LIM Kinase 1 Antibody (YA1686)

Cat. No.: HY-P81941: Data Sheet User Guide for Antibodies
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LIM Kinase 1 Antibody (YA1686) is a non-conjugated IgG antibody, targeting LIM Kinase 1, with a predicted molecular weight of 73 kDa (observed band size: 73 kDa). LIM Kinase 1 Antibody (YA1686) can be used for WB experiment in human, mouse background.

For research use only. We do not sell to patients.

Size	Stock	Quantity
10 μL	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 μL	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
100 μL	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
250 μL	Get quote

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【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

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Description	LIM Kinase 1 Antibody (YA1686) is a non-conjugated IgG antibody, targeting LIM Kinase 1, with a predicted molecular weight of 73 kDa (observed band size: 73 kDa). LIM Kinase 1 Antibody (YA1686) can be used for WB experiment in human, mouse background.
Background	LIM Kinase 1 (LIMK1) is a serine/threonine-protein kinase that plays a pivotal role in regulating actin filament dynamics. It acts downstream of multiple Rho family GTPase signaling pathways and is activated by upstream kinases such as ROCK1, PAK1, and PAK4, which phosphorylate a threonine residue in its activation loop. Activated LIMK1 phosphorylates and inactivates actin-binding/depolymerizing factors cofilin-1 (CFL1), cofilin-2 (CFL2), and destrin (DSTN), thereby inhibiting the severing of filamentous actin (F-actin) and stabilizing the actin cytoskeleton. Through this mechanism, LIMK1 regulates various actin-dependent biological processes, including cell motility, cell cycle progression, and differentiation. Additionally, LIMK1 phosphorylates TPPP on serine residues, promoting microtubule disassembly, and may contribute to brain development by stimulating axonal outgrowth. By similar: LIMK1 exhibits a dominant-negative effect on actin cytoskeletal changes and is required for atypical chemokine receptor ACKR2-induced phosphorylation of cofilin (CFL1).
Gene ID	3984 [NCBI]
SwissProt ID	P53667
Synonyms	LIMK1; LIMK; LIM domain kinase 1; LIMK-1
Molecular Weight	Predicted band size: 73 kDa; Observed band size: 73 kDa
Purity	Affinity Chromatography
Conjugation	Non-conjugated
Modification	Unmodified
Research Field	Neuroscience
Product Categories	Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality	Recombinant, Monoclonal
Host	Rabbit
Reactivity	Human, Mouse
Dilution Ratio	WB: 1/500-1/1000
Application	WB
Appearance	Liquid
Formulation	Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage & Stability	Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping	Shipping with blue ice.
Isotype	IgG
Sensitivity	Endogenous
Immunogen	A synthesized peptide derived from human LIM Kinase 1
Database	Entrez Gene: 3984 Human ; 16885 Mouse ; SwissProt: P53667 Human ; P53668 Mouse ; P53669 Rat OMIM: 601329 Human
Documentation	Data Sheet (235 KB) User Guide for Antibodies (1077 KB)

LIM Kinase 1 Antibody (YA1686) Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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LIM Kinase 1 Antibody (YA1686)

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