2. PROTAC Epigenetics
  3. Epigenetic Reader Domain PROTACs
  4. dBRD 9-A

dBRD 9-A is a PROTAC which can selective degrade BRD9. dBRD 9-A improves the bromine domain binding profile and reduces the binding activity of the whole BET family.

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dBRD 9-A

dBRD 9-A Chemical Structure

CAS No. : 2170679-42-0

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dBRD 9-A Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

dBRD 9-A is a PROTAC which can selective degrade BRD9. dBRD 9-A improves the bromine domain binding profile and reduces the binding activity of the whole BET family[1].

Molecular Weight

779.88

Formula

C42H49N7O8
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C2=C(C(C3=CC(OC)=C(CN(CC(NCCCCCCCCNC4=CC=CC(C(N5C6C(NC(CC6)=O)=O)=O)=C4C5=O)=O)C)C(OC)=C3)=CN1C)C=CN=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (128.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2822 mL 6.4112 mL 12.8225 mL
5 mM 0.2564 mL 1.2822 mL 2.5645 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.50%

SDS (251 KB)

COA (244 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2822 mL 6.4112 mL 12.8225 mL 32.0562 mL
5 mM 0.2564 mL 1.2822 mL 2.5645 mL 6.4112 mL
10 mM 0.1282 mL 0.6411 mL 1.2822 mL 3.2056 mL
15 mM 0.0855 mL 0.4274 mL 0.8548 mL 2.1371 mL
20 mM 0.0641 mL 0.3206 mL 0.6411 mL 1.6028 mL
25 mM 0.0513 mL 0.2564 mL 0.5129 mL 1.2822 mL
30 mM 0.0427 mL 0.2137 mL 0.4274 mL 1.0685 mL
40 mM 0.0321 mL 0.1603 mL 0.3206 mL 0.8014 mL
50 mM 0.0256 mL 0.1282 mL 0.2564 mL 0.6411 mL
60 mM 0.0214 mL 0.1069 mL 0.2137 mL 0.5343 mL
80 mM 0.0160 mL 0.0801 mL 0.1603 mL 0.4007 mL
100 mM 0.0128 mL 0.0641 mL 0.1282 mL 0.3206 mL
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dBRD 9-A Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

dBRD 9-A2170679-42-0Epigenetic Reader DomainPROTACsPROTACBRD9degraderBETInhibitorinhibitorinhibit

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