2. Recombinant Proteins
  3. Receptor Proteins
  4. Pattern Recognition Receptors
  5. C-type Lectin Receptors
  6. MDL-1/CLEC5A
  7. CLEC5A/MDL-1 Protein, Rhesus Macaque (HEK293, Fc)

CLEC5A/MDL-1 Protein, Rhesus Macaque (HEK293, Fc)

Cat. No.: HY-P77338
Handling Instructions Technical Support

CLEC5A Protein is a cell surface receptor that signals via TYROBP, and functions as a positive regulator of osteoclastogenesis. CLEC5A Protein regulates inflammatory responses. CLEC5A/MDL-1 Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived CLEC5A/MDL-1 protein, expressed by HEK293 , with N-mFc labeled tag.

For research use only. We do not sell to patients.

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Description

CLEC5A Protein is a cell surface receptor that signals via TYROBP, and functions as a positive regulator of osteoclastogenesis. CLEC5A Protein regulates inflammatory responses. CLEC5A/MDL-1 Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived CLEC5A/MDL-1 protein, expressed by HEK293 , with N-mFc labeled tag.
Background

CLEC5A Protein is a critical macrophage receptor for dengue virus serotypes 1-4. The binding of CLEC5A Protein to dengue virus triggers signaling through the phosphorylation of TYROBP, and not results in viral entry, but stimulates pro-inflammatory cytokine release[1][2][3].
Species

Rhesus Macaque
Source

HEK293
Tag

N-mFc
Accession

XP_001085243 (P28-K188)
Gene ID
Molecular Construction
N-term
mFc
CLEC5A (P28-K188)
Accession # XP_001085243
C-term
Synonyms
C-type lectin domain family 5 member A; MDL-1; CLECSF5
Molecular Weight

Approximately 45.3 kDa.
Purity

Greater than 90% as determined by reducing SDS-PAGE
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

CLEC5A/MDL-1 Protein, Rhesus Macaque (HEK293, Fc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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