2. Anti-infection
  3. SARS-CoV
  4. Amubarvimab

Amubarvimab  (Synonyms: BRII-196)

Cat. No.: HY-P99435 Purity: 95.00%
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Amubarvimab (BRII-196) is a human IgG1 mAb that bind to non-competing epitopes on the receptor binding domain (RBD) of spike protein, with a KD of 5.88 nM. Amubarvimab can effectively neutralize SARS-CoV-2 variants.

For research use only. We do not sell to patients.

CAS No. : 2509447-07-6

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Based on 1 publication(s) in Google Scholar

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Description

Amubarvimab (BRII-196) is a human IgG1 mAb that bind to non-competing epitopes on the receptor binding domain (RBD) of spike protein, with a KD of 5.88 nM. Amubarvimab can effectively neutralize SARS-CoV-2 variants[1][2].
Isotype

Human IgG1 kappa
Recommend Isotype Controls
In Vitro

Amubarvimab shows specific activity against wild-type SARS-CoV-2 and no cross-reactivity against other coronaviruses[1].
Amubarvimab binds to two regions spanning amino acids 453-505 in the receptor-binding motif (RBM) and amino acids residues 403-421 in the core region of RBD[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Amubarvimab Related Antibodies
In Vivo

Amubarvimab (10-50 mg/kg; i.p.) in combination with romlusevimab significantly decreases viral load in the lungs, and reduces lung pathology in a Syrian golden hamster model of SARS-CoV-2 infection[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

143.84 kDa

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Amubarvimab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Purity & Documentation
References
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Amubarvimab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Amubarvimab2509447-07-6BRII-196BRII196BRII 196SARS-CoVSARS coronavirusIgG1receptor binding domainRBDspike proteinSARS-CoV-2Inhibitorinhibitorinhibit

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