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2,4'-DDE-d<sub>8</sub>

" in MedChemExpress (MCE) Product Catalog:

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By Research Areas:	Cancer (1976) Cardiovascular Disease (411) Endocrinology (289) Infection (777) Inflammation/Immunology (758) Metabolic Disease (707) Neurological Disease (803)
Click Chemistry:	TCO (3) Labeling and Fluorescence Imaging (2) DBCO (4) PROTAC Synthesis (11) Azide (31) Tetrazine (7) Alkynes (29)
Oligonucleotides:	miRNA mimics (6) Nucleosides and their Analogs (25) miRNA antagomirs (6) Nucleoside Phosphoramidites (1) Rat Pre-designed siRNA Sets (16) Phospholipids (4) miRNA inhibitors (6) Antisense Oligonucleotides (2) Cholesterol (1) siRNAs (79) miRNA agomirs (6) MicroRNAs (24) CpG ODNs (5) Mouse Pre-designed siRNA Sets (17) Cationic Lipids (1) Human Pre-designed siRNA Sets (46)

6203

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

177

Biochemical Assay Reagents

133

Peptides

Inhibitory Antibodies

349

Natural
Products

166

Recombinant Proteins

3899

Isotope-Labeled Compounds

Antibodies

Click Chemistry

142

Oligonucleotides

Targets Recommended: MCHR1 (GPR24) P-glycoprotein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W653849

2,4-Xylidine-d6 2,4-Dimethylaniline-d<sub>6sub>	Isotope-Labeled Compounds	Others
2,4-Xylidine-d₆ is a deuterated labeled 2,4-Xylidine .

HY-121779S

2,4’-DDE-d8	Isotope-Labeled Compounds	Others
2,4'-DDE-d₈ is the deuterium labeled 2,4’-DDE .

HY-B1986S

*p,p'-DDE-d8* 4,4'-DDE-d<sub>8sub>; p,p'-Dichlorodiphenyldichloroethylene-d<sub>8sub>	Androgen Receptor Drug Metabolite	Endocrinology
p,p'-DDE-d₈ is the deuterium labeled p,p'-DDE . p,p'-DDE (4,4'-DDE), a major metabolite of persistent dichlorodiphenyltrichloroethane (DDT), is a potent androgen receptor antagonist, with an IC₅₀ of 5 μM and a K_i of 3.5 μM .

HY-W583271

*Zn(II) Deuteroporphyrin IX 2,4* bis ethylene glycol**	Vasopressin Receptor Biochemical Assay Reagents	Metabolic Disease
Zn(II) Deuteroporphyrin IX 2,4 bis ethylene glycol is a heme oxygenase (HO) inhibitor, and inhibiting HO activity can reduce the release of hypothalamic hormones like AVP, OT, and ANP caused by hyperosmolarity. Zn(II) Deuteroporphyrin IX 2,4 bis ethylene glycol can be used for research on hyperbilirubinemia .

HY-RS13999

SUB1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SUB1 Human Pre-designed siRNA Set A contains three designed siRNAs for SUB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SUB1 Human Pre-designed siRNA Set A SUB1 Human Pre-designed siRNA Set A

HY-RS18793

Sub1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sub1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sub1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sub1 Mouse Pre-designed siRNA Set A Sub1 Mouse Pre-designed siRNA Set A

HY-RS25282

Sub1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sub1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sub1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sub1 Rat Pre-designed siRNA Set A Sub1 Rat Pre-designed siRNA Set A

HY-146227

DNA topoisomerase II inhibitor 1	Topoisomerase Apoptosis	Cancer
DNA topoisomerase II inhibitor 1 (compound 8ed) is a potent DNA topoisomerase II inhibitor. DNA topoisomerase II inhibitor 1 shows anti-proliferative activity. DNA topoisomerase II inhibitor 1 induces apoptosis and cell cycle arrest at sub G1 phase .

HY-13690S2

Mitotane-d8 2,4′-DDD-d<sub>8sub>; o,p'-DDD-d<sub>8sub>	Apoptosis	Cancer
Mitotane-d₈ is the deuterium labeled Mitotane . Mitotane (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions .

HY-13011S

Alectinib-d8 CH5424802-d<sub>8sub>; RO5424802-d<sub>8sub>; AF802-d<sub>8sub>	Isotope-Labeled Compounds Anaplastic lymphoma kinase (ALK)	Cancer
Alectinib-d₈ is the deuterium labeled Alectinib. Alectinib (CH5424802) is a potent, selective, and orally available ALK inhibitor with an IC₅₀ of 1.9 nM and a Kd value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC₅₀s of 1 nM and 3.5 nM, respectively . Alectinib demonstrates effective central nervous system (CNS) penetration .

HY-W280214S1

Nonylbenzene-d24 1-Phenylnonane-d<sub>24sub>	Isotope-Labeled Compounds	Others
Nonylbenzene-d₂₄ is the deuterium labeled Nonylbenzene .

HY-18572S

2,4-D-13C6 2,4-Dichlorophenoxyacetic acid-¹³C<sub>6sub>	Isotope-Labeled Compounds DNA/RNA Synthesis	Others
2,4-D- ¹³C₆ is the ¹³C-labeled 2,4-D. 2,4-D (2,4-Dichlorophenoxyacetic acid) is a selective systemic herbicide for the control of broad-leaved weeds. 2,4-D acts as a plant hormone, causing uncontrolled growth in the meristematic tissues. 2,4-D inhibits DNA and protein synthesis and thereby prevents normal plant growth and development .

HY-W010420S

2,4-Difluoro-1-methylbenzene-d3 2,4-Difluorotoluene-d<sub>3sub>	Isotope-Labeled Compounds	Others
2,4-Difluoro-1-methylbenzene-d₃ is the deuterium labeled 2,4-Difluoro-1-methylbenzene .

HY-W009981S

*1-Bromo-2,4-difluorobenzene-d3* 2,4-Difluorobromobenzene-d<sub>3sub>	Isotope-Labeled Compounds	Others
1-Bromo-2,4-difluorobenzene-d₃ is the deuterium labeled 1-Bromo-2,4-difluorobenzene .

HY-17367S5

Atazanavir-d24 BMS-232632-d<sub>24sub>	Isotope-Labeled Compounds P-glycoprotein SARS-CoV Endogenous Metabolite HIV Cytochrome P450 HIV Protease Toll-like Receptor (TLR)	Infection Cardiovascular Disease Cancer
Atazanavir-d₂₄ (BMS-232632-d₂₄) is deuterium labeled Atazanavir. Atazanavir (BMS-232632) is a highly selective and orally active HIV-1 protease inhibitor . Atazanavir is a substrate and inhibitor of CYP3A4, and an inhibitor of P-glycoprotein (P-gp). Atazanavir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 3.49 μM. Atazanavir inhibits cardiac fibrosis, hyperlipidemia and induces malignant glioma death ^[8].

HY-P5571

Aurein 2.4	Antibiotic Bacterial	Infection
Aurein 2.4 is an antibiotic antimicrobial peptide. Aurein 2.4 is active against Gram-positive bacterial .

HY-W014223S1

2,4′-Dihydroxybenzophenone-d5 Ultraviolet absorber UV-0-d<sub>5sub>	Isotope-Labeled Compounds	Others
(2,4-Dihydroxyphenyl)(phenyl)methanone-d₅ is the deuterium labeled (2,4-Dihydroxyphenyl)(phenyl)methanone .

