Betavulgarin

Cat. No.: HY-N15201: Data Sheet Handling Instructions
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Betavulgarin is an anticancer agent. Betavulgarin can be isolated from Sugar Beet (Beta vulgaris). Betavulgarin suppresses the proliferation, migration, colony formation, and mammosphere formation of breast cancer cells, and reduces the size of the CD44⁺/CD24⁻ subpopulation and the expression of the self-renewal- related genes C-Myc, Nanog and Oct4. Betavulgarin promotes BCSCs death through the regulation of Stat3/Sox2 signaling.

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Betavulgarin Chemical Structure

CAS No. : 51068-94-1

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Description

IC₅₀ & Target^[1]

p-STAT3

In Vitro

Betavulgarin (50-500 μM, 24 h) significantly suppresses the proliferation, migration, colony formation, and mammosphere formation of MDA-MB-231 cells, MCF-7 cells^[1].
Betavulgarin (200 μM, 24 h) reduces the size of the CD44⁺/CD24⁻ subpopulation with the cell fraction from 90.4% to 57.2% in MDA-MB-231 cells^[1].
Betavulgarin (200 μM, 48 h) inhibits the translocation of Stat3 and decreases the total protein level and nuclear protein level of p-Stat3 as well as the mRNA and protein levels of SOX2 in MDA-MB-231-derived mammospheres^[1].
Betavulgarin (200 μM, 48 h) significantly inhibits the DNA-binding capacity of Stat3 in MDA-MB-231-derived mammosphere^[1].
Betavulgarin (24-72 h) reduces the mRNA expression of the self-renewal- related genes, C-Myc, Nanog, and Oct4 in BCSCs-derived mammospheres, and inhibits mammosphere growth^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	MDA-MB-231 cells, MCF-7 cells
Concentration:	50, 100, 200, 300, 400, 500 μM
Incubation Time:	24 h
Result:	Suppressed the proliferation of MDA-MB-231 and MCF-7 cells at ≥ 100 µM and 50 µM, respectively.

Cell Migration Assay ^[1]

Cell Line:	MDA-MB-231 cells, MCF-7 cells
Concentration:	100 μM
Incubation Time:	24 h
Result:	Inhibited migration of MDA-MB-231 and MCF-7 cells.

Western Blot Analysis^[1]

Cell Line:	MDA-MB-231 cells, MCF-7 cells
Concentration:	200 μM
Incubation Time:	48 h
Result:	Inhibited the translocation of Stat3, and significantly decreased the total protein levels and nuclear protein level of Stat3 and p-Stat3, as well as the protein levels of SOX2 in MDA-MB-231-derived mammospheres.

Immunofluorescence^[1]

Cell Line:	MDA-MB-231 cells, MCF-7 cells
Concentration:	200 μM
Incubation Time:	48 h
Result:	Reduced the level of nuclear pStat3 in MDA-MB-231 cells.

Real Time qPCR^[1]

Cell Line:	MDA-MB-231 cells
Concentration:	200 μM
Incubation Time:	48 h
Result:	Reduced the mRNA level of SOX2 in MDA-MB-231-derived mammospheres.

Molecular Weight

312.27

Formula

C₁₇H₁₂O₆

CAS No.

51068-94-1

SMILES

O=C1C(C2=C(O)C=CC=C2)=COC3=C1C(OC)=C4OCOC4=C3

Structure Classification

Others

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Liu R, et al. Betavulgarin Isolated from Sugar Beet (Beta vulgaris) Suppresses Breast Cancer Stem Cells through Stat3 Signaling. Molecules. 2020 Jun 30; 25(13):2999. [Content Brief]

Betavulgarin Related Classifications

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Betavulgarin51068-94-1STATInhibitorsAnticancerBCSCsMammospheresStat3SOX2MDA-MB-231MCF-7 cellsInhibitorinhibitorinhibit

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