2. Neuronal Signaling
  3. Tau Protein
  4. CHIPOpt

CHIPOpt, a peptide, is an orthosteric CHIP TPR domain inhibitor with a Kd of ∼16 nM. CHIPOpt has anti-aggregation activity and decreases p.tau ubiquitination with little effect on unmodified tau. CHIPOpt can be used for Alzheimer’s disease research.

For research use only. We do not sell to patients.

CHIPOpt

CHIPOpt Chemical Structure

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CHIPOpt Related Antibodies

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Description

CHIPOpt, a peptide, is an orthosteric CHIP TPR domain inhibitor with a Kd of ∼16 nM. CHIPOpt has anti-aggregation activity and decreases p.tau ubiquitination with little effect on unmodified tau. CHIPOpt can be used for Alzheimer’s disease research[1].

Molecular Weight

757.83

Formula

C39H47N7O9
Sequence

Ac-Leu-Trp-Trp-Pro-Asp
Sequence Shortening

Ac-LWWPD
SMILES

O=C(C)N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(O)=O)CC(O)=O)=O)CCC1)=O)CC2=CNC3=CC=CC=C23)=O)CC4=CNC5=CC=CC=C45)=O)CC(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CHIPOpt Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CHIPOptTau ProteinInhibitorCHIP TPR domainAnti-aggregationp.tauUbiquitinationAlzheimer’s diseaseinhibitorinhibit

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