2. Metabolic Enzyme/Protease NF-κB
  3. Quinone Reductase Keap1-Nrf2
  4. Nrf2 activator-6

Nrf2 activator-6, a tetrahydroisoquinoline compound, is a Nrf2 activator. Nrf2 activator-6 has an IC50 of 5 nM for inhibiting the Kelch domain-Nrf2 interaction (WO2021214470A1; Example 4).

For research use only. We do not sell to patients.

Nrf2 activator-6 Chemical Structure

Nrf2 activator-6 Chemical Structure

CAS No. : 2728780-74-1

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Nrf2 activator-6 Related Antibodies

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Description

Nrf2 activator-6, a tetrahydroisoquinoline compound, is a Nrf2 activator. Nrf2 activator-6 has an IC50 of 5 nM for inhibiting the Kelch domain-Nrf2 interaction (WO2021214470A1; Example 4)[1].

In Vitro

Nrf2 activator-6 (Example 4) increases the mRNA level of NRF2 mediated gene NADPH:quinone acceptor oxidoreductase 1 (NQO1), with an EC50 of 0.3 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nrf2 activator-6 Related Antibodies
Molecular Weight

614.11

Formula

C31H37ClFN5O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC([C@@](C)(CCC1)[C@@H]1C(N2[C@H](CN3C(CC4(C3)CC4)=O)C5=C(C(F)=CC(Cl)=C5CC2)OCC6=C7N(CCCC7)N=N6)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Nrf2 activator-6 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nrf2 activator-62728780-74-1Quinone ReductaseKeap1-Nrf2Nrf2 activatortetrahydroisoquinolineKelch domain-Nrf2 interactionNQO1Inhibitorinhibitorinhibit

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