HY-W001955S

2-(4-Fluorophenyl)acetic acid-d2 p-Fluorophenylacetic acid-d<sub>2sub>	Isotope-Labeled Compounds	Others
2-(4-Fluorophenyl)acetic acid-d₂ is the deuterium labeled 2-(4-Fluorophenyl)acetic acid .

HY-10844S1

Pretomanid-d5 PA-824-d<sub>5sub>; (S)-PA 824-d<sub>5sub>	Antibiotic Bacterial Isotope-Labeled Compounds	Infection Cancer
Pretomanid-d₅ is deuterated labeled Pretomanid (HY-10844). Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.

HY-P10215

Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2	Parasite	Infection
Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2 (compound 40) is a potent **Plasmodium subtilisin-like protease 1 (SUB1)** inhibitor. SUB1-IN-1 shows IC₅₀ values of 12 nM and 10 nM against P. vivax and P. falciparum SUB1 (Pv- and PfSUB1), respectively .

HY-W014779S

Dodecane-1,12-diol-d24 Dodecamethylene glycol-d<sub>24sub>	Isotope-Labeled Compounds	Others
Dodecane-1,12-diol-d₂₄ is the deuterium labeled Dodecane-1,12-diol .

HY-W014223S

2,4-Dihydroxybenzophenone-13C6 Ultraviolet absorber UV-0-¹³C<sub>6sub>	Isotope-Labeled Compounds	Others
2,4-Dihydroxybenzophenone- ¹³C₆ (Ultraviolet absorber UV-0- ¹³C₆) is the ¹³C- and deuterium labeled (2,4-Dihydroxyphenyl)(phenyl)methanone .

HY-17037S1

Pirenzepine-d8 dihydrochloride LS 519-d<sub>8sub> dihydrochloride; Pirenzepin-d<sub>8sub> dihydrochloride; Gastrozepin-d<sub>8sub> dihydrochloride	Isotope-Labeled Compounds mAChR	Cancer
Pirenzepine-d₈ (LS 519-d₈; Pirenzepin-d₈) dihydrochloride is a deuterium labeled Pirenzepine (dihydrochloride) (HY-17037). Pirenzepine (LS 519) dihydrochloride is a selective M1 mAChR (muscarinic acetylcholine receptor) antagonist. Pirenzepine dihydrochloride reduces gastric acid secretion and reduces muscle spasm, can be used in peptic ulcers research. Pirenzepine dihydrochloride shows anti-proliferative activity to cancer cells .

HY-G0021S

N-Desmethylclozapine-d8 Norclozapine-d<sub>8sub>; Desmethylclozapine-d<sub>8sub>; Normethylclozapine-d<sub>8sub>	mAChR Opioid Receptor Drug Metabolite Virus Protease	Infection
N-Desmethylclozapine-d₈ is the deuterium labeled N-Desmethylclozapine. N-Desmethylclozapine is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine is a potent, allosteric and partial M1 receptors agonist (EC₅₀=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine is also a δ-opioid agonist .

HY-G0021S1

N-Desmethylclozapine-d8 hydrochloride Norclozapine-d<sub>8sub> hydrochloride; Desmethylclozapine-d<sub>8sub> hydrochloride; Normethylclozapine-d<sub>8sub> hydrochloride	mAChR Opioid Receptor Drug Metabolite Virus Protease	Infection
N-Desmethylclozapine-d₈ (hydrochloride) is the deuterium labeled N-Desmethylclozapine hydrochloride. N-Desmethylclozapine hydrochloride is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine hydrochloride is a potent, allosteric and partial M1 receptors agonist (EC₅₀=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine hydrochloride is also a δ-opioid agonist .

HY-B0615AS

Moricizine-d8(Hydrochloride) EN 313-d<sub>8sub>; Ethmozin-d<sub>8sub>; Moracizine-d<sub>8sub>	Isotope-Labeled Compounds	Cardiovascular Disease
Moricizine-d₈ (Hydrochloride) is the deuterium labeled Moricizine Hydrochloride (HY-B0615A). Moricizine Hydrochloride is an orally active Class I antiarrhythmic agent. Moricizine Hydrochloride decreases the maximum rate of phase 0 depolarization; increases rates of phase 2 and 3 repolarization, decreases action potential duration, and decreases effective refractory period .

HY-B0454AS

*Miconazole-d5 nitrate (2,4-Dichlorobenzyloxy-d5)* R18134-d<sub>5sub> nitrate (2,4-Dichlorobenzyloxy-d<sub>5sub>)	Fungal Bacterial Antibiotic	Infection
Miconazole-d₅ (nitrate) (2,4-Dichlorobenzyloxy-d₅) is the deuterium labeled Miconazole nitrate. Miconazole nitrate (R18134 nitrate) is an imidazole antifungal agent. Miconazole nitrate also has antibacterial effects .

HY-50878S1

Crizotinib-d8 PF-02341066-d<sub>8sub>	Isotope-Labeled Compounds ROS Kinase Autophagy c-Met/HGFR Anaplastic lymphoma kinase (ALK)	Cancer
Crizotinib-d₈ (PF-02341066-d₈) is deuterium labeled Crizotinib. Crizotinib (PF-02341066) is an orally bioavailable, ATP-competitive ALK and c-Met inhibitor with IC₅₀s of 20 and 8 nM, respectively. Crizotinib inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC₅₀s of 24 and 11 nM in cell-based assays, respectively. Crizotinib is also a ROS1 inhibitor. Crizotinib has effective tumor growth inhibition .

HY-50896S3

Erlotinib-d8 CP-358774-d<sub>8sub>; NSC 718781-d<sub>8sub>; OSI-774-d<sub>8sub>	Isotope-Labeled Compounds	Cancer
Erlotinib-d₈ (CP-358774-d₈) is deuterium labeled Erlotinib. Erlotinib (CP-358774) is a directly acting EGFR tyrosine kinase inhibitor, with an IC₅₀ of 2 nM for human EGFR. Erlotinib reduces EGFR autophosphorylation in intact tumor cells with an IC₅₀ of 20 nM. Erlotinib is used for the treatment of non-small cell lung cancer . Erlotinib is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-15531S

Venetoclax-d8 ABT-199-d<sub>8sub>; GDC-0199-d<sub>8sub>; RG7601-d<sub>8sub>	Bcl-2 Family Autophagy	Cancer
Venetoclax-d₈ is deuterium labeled Venetoclax. Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a K_i of less than 0.01 nM. Venetoclax induces autophagy .

HY-14740S

Elvitegravir-d8 GS-9137-d<sub>8sub>; JTK-303-d<sub>8sub>; D06677-d<sub>8sub>	Isotope-Labeled Compounds HIV Integrase HIV	Infection
Elvitegravir-d₈ is deuterium labeled Elvitegravir. Elvitegravir (GS-9137; JTK-303; D06677) is an HIV integrase inhibitor for HIV-1IIIB, HIV-2EHO and HIV-2ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM, respectively.

HY-17037S

Pirenzepine-d8 LS 519-d<sub>8sub> free base; Pirenzepin-d<sub>8sub>; Gastrozepin-d<sub>8sub>	Isotope-Labeled Compounds mAChR	Neurological Disease Inflammation/Immunology
Pirenzepine-d₈ is the deuterium labeled Pirenzepine dihydrochloride. Pirenzepine dihydrochloride (LS519) is a selective M1 muscarinic receptor antagonist.

