GRB2 Antibody (YA5228)

GRB2 Antibody (YA5228) is a mouse-derived and non-conjugated monoclonal antibody, targeting to GRB2. It can be applicated for WB assays, in the background of human, mouse, rat.

Grb2, an adapter protein, plays a pivotal role in establishing a crucial connection between cell surface growth factor receptors and the Ras signaling pathway. Despite its lack of direct binding to phosphorylated epidermal growth factor receptor (EGFR), Grb2 exerts an inhibitory effect on EGF-induced transactivation of a RAS-responsive element. Notably, Grb2 functions as a dominant negative protein relative to GRB2, suppressing proliferative signals and potentially instigating active programmed cell death.

P62993

Observed band size: 25 kDa

affinity chromatography.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human, Mouse, Rat

WB: 1:1000

WB

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Recombinant protein of human GRB2.