THAP11 Antibody (YA5079)

THAP11 Antibody (YA5079) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to THAP11.

THAP11 is a transcription factor with dual transcriptional activation and repression activities (PubMed:31905202) that also modulates chromatin accessibility (PubMed:38361031). In complex with HCFC1 and ZNF143, it regulates genes including AP2S1, ESCO2, OPHN1, RBL1, UBXN8, and ZNF32 (PubMed:26416877). By similarity, THAP11 may control expression of cytoplasmic and mitochondrial ribosomal protein genes, is essential for normal mitochondrial development/function, and regulates electron transport chain components. It maintains pluripotency in early embryonic cells (by promoting mitochondrial maturation to meet energy demands) and prevents premature cell cycle exit of retinal progenitor cells during retina development (potentially via mitochondrial effects). THAP11 governs cobalamin metabolism by regulating MMACHC expression (PubMed:28449119, PubMed:31905202), is required for brain development and neural precursor differentiation (by similarity), and modulates cell growth (PubMed:31905202).

Q96EK4

Predicted band size: 34 kDa;

affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

WB: 1:500-1:2000; IHC: 1:200-1:1000; ICC/IF: 1:200-1:1000; FC: 1:200-1:400; ELISA: 1:10000

WB, IHC-P, ICC/IF, FC, ELISA

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant fragment of human THAP11 expressed in E. Coli.