2. PROTAC Autophagy
  3. AUTOTACs p62
  4. YT-8-8

YT-8-8 is a ligand of p62-ZZ domain. YT-8-8 can activate p62-dependent selective macroautophagy. YT-8-8 can be used for AUTOTAC design.

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YT-8-8 Chemical Structure

YT-8-8 Chemical Structure

CAS No. : 892572-23-5

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YT-8-8 Related Antibodies

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Description

YT-8-8 is a ligand of p62-ZZ domain. YT-8-8 can activate p62-dependent selective macroautophagy. YT-8-8 can be used for AUTOTAC design[1].

Molecular Weight

318.39

Formula

C18H23FN2O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OCCNCCNCC1=CC(OCC2=CC=C(F)C=C2)=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 116.67 mg/mL (366.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1408 mL 15.7040 mL 31.4080 mL
5 mM 0.6282 mL 3.1408 mL 6.2816 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1408 mL 15.7040 mL 31.4080 mL 78.5201 mL
5 mM 0.6282 mL 3.1408 mL 6.2816 mL 15.7040 mL
10 mM 0.3141 mL 1.5704 mL 3.1408 mL 7.8520 mL
15 mM 0.2094 mL 1.0469 mL 2.0939 mL 5.2347 mL
20 mM 0.1570 mL 0.7852 mL 1.5704 mL 3.9260 mL
25 mM 0.1256 mL 0.6282 mL 1.2563 mL 3.1408 mL
30 mM 0.1047 mL 0.5235 mL 1.0469 mL 2.6173 mL
40 mM 0.0785 mL 0.3926 mL 0.7852 mL 1.9630 mL
50 mM 0.0628 mL 0.3141 mL 0.6282 mL 1.5704 mL
60 mM 0.0523 mL 0.2617 mL 0.5235 mL 1.3087 mL
80 mM 0.0393 mL 0.1963 mL 0.3926 mL 0.9815 mL
100 mM 0.0314 mL 0.1570 mL 0.3141 mL 0.7852 mL
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YT-8-8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YT-8-8892572-23-5AUTOTACsp62AUTOphagy-TArgeting ChimerasSequestosome-1SQSTM1autophagyAUTOTACInhibitorinhibitorinhibit

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