2. Anti-infection Metabolic Enzyme/Protease
  3. HIV HIV Integrase
  4. Hyrtiosal

Hyrtiosal, found in the marine sponge Hyrtios erectus, is an inhibitor of the N-terminal domain (NTD) of HIV-1 integrase (HIV-1 IN) with an IC50 value of 9.60-0.86 μM. Hyrtiosal binds to the Ser17, Trp19, and Lys34 sites on the NTD of HIV-1 IN, inhibiting the binding of HIV-1 viral DNA to integrase and interfering with the formation of the pre-integrated complex of HIV-1. Hyrtiosal is promising for research of anti-HIV agents.

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Hyrtiosal Chemical Structure

Hyrtiosal Chemical Structure

CAS No. : 138355-07-4

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Hyrtiosal Related Antibodies

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Description

Hyrtiosal, found in the marine sponge Hyrtios erectus, is an inhibitor of the N-terminal domain (NTD) of HIV-1 integrase (HIV-1 IN) with an IC50 value of 9.60-0.86 μM. Hyrtiosal binds to the Ser17, Trp19, and Lys34 sites on the NTD of HIV-1 IN, inhibiting the binding of HIV-1 viral DNA to integrase and interfering with the formation of the pre-integrated complex of HIV-1. Hyrtiosal is promising for research of anti-HIV agents[1].

Molecular Weight

386.57

Formula

C25H38O3
CAS No.
SMILES

C[C@]12[C@@](C[C@@](C)([C@H]2C[C@@H](C3=COC=C3)O)C=O)([H])[C@@]4([C@@](C(C)(CCC4)C)([H])CC1)C
Structure Classification
Initial Source

marine sponge Hyrtios erectus
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Hyrtiosal Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hyrtiosal138355-07-4HIVHIV IntegraseHuman immunodeficiency virusHIV-1 integraseHIV-1Inhibitorinhibitorinhibit

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