2. Protein Tyrosine Kinase/RTK Others Metabolic Enzyme/Protease Stem Cell/Wnt JAK/STAT Signaling Apoptosis
  3. SHP1 Fluorescent Dye Phosphatase STAT Apoptosis
  4. SHP1 activator 1

SHP1 activator 1 (Compound 3n) is an activator for src homology-2 domain-containing protein tyrosine phosphatase 1(SHP1) with an EC50 of 17.66 μM. SHP1 activator 1 inhibits the proliferation of ABC-DLBCL cells, induces apoptosis by inhibiting STAT3 signaling pathway. SHP1 activator 1 emitts blue and green fluorescence signalis in MDA-MB-231 cell, and can be used as a cell imaging agent.

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SHP1 activator 1 Chemical Structure

SHP1 activator 1 Chemical Structure

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Description

SHP1 activator 1 (Compound 3n) is an activator for src homology-2 domain-containing protein tyrosine phosphatase 1(SHP1) with an EC50 of 17.66 μM. SHP1 activator 1 inhibits the proliferation of ABC-DLBCL cells, induces apoptosis by inhibiting STAT3 signaling pathway. SHP1 activator 1 emitts blue and green fluorescence signalis in MDA-MB-231 cell, and can be used as a cell imaging agent[1].

Molecular Weight

478.58

Formula

C27H34N4O4
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1OC2=CC(N(CC)CC)=CC=C2C=C1C(NC3=CC=C(C(NCCN(CC)CC)=O)C=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature, keep dry and cool

In solvent -80°C 2 years
-20°C 1 year
Purity & Documentation
References
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SHP1 activator 1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SHP1 activator 1SHP1Fluorescent DyePhosphataseSTATApoptosisShp1PTPN6Src homology region 2 (SH-2) domain-containing phosphatase 1ABC-DLBCLMDA-MB-231OCI-Ly10SU-DHL-2cell imagingInhibitorinhibitorinhibit

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