HY-10227S

Bortezomib-d8 PS-341-d<sub>8sub>; LDP-341-d<sub>8sub>; NSC 681239-d<sub>8sub>	Proteasome NF-κB Apoptosis Autophagy	Cancer
Bortezomib-d₈ is the deuterium labeled Bortezomib. Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is the first proteasome inhibitor anticancer agent. Anti-cancer activity .

HY-10570S2

Nevirapine-d8 BI-RG 587-d<sub>8sub>; NSC 641530-d<sub>8sub>; NVP-d<sub>8sub>	Isotope-Labeled Compounds Reverse Transcriptase Parasite HIV	Infection Cancer
Nevirapine-d₈ (BI-RG 587-d₈) is deuterium labeled Nevirapine. Nevirapine is a non-nucleoside inhibitor of HIV-1 reverse transcriptase used to treat and prevent HIV/AIDS; with a K_i of 270 μM .

HY-13463BS

Avatrombopag-d8 hydrochloride AKR-501-d<sub>8sub> hydrochloride; E5501-d<sub>8sub> hydrochloride; YM477-d<sub>8sub> hydrochloride	Isotope-Labeled Compounds Thrombopoietin Receptor	Cardiovascular Disease
Avatrombopag-d₈ (hydrochloride) is deuterium labeled Avatrombopag (hydrochloride). Avatrombopag (AKR-501) hydrochloride is an orally active, nonpeptide thrombopoietin (TPO) receptor agonist (EC₅₀=3.3 nM). Avatrombopag hydrochloride mimics the biological activities of TPO. Avatrombopag hydrochloride increases platelet production by activating the intracellular signaling system, and promotes production of platelets and megakaryocytes from hemopoietic precursor cells. Avatrombopag hydrochloride is a substrate of cytochrome P450 (CYP) 2C9 and CYP3A .

HY-B0966S

Dioxybenzone-d3 Benzophenone-8-d<sub>3sub>; UV-24-d<sub>3sub>	Isotope-Labeled Compounds Biochemical Assay Reagents	Inflammation/Immunology Cancer
Dioxybenzone-d₃ is deuterium labeled Dioxybenzone. Dioxybenzone (Benzophenone-8; UV-24) is an organic compound used to block UVB and short-wave UVA (ultraviolet) radiation. Dioxybenzone has orally activity. Dioxybenzone exhibits estrogenic disrupting effect. Dioxybenzone up-regulates inflammatory cytokines. Dioxybenzone can be used for cancer, reproductive system disease and inflammatory disease study .

HY-15581S

MMAD-d8 Demethyldolastatin 10-d<sub>8sub>; Monomethylauristatin D-d<sub>8sub>; Monomethyl Dolastatin 10-d<sub>8sub>	ADC Cytotoxin Microtubule/Tubulin	Cancer
MMAD-d₈D is a deuterated form of MMAD, which is a microtubule disrupting agent.

HY-Y1309S

1-Naphthol-d8 Furro ER-d<sub>8sub>; NSC 9586-d<sub>8sub>; Nako TRB-d<sub>8sub>	Endogenous Metabolite	Others
1-Naphthol-d₈ is the deuterium labeled 1-Naphthol . 1-naphthol is an excited state proton transfer (ESPT) fluorescent molecular probe .

HY-N0623S5

L-Tryptophan-d8 Tryptophan-d<sub>8sub>; Tryptophane-d<sub>8sub>	Endogenous Metabolite	Metabolic Disease
L-Tryptophan-d₈ is the deuterium labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3 .

HY-B0272S1

Rifampicin-d8 Rifampin-d<sub>8sub>; Rifamycin AMP-d<sub>8sub>	Bacterial Influenza Virus Antibiotic	Infection
Rifampicin-d8 (Rifampin-d8) is the deuterium labeled Rifampicin. Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities.

HY-N0378S

D-Mannitol-d8 Mannitol-d<sub>8sub>; Mannite-d<sub>8sub>	Endogenous Metabolite Apoptosis	Metabolic Disease
D-Mannitol-d₈ is the deuterium labeled D-Mannitol. D-Mannitol is an osmotic diuretic agent and a weak renal vasodilator.

HY-N0007S

Bisdemethoxycurcumin-d8 Curcumin III-d<sub>8sub>; Didemethoxycurcumin-d<sub>8sub>	Isotope-Labeled Compounds Ferroptosis P-glycoprotein DNA/RNA Synthesis	Inflammation/Immunology Cancer
Bisdemethoxycurcumin-d₈ (Curcumin III-d₈) is the deuterium labeled Bisdemethoxycurcumin (HY-N0007A). Bisdemethoxycucurmin (Curcumin III) is a curcuminoid compound and an inhibitor of P-glycoprotein and ferroptosis. Bisdemethoxycucurmin exhibits multiple activities such as anti-oxidation, anti-inflammation and anti-tumor. Bisdemethoxycucurmin can be used for the research of tumors and inflammatory diseases .

HY-B0104S2

Glimepiride-d8 Glimperide-d<sub>8sub>; HOE-490-d<sub>8sub>	Amyloid-β Isotope-Labeled Compounds	Metabolic Disease
Glimepiride-d₈ (Glimperide-d₈; HOE-490-d₈) is deuterium-labeled Glimepiride (HY-B0104) .

HY-13502AS

Mitoxantrone-d8 dihydrochloride Mitozantrone-d<sub>8sub>(dihydrochloride); NSC 301739-d<sub>8sub> dihydrochloride	Endogenous Metabolite PKC Apoptosis Topoisomerase Orthopoxvirus Isotope-Labeled Compounds	Infection Cancer
Mitoxantrone-d₈ dihydrochloride is deuterated labeled Mitoxantrone dihydrochloride (HY-13502A). Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC₅₀ of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity . Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC₅₀s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .

HY-B0246S2

Carbamazepine-d8 CBZ-d<sub>8sub>; NSC 169864-d<sub>8sub>	Isotope-Labeled Compounds Sodium Channel Autophagy Mitophagy	Neurological Disease Cancer
Carbamazepine-d₈ is the deuterium labeled Carbamazepine. Carbamazepine, a sodium channel blocker, is an anticonvulsant agent, with an IC₅₀ of 131 μM .

HY-13502AS1

Mitoxantrone-d8 hydrochloride Mitozantrone-d<sub>8sub> hydrochloride; NSC 301739-d<sub>8sub> hydrochloride	Isotope-Labeled Compounds Endogenous Metabolite Apoptosis Orthopoxvirus PKC Topoisomerase	Infection Cancer
Mitoxantrone-d₈ (hydrochloride) (Mitozantrone-d₈ (hydrochloride)) is deuterium labeled Mitoxantrone (dihydrochloride). Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC₅₀ of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity . Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC₅₀s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .

HY-90001S2

Ritonavir-d8 ABT 538-d<sub>8sub>; RTV-d<sub>8sub>	Apoptosis HIV Protease SARS-CoV HIV Isotope-Labeled Compounds	Infection Cancer
Ritonavir-d₈ is deuterated labeled Ritonavir (HY-90001). Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 1.61 μM.

HY-13502S

Mitoxantrone-d8 Mitozantrone-d<sub>8sub>; NSC 301739-d<sub>8sub>	Isotope-Labeled Compounds Topoisomerase PKC	Cancer
Mitoxantrone-d₈ (mitozantrone-d₈) is the deuterium labeled Mitoxantrone. Mitoxantrone is a topoisomerase II inhibitor and also inhibits protein kinase C (PKC) activity with an IC₅₀ of 8.5 μM .

