EphA5 Antibody (YA4833)

EphA5 Antibody (YA4833) is a mouse-derived and non-conjugated monoclonal antibody, targeting to EphA5. It can be applicated for WB, ELISA assays, in the background of human.

The EPHA5 protein, a receptor tyrosine kinase, engages in promiscuous binding to GPI-anchored ephrin-A family ligands on adjacent cells, initiating contact-dependent bidirectional signaling. The downstream pathway originating from the receptor is known as forward signaling, while the pathway downstream of the ephrin ligand is termed reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is likely the cognate/functional ligand for EPHA5. EPHA5 functions as an axon guidance molecule during development and may be involved in shaping the retinotectal, entorhino-hippocampal, and hippocamposeptal pathways. Together with EFNA5, it plays a role in synaptic plasticity in the adult brain by regulating synaptogenesis. Beyond its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells, contributing to the regulation of glucose-stimulated insulin secretion.

P54756

Predicted band size: 115 kDa;

affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

WB: 1:500-1:2000; ELISA: 1:10000

WB, ELISA

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant fragment of EphA5 (aa620-774) expressed in E. Coli.