2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies
  5. BLNK Antibody (YA2282)

BLNK Antibody (YA2282)

Cat. No.: HY-P82537
User Guide for Antibodies Technical Support

BLNK Antibody (YA2282) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BLNK.

For research use only. We do not sell to patients.

Size Price Stock Quantity
10 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
50 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
100 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
250 μL   Get quote  
Synthetic products have potential research and development risk.
or Bulk Inquiry

* Please select Quantity before adding items.

Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

BLNK Antibody (YA2282) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BLNK.
Background

BLNK, a central linker protein, operates downstream of the B-cell receptor (BCR), serving as a crucial bridge that connects the SYK kinase to various signaling pathways and regulates diverse biological outcomes in B-cell function and development. Its functional spectrum includes playing a role in the activation of ERK/EPHB2, MAP kinase p38, and JNK, as well as modulating AP1 activation. BLNK is pivotal for the activation of NF-kappa-B and NFAT, contributing significantly to BCR-mediated PLCG1 and PLCG2 activation, Ca(2+) mobilization, and the trafficking of the BCR to late endosomes. Notably, BLNK is dispensable for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. Additionally, it may be crucial for the RAC1-JNK pathway and plays a critical role in orchestrating the pro-B cell to pre-B cell transition. BLNK's involvement extends to potential participation in BCR-induced B-cell apoptosis, forming essential associations with PLCG1, VAV1, NCK1, VAV3, PLCG2, GRB2, CD79A, and phosphorylated and activated SYK, thereby intricately connecting with key elements in B-cell signaling pathways.
Gene ID
SwissProt ID
Synonyms
BLNK; BASH; SLP65; B-cell linker protein; B-cell adapter containing a SH2 domain protein; B-cell adapter containing a Src homology 2 domain protein; Cytoplasmic adapter protein; Src homology 2 domain-containing leukocyte protein of 65 kDa
Molecular Weight

Predicted band size: 50 kDa; Observed band size: 70 kDa
Purity

Affinity Purified
Conjugation

Non-conjugated
Modification

Unmodified
Research Field

Immunology
Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality

Recombinant, Monoclonal
Host

Rabbit
Reactivity

Human, Mouse, Rat
Dilution Ratio

WB: 1:500-1:1000; IP: 1:20
Application

WB, IP
Appearance

Liquid
Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

A synthetic peptide of human BLNK
Database

Entrez Gene: 29760 Human ; 17060 Mouse ; 499356 Rat

SwissProt: Q8WV28 Human ; Q9QUN3 Mouse ; Q4KM52 Rat

OMIM: 613502 Human

Documentation
User Guide for Antibodies (1077 KB)

BLNK Antibody (YA2282) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
BLNK Antibody (YA2282)
Cat. No.:
HY-P82537
Quantity:
MCE Japan Authorized Agent:

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Country or Region *

Email Address *

     

Phone Number *

 

Organization Name *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.