HY-B1970S

o,p'-DDT-d8 2,4'-DDT-d<sub>8sub>	Isotope-Labeled Compounds	Others
o,p'-DDT-d₈ is the deuterium labeled o,p'-DDT .

HY-B1955S

4',4-Dibromobiphenyl-d8 NSC 2098-d<sub>8sub>; PBB 15-d<sub>8sub>; p,p'-Dibromobiphenyl-d<sub>8sub>	Isotope-Labeled Compounds	Others
4',4-Dibromobiphenyl-d₈ is the deuterium labeled 4',4-Dibromobiphenyl[1].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-125833

Alpha-Naphthoflavone 5+ Cited Publications	Flavonoids Flavones Source classification Indigofera heterantha Wall. ex Brand. Plants Compositae Disease Research Fields Cancer	Cytochrome P450 Aryl Hydrocarbon Receptor Apoptosis
Alpha-Naphthoflavone is an orally active flavonoid that is a potent, competitive inhibitor of aromatase< b>aromatase. < b > IC < sub > 50 < / sub > < / b > and < b > K < sub > I < / sub > < / b > value were 0.5 and 0.2 microns. Alpha-Naphthoflavone can inhibit cell proliferation and induce apoptosis .

HY-18572

2,4-D 2,4-Dichlorophenoxyacetic acid	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields Biological Pesticide Research Agricultural Research	DNA/RNA Synthesis Apoptosis
2,4-D (2, 4-dichlorophenoxyacetic acid) is a selective herbicide that can be orally active for the control of broad-leaved weeds. 2,4-D can induce apoptosis. 2,4-D inhibits DNA and protein synthesis, thereby preventing normal plant growth and development .

HY-16940

24(S)-Hydroxycholesterol 24S-OHC; 24S-HC; Cerebrosterol	Structural Classification Classification of Application Fields Source classification Disease markers Metabolic Disease Nervous System Disorder Endogenous metabolite Disease Research Fields Steroids	LXR iGluR Endogenous Metabolite
24(S)-Hydroxycholesterol (24S-OHC), the major brain cholesterol metabolite, plays an important role to maintain homeostasis of cholesterol in the brain. 24(S)-Hydroxycholesterol (24S-OHC) is one of the most efficient endogenous LXR agonist known and is present in the brain and in the circulation at relatively high levels. 24(S)-Hydroxycholesterol (24S-OHC) is a very potent, direct, and selective positive allosteric modulator of NMDARs with a mechanism that does not overlapthat of other allosteric modulators .

HY-N10455

24-Epicastasterone 2 Publications Verification 24-epi-Castasterone	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Other Diseases Brassinolide Phytohormone Disease Research Fields Agricultural Research	Others
24-Epicastasterone (24-epi-Castasterone), a brassinosteroid, is a nature product that could be isolated from Hydrodictyon reticulatwn .

HY-118448

2,4-Diacetylphloroglucinol	Microorganisms Source classification	Antibiotic Bacterial Fungal Parasite
2,4-Diacetylphloroglucinol is a polyketide antibiotic produced by Pseudomonas fluorescens. 2,4-Diacetylphloroglucinol exhibits broad-spectrum toxicity against various organisms such as bacteria, fungi, oomycetes, and nematodes. 2,4-Diacetylphloroglucinol can also inhibit plant pathogens and affect the root development of tomato seedlings .

HY-N11799

Neochilenin 3-O-Methylquercetin 4′-O-glucoside	Structural Classification Flavonoids Source classification Plants Compositae Other Flavonoids	Others
Neochilenin (3-O-Methylquercetin 4 '-O-glucoside) is a glycoside of 3-O-methylquercetin, which can be isolated from the sub-family Cereoideae (Cactaceae). .

HY-W007539R

2,4-Dihydroxybenzaldehyde (Standard)	Monophenols Ketones, Aldehydes, Acids Source classification Phenols Polyphenols Endogenous metabolite	Endogenous Metabolite
2,4-Dihydroxybenzaldehyde (Standard) is the analytical standard of 2,4-Dihydroxybenzaldehyde. This product is intended for research and analytical applications. 2,4-Dihydroxybenzaldehyde is an endogenous metabolite.

HY-18572R

2,4-D (Standard)	Ketones, Aldehydes, Acids Source classification Endogenous metabolite	DNA/RNA Synthesis Apoptosis
2,4-D (Standard) is the analytical standard of 2,4-D. This product is intended for research and analytical applications. 2,4-D (2, 4-dichlorophenoxyacetic acid) is a selective herbicide that can be orally active for the control of broad-leaved weeds. 2,4-D can induce apoptosis. 2,4-D inhibits DNA and protein synthesis, thereby preventing normal plant growth and development .

HY-118448R

2,4-Diacetylphloroglucinol (Standard)	Microorganisms Source classification	Antibiotic Bacterial Fungal Parasite
2,4-Diacetylphloroglucinol (Standard) is the analytical standard of 2,4-Diacetylphloroglucinol (HY-118448). This product is intended for research and analytical applications. 2,4-Diacetylphloroglucinol is a polyketide antibiotic produced by Pseudomonas fluorescens. 2,4-Diacetylphloroglucinol exhibits broad-spectrum toxicity against various organisms such as bacteria, fungi, oomycetes, and nematodes. 2,4-Diacetylphloroglucinol can also inhibit plant pathogens and affect the root development of tomato seedlings .

HY-100821

2,4-Dihydroxyphenylacetylasparagine	Structural Classification Animals Ketones, Aldehydes, Acids Source classification Phenols	Bacterial
2,4-Dihydroxyphenylacetylasparagine is a potent and selective antagonist of glutamate. 2,4-Dihydroxyphenylacetylasparagine inhibits glutamate binding to rat brain synaptic membranes .

HY-W014589R

2,4-Di-tert-butylphenol (Standard) 2,4-DTBP (Standard)	Structural Classification Monophenols Microorganisms Source classification Phenols Endogenous metabolite	Endogenous Metabolite Fungal Apoptosis RAR/RXR Amyloid-β
2,4-Di-tert-butylphenol (Standard) is the analytical standard of 2,4-Di-tert-butylphenol (HY-W014589). This product is intended for research and analytical applications. 2,4-Di-tert-butylphenol (2,4-DTBP) is an orally active RXRα activator and a human estrogen receptor ligand with anti-inflammatory and antioxidant activities, which can induce apoptosis in tumor cells. 2,4-Di-tert-butylphenol can activate the RXRα subtype in LXRα/RXRα, PPARγ/RXRα, and hormone receptor β/RXRα. 2,4-Di-tert-butylphenol also has antiviral and antifungal activities, and has the potential to inhibit Aβ-induced neurotoxicity. 2,4-Di-tert-butylphenol can be used as an intermediate in the preparation of antioxidants and UV stabilizers, and is also used in the manufacture of pharmaceuticals and fragrances .

HY-W014589

2,4-Di-tert-butylphenol 1 Publications Verification 2,4-DTBP	Structural Classification Monophenols Microorganisms Classification of Application Fields Source classification Phenols Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Fungal Apoptosis RAR/RXR Amyloid-β
2,4-Di-tert-butylphenol (2,4-DTBP) is an orally active RXRα activator and a human estrogen receptor ligand with anti-inflammatory and antioxidant activities, which can induce apoptosis in tumor cells. 2,4-Di-tert-butylphenol can activate the RXRα subtype in LXRα/RXRα, PPARγ/RXRα, and hormone receptor β/RXRα. 2,4-Di-tert-butylphenol also has antiviral and antifungal activities and has the potential to inhibit Aβ-induced neurotoxicity. 2,4-Di-tert-butylphenol can be used as an intermediate in the preparation of antioxidants and UV stabilizers, and is also used in the manufacture of drugs and fragrances .

