678 mL	1.3391 mL	2.6782 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Data Sheet (272 KB) SDS (252 KB) Handling Instructions (2659 KB)

References

[1]. Mann M K, Wolf E, Silva M, et al. Small molecule screen identifies non-catalytic USP3 chemical handle[J]. ACS Omega, 2023.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6782 mL	13.3912 mL	26.7824 mL	66.9559 mL
	5 mM	0.5356 mL	2.6782 mL	5.3565 mL	13.3912 mL
	10 mM	0.2678 mL	1.3391 mL	2.6782 mL	6.6956 mL
	15 mM	0.1785 mL	0.8927 mL	1.7855 mL	4.4637 mL
	20 mM	0.1339 mL	0.6696 mL	1.3391 mL	3.3478 mL
	25 mM	0.1071 mL	0.5356 mL	1.0713 mL	2.6782 mL
	30 mM	0.0893 mL	0.4464 mL	0.8927 mL	2.2319 mL
	40 mM	0.0670 mL	0.3348 mL	0.6696 mL	1.6739 mL
	50 mM	0.0536 mL	0.2678 mL	0.5356 mL	1.3391 mL
	60 mM	0.0446 mL	0.2232 mL	0.4464 mL	1.1159 mL
	80 mM	0.0335 mL	0.1674 mL	0.3348 mL	0.8369 mL
	100 mM	0.0268 mL	0.1339 mL	0.2678 mL	0.6696 mL