DDIT3 Antibody

Cat. No.: HY-P81233: Data Sheet COA
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DDIT3 Antibody is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DDIT3.

For research use only. We do not sell to patients.

Size	Stock	Quantity
10 μL	In-stock	Estimated Time of Arrival: December 31
50 μL	In-stock	Estimated Time of Arrival: December 31
100 μL	In-stock	Estimated Time of Arrival: December 31
250 μL	Get quote

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DDIT3 Antibody Featured Recommendations:

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

Biological Activity
Technical Parameters
Properties
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Description	DDIT3 Antibody is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DDIT3.
Background	CHOP is a multifunctional transcription factor primarily involved in the endoplasmic reticulum (ER) stress response. It plays a crucial role in various cellular stress responses and induces cell cycle arrest and apoptosis under ER stress conditions. CHOP exhibits dual functionality as both an inhibitor of CCAAT/enhancer-binding protein (C/EBP) and an activator of other genes (By similarity). It acts as a dominant-negative regulator of C/EBP by dimerizing with its family members, impairing their binding to promoter regions and suppressing C/EBP-regulated gene expression (By similarity). CHOP positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM, and ERO1L, while negatively regulating BCL2, MYOD1, ASNS, HAMP, and PPARG expression. In collaboration with ATF4, CHOP mediates ER stress-induced cell death by promoting genes related to amino acid metabolism, mRNA translation, and the unfolded protein response (UPR) (By similarity). Additionally, CHOP inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4 and participates in inflammatory response regulation by inducing caspase-11 (CASP4/CASP11) and caspase-1 (CASP1) activation, which process pro-IL1B into mature IL1B (By similarity). It also serves as a key regulator of postnatal neovascularization through endothelial nitric oxide synthase (NOS3)-related signaling (By similarity).
Gene ID	1649 [NCBI]
SwissProt ID	P35638
Synonyms	GADD153; CHOP; Growth arrest and DNA damage-inducible 153; C/EBP homologous protein; C/EBP Homology Protein; CEBPZ; CHOP10; DDIT 3; DNA Damage Inducible Transcript 3; GADD 153; Growth Arrest and DNA Damage Inducible Protein 153; Growth arrest and DNA damage inducible protein GADD153; MGC4154; DDIT3_HUMAN.
Molecular Weight	Predicted band size: 19kDa;Observed band size: 27kDa
Purity	affinity purified
Subcellular Location	Cytoplasm. Nucleus. Note=Present in the cytoplasm under non-stressed conditions and ER stress leads to its nuclear accumulation.
Conjugation	Non-conjugated
Modification	Unmodified
RRID	AB_3103287
Product Categories	Primary Antibody; Mouse monoclonal Antibody
Clonality	Monoclonal
Host	Mouse
Reactivity	Human, Mouse, Rat
Dilution Ratio	WB: 1:500-1:1000; IHC: 1:50-1:100; IF: 1:50-1:200
Application	WB, IHC-P, ICC/IF
Appearance	Liquid
Formulation	Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Storage & Stability	Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping	Shipping with blue ice.
Isotype	IgG1
Sensitivity	Endogenous
Immunogen	Synthetic peptide conjugated to KLH.
Database	Entrez Gene: 1649 Human ; 13198 Mouse ; 29467 Rat SwissProt: P35638 Human ; P35639 Mouse ; Q62857 Rat OMIM: 613488 Human
Documentation	Select Batch: Data Sheet (235 KB) SDS (251 KB) COA (205 KB) User Guide for Antibodies (1077 KB)

DDIT3 Antibody Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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DDIT3 Antibody

DDIT3 Antibody Featured Recommendations:

Biological Activity

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DDIT3 Antibody Related Classifications

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