HY-Y0694

2',4'-Dihydroxyacetophenone Resacetophenone; 1-(2,4-Dihydroxyphenyl)ethanone	Structural Classification Classification of Application Fields Source classification Other Diseases Phenols Polyphenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite COX
2',4'-Dihydroxyacetophenone (Resacetophenone) is acetophenone carrying hydroxy substituents at positions 2' and 4'. 2',4'-Dihydroxyacetophenone involves in a practical CsHCO₃-mediated alkylation that efficiently provide 4-alkylated products with excellent regioselectivity, good isolated yields and a broad substrate scope. 2',4'-Dihydroxyacetophenone is a plant metabolite .

HY-W012575R

2,4-Dihydroxybenzoic acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Phenols Polyphenols Endogenous metabolite	Reactive Oxygen Species
2,4-Dihydroxybenzoic acid (Standard) is the analytical standard of 2,4-Dihydroxybenzoic acid (HY-W012575). This product is intended for research and analytical applications. 2,4-Dihydroxybenzoic acid is a degradation product of acid cherry anthocyanins during in vitro cell culture and an analogue of coenzyme Q precursor molecules. 2,4-Dihydroxybenzoic acid can improve the related symptoms of kidney diseases caused by ADCK4/Coq6 deficiency .

HY-W015618

2',4'-Dimethylacetophenone	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
2',4'-Dimethylacetophenone is an endogenous metabolite.

HY-W007539

2,4-Dihydroxybenzaldehyde	Monophenols Ketones, Aldehydes, Acids Source classification Phenols Polyphenols Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
2,4-Dihydroxybenzaldehyde is an endogenous metabolite.

HY-W011474

Geranylgeraniol	Structural Classification Natural Products Microorganisms	NF-κB
Geranylgeraniol is an orally acitve vitamin K₂ sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model .

HY-N3660

(24S)-Cycloartane-3,24,25-triol 24,25-acetonide	Triterpenes Structural Classification Terpenoids Source classification Plants Meliaceae Aphanamixis polystachya (Wall.) R. N. Parker	Others
(24S)-Cycloartane-3,24,25-triol 24,25-acetonide is a Triterpenoids product that can be isolated from the barks of Aphanamixis polystachya .

HY-N1703

24-Methylenecycloartanol	Triterpenes Structural Classification Terpenoids Gramineae Source classification Oryza sativa L. Plants	Others
24-Methylenecycloartanol is a compound that can be isolated from Ficus krishnae. 24-Methylenecycloartanol can be used for the research of diabetes .

HY-N12467

24-Methylcholesterol	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	Others
24-Methylcholesterol is a trans-ferulate ester that can be isolated from rice bran. 24-Methylcholesterol significantly inhibited TPA-induced inflammation .

HY-N0853A

Alisol A 24-acetate 1 Publications Verification Alisol A 24-monoacetate; Alisol A monoacetate	Triterpenes Structural Classification Alisma plantago-aquatica Linn. Classification of Application Fields Terpenoids Source classification Other Diseases Alismataceae Plants Disease Research Fields	Others
Alisol A 24-acetate (Alisol A 24-monoacetate) is a natural product.

HY-137330

*S-(2,4-Dinitrophenyl)glutathione*	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
S-(2,4-Dinitrophenyl)glutathione is a substrate for glutathione-S-transferase. (2,4-Dinitrophenyl)glutathione can be used as an irreversible glutathione reductase inhibitor with an K_i value of 30 µM .

HY-N3661

(24S)-Cycloartane-3β,24,25-triol	Triterpenes Structural Classification Terpenoids Source classification Dendranthema morifolium (Ramat.) Tzvel. Plants Compositae	Bacterial
(24S)-Cycloartane-3β,24,25-triol, a cycloartane, has antitubercular activity against Mycobacterium tuberculosis H37Rv (MIC: 32 μg/mL). (24S)-Cycloartane-3β,24,25-triol can be isolated from the flowers of Chrysanthemum morifolium .

HY-N8122

24-Methylenecycloartanyl ferulate	Triterpenes Structural Classification Monophenols other families Classification of Application Fields Terpenoids Source classification Phenols Plants Disease Research Fields Cancer	Akt
24-Methylenecycloartanyl ferulate is a γ-oryzanol compound. 24-Methylenecycloartanyl ferulate promotes parvin-beta expression in human breast cancer cells. 24-Methylenecycloartanyl ferulate is a potential ATP-competitive Akt1 inhibitor (EC₅₀= 33.3μM) .

HY-N1704

24-Methylenecycloartanol acetate	Euphorbia segetalis L. Triterpenes Structural Classification Terpenoids Source classification Euphorbiaceae Plants	Others
24-Methylenecycloartanol acetate is a triterpene that can be found in Euphorbia segetalis .

HY-N15356

9-Oxooctadecanedioic acid	Structural Classification Ketones, Aldehydes, Acids Source classification Plants Quercus suber L. Fagaceae	Bacterial
9-Oxooctadecanedioic acid is an α,ω-dicarboxylic fatty acid monomer found in the cork suberin of Quercus suber. It contributes to the formation of the hydrophobic barrier structure in plant cell walls and may play an important role in functions such as water resistance and protection against microbial penetration .

HY-W012575

2,4-Dihydroxybenzoic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Phenols Polyphenols Endogenous metabolite Disease Research Fields	Reactive Oxygen Species
2,4-Dihydroxybenzoic acid is a degradation product of acid cherry anthocyanins during in vitro cell culture and an analogue of coenzyme Q precursor molecules. 2,4-Dihydroxybenzoic acid can improve the related symptoms of kidney diseases caused by ADCK4/Coq6 deficiency .

HY-N0960

*(2,4-Dihydroxyphenyl)acetonitrile*	Structural Classification Source classification Phenols Polyphenols Ericaceae Plants Erica scoparia L.	Others
(2,4-Dihydroxyphenyl)acetonitrile is a natural compound found in Erica scoparia .

HY-N12848

24-Hydroxycyasterone	Structural Classification Cyathula officinalis Kuan Cardiacglycosides Source classification Amaranthaceae Plants Steroids	Others
24-Hydroxycyasterone can be isolated from the roots of Cyathula officinalis Kuan .

HY-N0853AR

Alisol A 24-acetate (Standard)	Triterpenes Structural Classification Alisma plantago-aquatica Linn. Terpenoids Source classification Alismataceae Plants	Others
Alisol A 24-acetate (Standard) is the analytical standard of Alisol A 24-acetate. This product is intended for research and analytical applications.

HY-107315

Alisol F 24-acetate	Triterpenes Structural Classification Alisma plantago-aquatica Linn. Terpenoids Source classification Plants Alismataceae	HBV Apoptosis
Alisol F 24-acetate is a triterpene compound that can be isolated from the rhizomes of Alisma orientalis. Alisol F 24-acetate inhibits the secretion of HBV surface antigen HBsAg and HBeAg with IC₅₀ values of 7.7 µM and 5.1 µM. Alisol F 24-acetate has proapoptotic activity and can be used for cancer research .

HY-N8790

24-Methylenecycloartanone	Triterpenes Structural Classification Bistorta officinalis Raf. Terpenoids Polygonaceae Source classification Plants	Others
24-Methylenecycloartanone is a Triterpenoids product that can be isolated from the rhizomes of Polygonum bistorta. .

