Protein Kinase C (19-35) Peptide

Name: Protein Kinase C (19-35) Peptide
Brand: MedChemExpress
SKU: HY-P3892
Rating: 4.5 (1 reviews)

Cat. No.: HY-P3892 Purity: 99.90%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

Protein Kinase C (19-35) Peptide is the PKC pseudosubstrate inhibitor/region. Protein Kinase C (19-35) Peptide possibly blocks the substrate-binding site in its kinase domain, makes the cytoplasmic form of PKC inactive.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Protein Kinase C (19-35) Peptide Chemical Structure

CAS No. : 309247-48-1

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKC-ι ℩ PKCι

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Amino acids equivalent to residues 19-36 and 19-29 of PKC-β can bound to phospholipid vesicles^[2].
Atypical zeta protein kinase C in the signaling pathway leading to chemoattractant-triggered actin assembly, integrin-dependent adhesion of blood leukocytes to vascular endothelium^[3].
Synthetic myristoylated peptides with Protein Kinase C (19-35) Peptide, the endogenous zeta protein kinase C pseudosubstrate region, block agonist-induced adhesion to fibrinogen, chemotaxis and F-actin accumulation^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

2037.40

Formula

C₈₉H₁₅₃N₃₃O₂₂

CAS No.

309247-48-1

Appearance

Solid

Color

White to off-white

Sequence Shortening

RFARKGALRQKNVHEVK

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : ≥ 100 mg/mL (49.08 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.4908 mL	2.4541 mL	4.9082 mL
5 mM	0.0982 mL	0.4908 mL	0.9816 mL
10 mM	0.0491 mL	0.2454 mL	0.4908 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.90%

Select Batch:

Data Sheet (270 KB) SDS (252 KB)

COA (243 KB) RP-HPLC (254 KB) MS (70 KB)

Handling Instructions (2659 KB)

References

[1]. Steiner J, et al. The effect of acute ethanol (EtOH) exposure on protein kinase C (PKC) activity in anterior pituitary. Alcohol. 1997 May-Jun;14(3):209-11. [Content Brief]

[2]. Mosior M, et al. Peptides that mimic the pseudosubstrate region of protein kinase C bind to acidic lipids in membranes. Biophys J. 1991 Jul;60(1):149-59. [Content Brief]

[3]. Laudanna C, et al. Evidence of zeta protein kinase C involvement in polymorphonuclear neutrophil integrin-dependent adhesion and chemotaxis. J Biol Chem. 1998 Nov 13;273(46):30306-15. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	0.4908 mL	2.4541 mL	4.9082 mL	12.2705 mL
	5 mM	0.0982 mL	0.4908 mL	0.9816 mL	2.4541 mL
	10 mM	0.0491 mL	0.2454 mL	0.4908 mL	1.2271 mL
	15 mM	0.0327 mL	0.1636 mL	0.3272 mL	0.8180 mL
	20 mM	0.0245 mL	0.1227 mL	0.2454 mL	0.6135 mL
	25 mM	0.0196 mL	0.0982 mL	0.1963 mL	0.4908 mL
	30 mM	0.0164 mL	0.0818 mL	0.1636 mL	0.4090 mL
	40 mM	0.0123 mL	0.0614 mL	0.1227 mL	0.3068 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.