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  5. JAB1 Antibody (YA3159)

JAB1 Antibody (YA3159) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3159), targeting JAB1, with a predicted molecular weight of 38 kDa (observed band size: 38 kDa). JAB1 Antibody (YA3159) can be used for WB, IHC-P, ICC/IF, IP experiment in human, mouse, rat background.

For research use only. We do not sell to patients.

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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

JAB1 Antibody (YA3159) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3159), targeting JAB1, with a predicted molecular weight of 38 kDa (observed band size: 38 kDa). JAB1 Antibody (YA3159) can be used for WB, IHC-P, ICC/IF, IP experiment in human, mouse, rat background.
Background

JAB1 is a probable protease subunit of the COP9 signalosome complex (CSN), which is involved in various cellular and developmental processes. The CSN complex acts as an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of cullin subunits in SCF-type E3 ligase complexes (e.g., SCF, CSA, or DDB2), thereby reducing their Ubl ligase activity. The complex may also participate in the phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, and IRF8, potentially through its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects their degradation by the Ubl system, respectively. Within the complex, JAB1 likely serves as the catalytic center for cleaving Nedd8 from cullins, though it lacks intrinsic metalloprotease activity and relies on other CSN subunits. JAB1 directly interacts with numerous proteins regulated by the CSN complex, highlighting its pivotal role, and promotes the proteasomal degradation of BRSK2.
Gene ID
SwissProt ID
Synonyms
COPS5; CSN5; JAB1; COP9 signalosome complex subunit 5; SGN5; Signalosome subunit 5; Jun activation domain-binding protein 1
Molecular Weight

Predicted band size: 38 kDa; Observed band size: 38 kDa
Purity

Affinity Chromatography
Conjugation

Non-conjugated
Modification

Unmodified
RRID
Research Field

Cell Biology
Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality

Recombinant, Monoclonal
Host

Rabbit
Reactivity

Human, Mouse, Rat
Dilution Ratio

WB: 1/500-1/1000;IHC: 1/50-1/100;IF: 1/50-1/200;IP: 1/50
Application

WB, IHC-P, ICC/IF, IP
Appearance

Liquid
Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

A synthesized peptide derived from human JAB1
Database

Entrez Gene: 10987 Human ; 26754 Mouse ; 312916 Rat

SwissProt: Q92905 Human ; O35864 Mouse ;

OMIM: 604850 Human

Documentation
SDS (251 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)

JAB1 Antibody (YA3159) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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JAB1 Antibody (YA3159)
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HY-P83414
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