HY-66047

2,4-Dihydroxypyrimidine-5-carboxylic Acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
2,4-Dihydroxypyrimidine-5-carboxylic Acid is an endogenous metabolite.

HY-N1668

2,4-Dihydroxyphenylacetic acid	Structural Classification Source classification Ranunculaceae Phenols Polyphenols Plants Nigella damascena Linn.	Others
2,4-Dihydroxyphenylacetic acid (compound 3) is a natural product that can be obtained from Nigella damascene L. seeds .

HY-N7516

*4'-Hydroxy-2,4-dimethoxychalcone*	Infection Structural Classification Chalcones Monophenols Flavonoids Classification of Application Fields Source classification Phenols Umbelliferae Plants Disease Research Fields Carphephorus corymbosus (Nutt.) Torr. & A.Gray	Parasite Bacterial Fungal
4'-Hydroxy-2,4-dimethoxychalcone is a natural chalcone derivatives in the red herbal resin of Dracaena cochinchinensis. 4'-Hydroxy-2,4-dimethoxychalcone displays a wide range of biological activities including antimalarial, antiprotozoal, antibacterial, antifungal activity .

HY-P2274

Argifin	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Parasite
Argifin is a sub-nanomolar chitinase inhibitor produced by soil microorganisms, with IC₅₀s of 0.025 μM, 6.4 μM , 1.1 μM and 4.5 μM for SmChiA (Serratia marcescens chitinaese A), SmChiB, Aspergillus fumigatus chitinase B1 and human chitotriosidase, respectively .

HY-N3868

*Ethyl 2,4-dihydroxyphenylacetate*	Structural Classification Source classification Phenols Diploclisia glaucescens (Blume) Diels Plants Menispermaceae	Others
Ethyl 2,4-dihydroxyphenylacetate is a Phenols product that can be isolated from the herbs of Diploclisia glaucescens .

HY-W013627

*trans,trans-2,4-Decadienal*	Structural Classification Natural Products Microorganisms other families Classification of Application Fields Source classification Other Diseases Plants Disease Research Fields	Apoptosis
trans,trans-2,4-Decadienal is a lipid peroxidation product of linolieic acid .

HY-136177R

*Tris(2,4-di-tert-butylphenyl)phosphate (Standard)*	Natural Products Verbenaceae Source classification Plants Vitex negundo Linn.	Phospholipase
Tris(2,4-di-tert-butylphenyl)phosphate (Standard) is the analytical standard of Tris(2,4-di-tert-butylphenyl)phosphate. This product is intended for research and analytical applications. Tris(2,4-di-tert-butylphenyl)phosphate is an active compound from the leaves of Vitex negundo L. shows anti-inflammatory activity with evidence of inhibition for secretory Phospholipase A2 (sPLA2) through molecular docking .

HY-133968

24-Methylenecholesterol Ostreasterol	Structural Classification Classification of Application Fields Anti-aging Marine natural products Source classification Other marine organisms Plants Microorganisms other families Animals Inflammation/Immunology Disease Research Fields Steroids	Acyltransferase Reactive Oxygen Species
24-Methylenecholesterol (Ostreasterol) is a regulator targeting acyl-CoA cholesterol acyltransferase (ACAT) with anti-aging and neuroprotective effects. 24-Methylenecholesterol mimics the effects of nerve growth factor (NGF), can extend yeast lifespan through an anti-oxidative stress mechanism, and exhibits neuroprotective activity in PC12 cells. 24-Methylenecholesterol can reduce intracellular reactive oxygen species (ROS) and malondialdehyde (MDA) levels, activate anti-oxidative stress pathways (such as UTH1, SOD-related genes), and promote synaptic growth .

HY-N8888

10,11-Dihydro-24-hydroxyaflavinine	Natural Products Animals Source classification	Others
10,11-Dihydro-24-hydroxyaflavinine (10,23,24,25-tetrahydro-24-hydroxyaflavinine), an aflavinine analog, is a natural product that can be isolated from Ascostromata of Eupenicillium crustaceum .

HY-N2370

24-Hydroxycholesterol 2 Publications Verification	Structural Classification Animals Source classification Steroids	iGluR LXR
24-Hydroxycholesterol is a natural sterol, which serves as a positive allosteric modulator of N-Methyl-d-Aspartate (NMDA) receptorsR, and a potent activator of the transcription factors LXR.

HY-18646

23,25-Dihydroxy-24-oxovitamin D3 24-Oxo-23,25-dihydroxyvitamin D3	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
23,25-Dihydroxy-24-oxovitamin D3 is a major metabolite of 24(R),25-Dihydroxyvitamin D3. 23,25-Dihydroxy-24-oxovitamin D3 can be used for the research of metabolic diseases .

HY-107238

(3β,24R)-3-(Acetyloxy)eupha-7,25-dien-24-ol	Triterpenes Classification of Application Fields Terpenoids Source classification Other Diseases Plants Moraceae Disease Research Fields Broussonetia papyrifera (Linnaeus) L'Heritier ex Ventenat	Others
(3β,24R)-3-(Acetyloxy)eupha-7,25-dien-24-ol is an euphane triterpene compound isolated from the barks of Broussonetia papyrifera .

HY-N13654

*1,3-Dihydroxy-2,4-diprenylacridone*	Structural Classification Alkaloids Other Alkaloids Source classification Atalantia buxifolia (Poir.) Oliv. Rutaceae Plants	Others
1,3-Dihydroxy-2,4-diprenylacridone is a natural product .

HY-W011474R

Geranylgeraniol (Standard)	Structural Classification Natural Products Microorganisms	NF-κB
Geranylgeraniol (Standard) is the analytical standard of Geranylgeraniol. This product is intended for research and analytical applications. Geranylgeraniol is an orally acitve vitamin K2 sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model [4].

HY-N10192

Aculene D	Infection Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Disease Research Fields	Endogenous Metabolite Bacterial
Aculene D, a fungal metabolite, shows quorum sensing (QS) inhibitory activity against Chromobacterium violaceum CV026, and could significantly reduce violacein production in N-hexanoyl-l-homoserine lactone (C6-HSL) induced C. violaceum CV026 cultures at sub-inhibitory concentrations .

HY-N1783

(24E)-3,4-Secocucurbita-4,24-diene-3,26,29-trioic acid	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Phosphatase
(24E)-3,4-Secocucurbita-4,24-diene-3,26,29-trioic acid is a potent PTP1B inhibitor, with an IC₅₀ of 0.4 μM. (24E)-3,4-Secocucurbita-4,24-diene-3,26,29-trioic acid exhibits potent PTP1B inhibitory activity without cytotoxicity .

HY-N11512

α-Glucosidase-IN-24	Structural Classification Polysaccharides Source classification Gentianaceae Plants Saccharides Swertia kouitchensis Franch.	Glycosidase
α-Glucosidase-IN-24 (Compound 13) is an α-Glucosidase inhibitor with an IC₅₀ of 451 μM. α-Glucosidase-IN-24 can be isolated from Swertia kouitchensis .

