2. NF-κB
  3. NF-κB IKK
  4. SR12343

SR12343, an IKK/NF-κB inhibitor, is a NF-κB essential modulator (NEMO)-binding domain (NBD) mimetic. SR12343 inhibits TNF-α- and LPS-induced NF-κB activation by blocking the interaction between IKKβ and NEMO, with an IC50 of 37.02 μM for TNF-α-mediated NF-κB activation. SR12343 suppresses LPS-induced acute pulmonary inflammation in mice. SR12343 can be used for research of inflammatory and degenerative diseases.

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SR12343 Chemical Structure

SR12343 Chemical Structure

CAS No. : 2055101-86-3

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
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Based on 1 publication(s) in Google Scholar

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Description

SR12343, an IKK/NF-κB inhibitor, is a NF-κB essential modulator (NEMO)-binding domain (NBD) mimetic. SR12343 inhibits TNF-α- and LPS-induced NF-κB activation by blocking the interaction between IKKβ and NEMO, with an IC50 of 37.02 μM for TNF-α-mediated NF-κB activation. SR12343 suppresses LPS-induced acute pulmonary inflammation in mice. SR12343 can be used for research of inflammatory and degenerative diseases[1].

Molecular Weight

368.66

Formula

C15H15BrClN3O
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(NCCC1=CC=CC(Br)=C1)CNC2=NC=C(Cl)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (271.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7125 mL 13.5626 mL 27.1253 mL
5 mM 0.5425 mL 2.7125 mL 5.4251 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.66%

SDS (251 KB)

COA (243 KB) HNMR (275 KB) LCMS (105 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7125 mL 13.5626 mL 27.1253 mL 67.8132 mL
5 mM 0.5425 mL 2.7125 mL 5.4251 mL 13.5626 mL
10 mM 0.2713 mL 1.3563 mL 2.7125 mL 6.7813 mL
15 mM 0.1808 mL 0.9042 mL 1.8084 mL 4.5209 mL
20 mM 0.1356 mL 0.6781 mL 1.3563 mL 3.3907 mL
25 mM 0.1085 mL 0.5425 mL 1.0850 mL 2.7125 mL
30 mM 0.0904 mL 0.4521 mL 0.9042 mL 2.2604 mL
40 mM 0.0678 mL 0.3391 mL 0.6781 mL 1.6953 mL
50 mM 0.0543 mL 0.2713 mL 0.5425 mL 1.3563 mL
60 mM 0.0452 mL 0.2260 mL 0.4521 mL 1.1302 mL
80 mM 0.0339 mL 0.1695 mL 0.3391 mL 0.8477 mL
100 mM 0.0271 mL 0.1356 mL 0.2713 mL 0.6781 mL
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SR12343 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SR123432055101-86-3SR 12343SR-12343NF-κBIKKNuclear factor-κBNuclear factor-kappaBIκB kinaseI kappa B kinasepulmonary inflammationdegenerative diseaseInhibitorinhibitorinhibit

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