2. Protein Tyrosine Kinase/RTK
  3. c-Kit
  4. Anti-c-Kit/CD117 Antibody (SR-1)

Anti-c-Kit/CD117 Antibody (SR-1) is a kind of mouse IgG2a κ chimeric antibody inhibitor, targeting to human c-Kit/CD117. Anti-c-Kit/CD117 Antibody (SR-1) binds to the extracellular domain of human c-Kit (also known as CD117) and blocks stem cell factor (SCF) binding to CD117. Anti-c-Kit/CD117 Antibody (SR-1) can be used for the researches of cancer and immunology, such as gastrointestinal stromal tumor (GIST) and xenograft.

For research use only. We do not sell to patients.

Anti-c-Kit/CD117 Antibody (SR-1)

Anti-c-Kit/CD117 Antibody (SR-1) Chemical Structure

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Anti-c-Kit/CD117 Antibody (SR-1) Related Antibodies

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Description

Anti-c-Kit/CD117 Antibody (SR-1) is a kind of mouse IgG2a κ chimeric antibody inhibitor, targeting to human c-Kit/CD117. Anti-c-Kit/CD117 Antibody (SR-1) binds to the extracellular domain of human c-Kit (also known as CD117) and blocks stem cell factor (SCF) binding to CD117. Anti-c-Kit/CD117 Antibody (SR-1) can be used for the researches of cancer and immunology, such as gastrointestinal stromal tumor (GIST) and xenograft[1][2].

Isotype

Mouse IgG2a kappa
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target

c-Kit/CD117
In Vitro

Anti-c-Kit/CD117 Antibody (SR-1) (10 μg/mL, 12 h) inhibits cell growth and reduces cell-surface KIT expression in GIST48/GIST430/GIST882 cells[1].
Anti-c-Kit/CD117 Antibody (SR-1) (10 μg/mL, 2 h) allows for phagocytosis of gastrointestinal stromal tumor (GIST) cells by macrophages in GIST48/GIST430/GIST882 and LMS05 cells co-cultures[1].
Anti-c-Kit/CD117 Antibody (SR-1) (0.01-100 μg/mL, 2 weeks) inhibits cells proliferation in human hematopoietic stem cells (HSC)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-c-Kit/CD117 Antibody (SR-1) Related Antibodies
In Vivo

Anti-c-Kit/CD117 Antibody (SR-1) (500 μg, i.p., weekly 2 weeks after cells engraftment) inhibits tumor growth in GIST430/GIST882 xenograft tumor NSG mice[1].
Anti-c-Kit/CD117 Antibody (SR-1) (500 μg, i.v., at days 1, 3, 5, and 7) depletes normal and myelodysplastic syndrome human hematopoietic stem cells (HSC) in HSC xenografted NSG mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: GIST430 xenograft tumor mice models of imatinib (HY-15463)-resistant and GIST882 xenograft tumor mice models of imatinib-sensitive (4-8 weeks, NSG mice)[1]
Dosage: 500 μg
Administration: Intraperitoneally injection, weekly 2 weeks after cells engraftment
Result: Inhibited tumor growth.
Animal Model: Human hematopoietic stem cells (HSC)-xenografted NSG mice (prenatal day 0 (P0) to P3 newborn pups) [2]
Dosage: 500 μg
Administration: Intravenously injection, at days 1, 3, 5, and 7
Result: Depleted human CD451CD13/331 cells.
Depleted cells from high and low-risk MDS subtypes.
Generated human myeloid and lymphoid cells in the BM.
Allowed subsequent engraftment of healthy human HSCs and restored of normal human hematopoiesis.
Gene ID

16590  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

SMILES

[Anti-c-Kit/CD117 Antibody (SR-1)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-c-Kit/CD117 Antibody (SR-1) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-c-Kit/CD117 Antibody (SR-1)c-KitSCFRCD117C-KitSCFGISTXenograftHSCGIST48GIST430GIST882Inhibitorinhibitorinhibit

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