HY-133968R

24-Methylenecholesterol (Standard) Ostreasterol (Standard)	Structural Classification Microorganisms other families Animals Marine natural products Source classification Other marine organisms Plants Steroids	Acyltransferase Reactive Oxygen Species
24-Methylenecholesterol (Ostreasterol) (Standard) is the analytical standard of 24-Methylenecholesterol (HY-133968). This product is intended for research and analytical applications. 24-Methylenecholesterol (Ostreasterol) is a regulator targeting acyl-CoA cholesterol acyltransferase (ACAT) with anti-aging and neuroprotective effects. 24-Methylenecholesterol mimics the effects of nerve growth factor (NGF), can extend yeast lifespan through an anti-oxidative stress mechanism, and exhibits neuroprotective activity in PC12 cells. 24-Methylenecholesterol can reduce intracellular reactive oxygen species (ROS) and malondialdehyde (MDA) levels, activate anti-oxidative stress pathways (such as UTH1, SOD-related genes), and promote synaptic growth .

Cat. No.	Product Name	Chemical Structure

HY-W653849

2,4-Xylidine-d6
2,4-Xylidine-d₆ is a deuterated labeled 2,4-Xylidine .

HY-18572S

2,4-D-13C6
2,4-D- ¹³C₆ is the ¹³C-labeled 2,4-D. 2,4-D (2,4-Dichlorophenoxyacetic acid) is a selective systemic herbicide for the control of broad-leaved weeds. 2,4-D acts as a plant hormone, causing uncontrolled growth in the meristematic tissues. 2,4-D inhibits DNA and protein synthesis and thereby prevents normal plant growth and development .

HY-121779S

2,4’-DDE-d8
2,4'-DDE-d₈ is the deuterium labeled 2,4’-DDE .

HY-B1986S

*p,p'-DDE-d8*
p,p'-DDE-d₈ is the deuterium labeled p,p'-DDE . p,p'-DDE (4,4'-DDE), a major metabolite of persistent dichlorodiphenyltrichloroethane (DDT), is a potent androgen receptor antagonist, with an IC₅₀ of 5 μM and a K_i of 3.5 μM .

HY-13690S2

Mitotane-d8

Mitotane-d₈ is the deuterium labeled Mitotane . Mitotane (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions .

HY-13011S

Alectinib-d8
Alectinib-d₈ is the deuterium labeled Alectinib. Alectinib (CH5424802) is a potent, selective, and orally available ALK inhibitor with an IC₅₀ of 1.9 nM and a Kd value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC₅₀s of 1 nM and 3.5 nM, respectively . Alectinib demonstrates effective central nervous system (CNS) penetration .

HY-W280214S1

Nonylbenzene-d24
Nonylbenzene-d₂₄ is the deuterium labeled Nonylbenzene .

HY-W010420S

2,4-Difluoro-1-methylbenzene-d3
2,4-Difluoro-1-methylbenzene-d₃ is the deuterium labeled 2,4-Difluoro-1-methylbenzene .

HY-W009981S

*1-Bromo-2,4-difluorobenzene-d3*
1-Bromo-2,4-difluorobenzene-d₃ is the deuterium labeled 1-Bromo-2,4-difluorobenzene .

HY-17367S5

Atazanavir-d24

Atazanavir-d₂₄ (BMS-232632-d₂₄) is deuterium labeled Atazanavir. Atazanavir (BMS-232632) is a highly selective and orally active HIV-1 protease inhibitor . Atazanavir is a substrate and inhibitor of CYP3A4, and an inhibitor of P-glycoprotein (P-gp). Atazanavir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 3.49 μM. Atazanavir inhibits cardiac fibrosis, hyperlipidemia and induces malignant glioma death ^[8].

HY-W014223S1

2,4′-Dihydroxybenzophenone-d5
(2,4-Dihydroxyphenyl)(phenyl)methanone-d₅ is the deuterium labeled (2,4-Dihydroxyphenyl)(phenyl)methanone .

HY-W001955S

2-(4-Fluorophenyl)acetic acid-d2
2-(4-Fluorophenyl)acetic acid-d₂ is the deuterium labeled 2-(4-Fluorophenyl)acetic acid .

HY-10844S1

Pretomanid-d5
Pretomanid-d₅ is deuterated labeled Pretomanid (HY-10844). Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.

HY-W014779S

Dodecane-1,12-diol-d24
Dodecane-1,12-diol-d₂₄ is the deuterium labeled Dodecane-1,12-diol .

HY-W014223S

2,4-Dihydroxybenzophenone-13C6
2,4-Dihydroxybenzophenone- ¹³C₆ (Ultraviolet absorber UV-0- ¹³C₆) is the ¹³C- and deuterium labeled (2,4-Dihydroxyphenyl)(phenyl)methanone .

HY-17037S1

Pirenzepine-d8 dihydrochloride

Pirenzepine-d₈ (LS 519-d₈; Pirenzepin-d₈) dihydrochloride is a deuterium labeled Pirenzepine (dihydrochloride) (HY-17037). Pirenzepine (LS 519) dihydrochloride is a selective M1 mAChR (muscarinic acetylcholine receptor) antagonist. Pirenzepine dihydrochloride reduces gastric acid secretion and reduces muscle spasm, can be used in peptic ulcers research. Pirenzepine dihydrochloride shows anti-proliferative activity to cancer cells .

HY-G0021S

N-Desmethylclozapine-d8

N-Desmethylclozapine-d₈ is the deuterium labeled N-Desmethylclozapine. N-Desmethylclozapine is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine is a potent, allosteric and partial M1 receptors agonist (EC₅₀=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine is also a δ-opioid agonist .

HY-G0021S1

N-Desmethylclozapine-d8 hydrochloride

N-Desmethylclozapine-d₈ (hydrochloride) is the deuterium labeled N-Desmethylclozapine hydrochloride. N-Desmethylclozapine hydrochloride is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine hydrochloride is a potent, allosteric and partial M1 receptors agonist (EC₅₀=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine hydrochloride is also a δ-opioid agonist .

HY-B0615AS

Moricizine-d8(Hydrochloride)
Moricizine-d₈ (Hydrochloride) is the deuterium labeled Moricizine Hydrochloride (HY-B0615A). Moricizine Hydrochloride is an orally active Class I antiarrhythmic agent. Moricizine Hydrochloride decreases the maximum rate of phase 0 depolarization; increases rates of phase 2 and 3 repolarization, decreases action potential duration, and decreases effective refractory period .

HY-B0454AS

*Miconazole-d5 nitrate (2,4-Dichlorobenzyloxy-d5)*
Miconazole-d₅ (nitrate) (2,4-Dichlorobenzyloxy-d₅) is the deuterium labeled Miconazole nitrate. Miconazole nitrate (R18134 nitrate) is an imidazole antifungal agent. Miconazole nitrate also has antibacterial effects .

HY-50878S1

Crizotinib-d8

Crizotinib-d₈ (PF-02341066-d₈) is deuterium labeled Crizotinib. Crizotinib (PF-02341066) is an orally bioavailable, ATP-competitive ALK and c-Met inhibitor with IC₅₀s of 20 and 8 nM, respectively. Crizotinib inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC₅₀s of 24 and 11 nM in cell-based assays, respectively. Crizotinib is also a ROS1 inhibitor. Crizotinib has effective tumor growth inhibition .

HY-50896S3

Erlotinib-d8

Erlotinib-d₈ (CP-358774-d₈) is deuterium labeled Erlotinib. Erlotinib (CP-358774) is a directly acting EGFR tyrosine kinase inhibitor, with an IC₅₀ of 2 nM for human EGFR. Erlotinib reduces EGFR autophosphorylation in intact tumor cells with an IC₅₀ of 20 nM. Erlotinib is used for the treatment of non-small cell lung cancer . Erlotinib is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-15531S

Venetoclax-d8
Venetoclax-d₈ is deuterium labeled Venetoclax. Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a K_i of less than 0.01 nM. Venetoclax induces autophagy .

