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  5. G3BP Antibody (YA2432)

G3BP Antibody (YA2432) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2432), targeting G3BP, with a predicted molecular weight of 52 kDa (observed band size: 68 kDa). G3BP Antibody (YA2432) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human, mouse, rat background.

For research use only. We do not sell to patients.

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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

G3BP Antibody (YA2432) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2432), targeting G3BP, with a predicted molecular weight of 52 kDa (observed band size: 68 kDa). G3BP Antibody (YA2432) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human, mouse, rat background.
Background

G3BP is a multifunctional protein involved in processes such as stress granule formation and innate immunity. It plays an essential role in stress granule formation, which are membraneless compartments storing mRNAs and proteins during stress responses. G3BP promotes stress granule assembly through liquid-liquid phase separation (LLPS), acting as a molecular switch that triggers RNA-dependent LLPS in response to increased intracellular free RNA concentrations. Additionally, G3BP exhibits ATP- and magnesium-dependent helicase activity, unwinding DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency while moving unidirectionally along single-stranded DNA. In innate immunity, G3BP enhances CGAS and RIGI activity, promoting the DNA-triggered cGAS/STING pathway and RIGI-mediated type I interferon production. In vitro, G3BP may also function as a phosphorylation-dependent sequence-specific endoribonuclease, preferentially cleaving MYC mRNA at the 3'-UTR. by similar: G3BP is implicated in cGAS condensation, likely associated with the formation of membrane-less organelles.
Gene ID
SwissProt ID
Synonyms
G3BP1; G3BP; Ras GTPase-activating protein-binding protein 1; G3BP-1; ATP-dependent DNA helicase VIII; hDH VIII; GAP SH3 domain-binding protein 1
Molecular Weight

Predicted band size: 52 kDa; Observed band size: 68 kDa
Purity

Affinity Purified
Conjugation

Non-conjugated
Modification

Unmodified
RRID
Research Field

Epigenetics and Nuclear Signaling
Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality

Recombinant, Monoclonal
Host

Rabbit
Reactivity

Human, Mouse, Rat
Dilution Ratio

WB: 1/500-1/1000;IHC: 1/50-1/100;IF: 1/50-1/200;IP: 1/20;FC: 1/50-1/100
Application

WB, IHC-P, ICC/IF, IP, FC
Appearance

Liquid
Formulation

Supplied in Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

A synthesized peptide derived from human G3BP
Database

Entrez Gene: 10146 Human ; 27041 Mouse ; 171092 Rat

SwissProt: Q13283 Human ; P97855 Mouse ;

OMIM: 608431 Human

Documentation
SDS (251 KB)

COA (205 KB)

User Guide for Antibodies (1077 KB)

G3BP Antibody (YA2432) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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G3BP Antibody (YA2432)
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HY-P82687
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