2. Protein Tyrosine Kinase/RTK Others Metabolic Enzyme/Protease Stem Cell/Wnt JAK/STAT Signaling Apoptosis
  3. SHP1 Fluorescent Dye Phosphatase STAT Apoptosis
  4. SHP1 activator 1

SHP1 activator 1 (Compound 3n) is an activator for src homology-2 domain-containing protein tyrosine phosphatase 1(SHP1) with an EC50 of 17.66 μM. SHP1 activator 1 inhibits the proliferation of ABC-DLBCL cells, induces apoptosis by inhibiting STAT3 signaling pathway. SHP1 activator 1 emitts blue and green fluorescence signalis in MDA-MB-231 cell, and can be used as a cell imaging agent.

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SHP1 activator 1 Chemical Structure

SHP1 activator 1 Chemical Structure

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Description

SHP1 activator 1 (Compound 3n) is an activator for src homology-2 domain-containing protein tyrosine phosphatase 1(SHP1) with an EC50 of 17.66 μM. SHP1 activator 1 inhibits the proliferation of ABC-DLBCL cells, induces apoptosis by inhibiting STAT3 signaling pathway. SHP1 activator 1 emitts blue and green fluorescence signalis in MDA-MB-231 cell, and can be used as a cell imaging agent[1].

Molecular Weight

478.58

Formula

C27H34N4O4
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1OC2=CC(N(CC)CC)=CC=C2C=C1C(NC3=CC=C(C(NCCN(CC)CC)=O)C=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature, keep dry and cool

In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (52.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0895 mL 10.4476 mL 20.8951 mL
5 mM 0.4179 mL 2.0895 mL 4.1790 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0895 mL 10.4476 mL 20.8951 mL 52.2379 mL
5 mM 0.4179 mL 2.0895 mL 4.1790 mL 10.4476 mL
10 mM 0.2090 mL 1.0448 mL 2.0895 mL 5.2238 mL
15 mM 0.1393 mL 0.6965 mL 1.3930 mL 3.4825 mL
20 mM 0.1045 mL 0.5224 mL 1.0448 mL 2.6119 mL
25 mM 0.0836 mL 0.4179 mL 0.8358 mL 2.0895 mL
30 mM 0.0697 mL 0.3483 mL 0.6965 mL 1.7413 mL
40 mM 0.0522 mL 0.2612 mL 0.5224 mL 1.3059 mL
50 mM 0.0418 mL 0.2090 mL 0.4179 mL 1.0448 mL
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SHP1 activator 1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SHP1 activator 1SHP1Fluorescent DyePhosphataseSTATApoptosisShp1PTPN6Src homology region 2 (SH-2) domain-containing phosphatase 1ABC-DLBCLMDA-MB-231OCI-Ly10SU-DHL-2cell imagingInhibitorinhibitorinhibit

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