HY-14740S

Elvitegravir-d8
Elvitegravir-d₈ is deuterium labeled Elvitegravir. Elvitegravir (GS-9137; JTK-303; D06677) is an HIV integrase inhibitor for HIV-1IIIB, HIV-2EHO and HIV-2ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM, respectively.

HY-17037S

Pirenzepine-d8
Pirenzepine-d₈ is the deuterium labeled Pirenzepine dihydrochloride. Pirenzepine dihydrochloride (LS519) is a selective M1 muscarinic receptor antagonist.

HY-10227S

Bortezomib-d8
Bortezomib-d₈ is the deuterium labeled Bortezomib. Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is the first proteasome inhibitor anticancer agent. Anti-cancer activity .

HY-10570S2

Nevirapine-d8
Nevirapine-d₈ (BI-RG 587-d₈) is deuterium labeled Nevirapine. Nevirapine is a non-nucleoside inhibitor of HIV-1 reverse transcriptase used to treat and prevent HIV/AIDS; with a K_i of 270 μM .

HY-13463BS

Avatrombopag-d8 hydrochloride

Avatrombopag-d₈ (hydrochloride) is deuterium labeled Avatrombopag (hydrochloride). Avatrombopag (AKR-501) hydrochloride is an orally active, nonpeptide thrombopoietin (TPO) receptor agonist (EC₅₀=3.3 nM). Avatrombopag hydrochloride mimics the biological activities of TPO. Avatrombopag hydrochloride increases platelet production by activating the intracellular signaling system, and promotes production of platelets and megakaryocytes from hemopoietic precursor cells. Avatrombopag hydrochloride is a substrate of cytochrome P450 (CYP) 2C9 and CYP3A .

HY-B0966S

Dioxybenzone-d3

Dioxybenzone-d₃ is deuterium labeled Dioxybenzone. Dioxybenzone (Benzophenone-8; UV-24) is an organic compound used to block UVB and short-wave UVA (ultraviolet) radiation. Dioxybenzone has orally activity. Dioxybenzone exhibits estrogenic disrupting effect. Dioxybenzone up-regulates inflammatory cytokines. Dioxybenzone can be used for cancer, reproductive system disease and inflammatory disease study .

HY-15581S

MMAD-d8
MMAD-d₈D is a deuterated form of MMAD, which is a microtubule disrupting agent.

HY-Y1309S

1-Naphthol-d8
1-Naphthol-d₈ is the deuterium labeled 1-Naphthol . 1-naphthol is an excited state proton transfer (ESPT) fluorescent molecular probe .

HY-N0623S5

L-Tryptophan-d8
L-Tryptophan-d₈ is the deuterium labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3 .

HY-B0272S1

Rifampicin-d8
Rifampicin-d8 (Rifampin-d8) is the deuterium labeled Rifampicin. Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities.

HY-N0378S

D-Mannitol-d8
D-Mannitol-d₈ is the deuterium labeled D-Mannitol. D-Mannitol is an osmotic diuretic agent and a weak renal vasodilator.

HY-N0007S

Bisdemethoxycurcumin-d8

Bisdemethoxycurcumin-d₈ (Curcumin III-d₈) is the deuterium labeled Bisdemethoxycurcumin (HY-N0007A). Bisdemethoxycucurmin (Curcumin III) is a curcuminoid compound and an inhibitor of P-glycoprotein and ferroptosis. Bisdemethoxycucurmin exhibits multiple activities such as anti-oxidation, anti-inflammation and anti-tumor. Bisdemethoxycucurmin can be used for the research of tumors and inflammatory diseases .

HY-B0104S2

Glimepiride-d8
Glimepiride-d₈ (Glimperide-d₈; HOE-490-d₈) is deuterium-labeled Glimepiride (HY-B0104) .

HY-13502AS

Mitoxantrone-d8 dihydrochloride

Mitoxantrone-d₈ dihydrochloride is deuterated labeled Mitoxantrone dihydrochloride (HY-13502A). Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC₅₀ of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity . Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC₅₀s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .

HY-B0246S2

Carbamazepine-d8
Carbamazepine-d₈ is the deuterium labeled Carbamazepine. Carbamazepine, a sodium channel blocker, is an anticonvulsant agent, with an IC₅₀ of 131 μM .

HY-13502AS1

Mitoxantrone-d8 hydrochloride

Mitoxantrone-d₈ (hydrochloride) (Mitozantrone-d₈ (hydrochloride)) is deuterium labeled Mitoxantrone (dihydrochloride). Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC₅₀ of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity . Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC₅₀s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .

HY-90001S2

Ritonavir-d8
Ritonavir-d₈ is deuterated labeled Ritonavir (HY-90001). Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 1.61 μM.

HY-13502S

Mitoxantrone-d8
Mitoxantrone-d₈ (mitozantrone-d₈) is the deuterium labeled Mitoxantrone. Mitoxantrone is a topoisomerase II inhibitor and also inhibits protein kinase C (PKC) activity with an IC₅₀ of 8.5 μM .

HY-B1970S

o,p'-DDT-d8
o,p'-DDT-d₈ is the deuterium labeled o,p'-DDT .

HY-B1955S

4',4-Dibromobiphenyl-d8
4',4-Dibromobiphenyl-d₈ is the deuterium labeled 4',4-Dibromobiphenyl[1].

HY-34444S

1,1-Dioxothiolan-d8
1,1-Dioxothiolan-d₈ is the deuterium labeled 1,1-Dioxothiolan .

HY-10617AS

Rucaparib-d8
Rucaparib-d₈ (AG014699-d₈ ) is deuterium labeled Rucaparib. Rucaparib (AG014699) is an orally active, potent inhibitor of PARP proteins (PARP-1, PARP-2 and PARP-3) with a K_i of 1.4 nM for PARP1. Rucaparib is a modest hexose-6-phosphate dehydrogenase (H6PD) inhibitor. Rucaparib has the potential for castration-resistant prostate cancer (CRPC) research .

HY-W739793

Pantoprazole-d8 sodium

Pantoprazole-d₈ (BY1023-d₈) sodium is a deuterium labeled Pantoprazole (HY-17507). Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole, a substituted benzimidazole, is a potent H ⁺/K ⁺-ATPase inhibitor with an IC₅₀ of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .

HY-107434S

Molindone-d8
Molindone-d₈ is the deuterium labeled Molindone. Molindone hydrochloride (EN-1733A) is a therapeutic antipsychotic, used in the treatment of schizophrenia, works by blocking the effects of dopamine in the brain, leading to diminished psychoses .

HY-B1895S

Levodropropizine-d8
Levodropropizine-d₈ is deuterium labeled Levodropropizine. Levodropropizine (DF-526) is a histamine receptor inhibitor, Levodropropizine is an effective and very well tolerated peripheral antitussive agent.

HY-17507S2

Pantoprazole-d8

Pantoprazole-d₈ (BY1023-d₈) is deuterium labeled Pantoprazole. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole, a substituted benzimidazole, is a potent H ⁺/K ⁺-ATPase inhibitor with an IC₅₀ of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .

HY-13593S

Chlorambucil-d8
Chlorambucil-d₈ is the deuterium labeled Chlorambucil. Chlorambucil (CB-1348), an orally active antineoplastic agent, is a bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease .

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