2. PROTAC Autophagy
  3. Ligands for Target Protein for PROTAC Autophagy
  4. TSPO ligand-1

TSPO ligand-1 is the ligand of AUTAC4 (HY-134640) that can be used in the synthesis of PROTACs. TSPO ligand-1 is a mitochondrial outer membrane transmembrane structural domain protein can bind to AUTAC4 and regulate mitochondrial autophagy to promote targeted mitochondrial renewal. TSPO ligand-1 is also involved in the transport of cholesterol from the outer to inner mitochondrial membrane and serves as a sensitive biomarker of brain injury and neurodegeneration.

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TSPO ligand-1 Chemical Structure

TSPO ligand-1 Chemical Structure

CAS No. : 4560-08-1

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Based on 1 publication(s) in Google Scholar

TSPO ligand-1 Related Antibodies

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Description

TSPO ligand-1 is the ligand of AUTAC4 (HY-134640) that can be used in the synthesis of PROTACs. TSPO ligand-1 is a mitochondrial outer membrane transmembrane structural domain protein can bind to AUTAC4 and regulate mitochondrial autophagy to promote targeted mitochondrial renewal. TSPO ligand-1 is also involved in the transport of cholesterol from the outer to inner mitochondrial membrane and serves as a sensitive biomarker of brain injury and neurodegeneration[1][2].

In Vitro

TSPO ligand-1 gene is induced to increase expression in the context of selective activation of neurons in male C57Bl6/N mice. Moreover, neuronal activation under physiological and psychopharmacological conditions also results in increased TSPO levels in adult mice[2].
TSPO ligand-1 can serve as the sole marker of glial cell activity in Alzheimer’s disease thus tracking the formation of different neural cells[3].
TSPO ligand-1 can regulate mitochondrial fatty acid oxidation (FAO) and thus effects mitochondrial energy homeostasis in MA-10 Leydig cell line[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TSPO ligand-1 Related Antibodies
Molecular Weight

283.71

Formula

C16H10ClNO2
CAS No.
Appearance

Solid

Color

Light yellow to green yellow

SMILES

O=C(C(C1=C(C2=CC=CC=C2)NC3=C1C=CC=C3)=O)Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (440.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5247 mL 17.6236 mL 35.2473 mL
5 mM 0.7049 mL 3.5247 mL 7.0495 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Purity & Documentation

Purity: ≥98.0%

SDS (251 KB)

COA (257 KB) HNMR (108 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5247 mL 17.6236 mL 35.2473 mL 88.1182 mL
5 mM 0.7049 mL 3.5247 mL 7.0495 mL 17.6236 mL
10 mM 0.3525 mL 1.7624 mL 3.5247 mL 8.8118 mL
15 mM 0.2350 mL 1.1749 mL 2.3498 mL 5.8745 mL
20 mM 0.1762 mL 0.8812 mL 1.7624 mL 4.4059 mL
25 mM 0.1410 mL 0.7049 mL 1.4099 mL 3.5247 mL
30 mM 0.1175 mL 0.5875 mL 1.1749 mL 2.9373 mL
40 mM 0.0881 mL 0.4406 mL 0.8812 mL 2.2030 mL
50 mM 0.0705 mL 0.3525 mL 0.7049 mL 1.7624 mL
60 mM 0.0587 mL 0.2937 mL 0.5875 mL 1.4686 mL
80 mM 0.0441 mL 0.2203 mL 0.4406 mL 1.1015 mL
100 mM 0.0352 mL 0.1762 mL 0.3525 mL 0.8812 mL
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TSPO ligand-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TSPO ligand-14560-08-1TSPO ligand1TSPO ligand 1Ligands for Target Protein for PROTACAutophagyTarget Protein-binding MoietyTSPOAUTAC4 ligandtransporter proteinmitochondriacholesterol transportnerve injuryInhibitorinhibitorinhibit

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