2. Membrane Transporter/Ion Channel
  3. Chloride Channel
  4. Allobetulone

Allobetulone (N066-0059) is a TMEM16A inhibitor (IC50: 0.24 µM). Allobetulone (N066-0059) can be used in anti-cancer research.

For research use only. We do not sell to patients.

Allobetulone

Allobetulone Chemical Structure

CAS No. : 28282-22-6

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Allobetulone Related Antibodies

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Description

Allobetulone (N066-0059) is a TMEM16A inhibitor (IC50: 0.24 µM). Allobetulone (N066-0059) can be used in anti-cancer research[1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
> 50 μM
Compound: 7a
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
[PMID: 36174412]
BJ IC50
> 50 μM
Compound: 7a
Cytotoxicity against human BJ cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
Cytotoxicity against human BJ cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
[PMID: 36174412]
BXPC-3 GI50
> 10 μg/mL
Compound: 18
Cytotoxicity against human BxPC3 cells after 48 hrs by SRB assay
Cytotoxicity against human BxPC3 cells after 48 hrs by SRB assay
[PMID: 24694263]
CCRF-CEM IC50
> 50 μM
Compound: 3b
Cytotoxicity against human CCRF-CEM cells after 72 hrs by MTS assay
Cytotoxicity against human CCRF-CEM cells after 72 hrs by MTS assay
[PMID: 27236068]
CCRF-CEM IC50
> 50 μM
Compound: 7a
Cytotoxicity against human CCRF-CEM cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
Cytotoxicity against human CCRF-CEM cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
[PMID: 36174412]
CEM-DNR IC50
> 50 μM
Compound: 7a
Cytotoxicity against human CEM-DNR cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
Cytotoxicity against human CEM-DNR cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
[PMID: 36174412]
DU-145 GI50
> 10 μg/mL
Compound: 18
Cytotoxicity against human DU145 cells after 48 hrs by SRB assay
Cytotoxicity against human DU145 cells after 48 hrs by SRB assay
[PMID: 24694263]
HCT-116 IC50
> 50 μM
Compound: 7a
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
[PMID: 36174412]
K562 IC50
> 50 μM
Compound: 7a
Cytotoxicity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
Cytotoxicity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
[PMID: 36174412]
KM-20L2 GI50
> 10 μg/mL
Compound: 18
Cytotoxicity against human KM20L2 cells after 48 hrs by SRB assay
Cytotoxicity against human KM20L2 cells after 48 hrs by SRB assay
[PMID: 24694263]
MCF7 GI50
> 10 μg/mL
Compound: 18
Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
[PMID: 24694263]
MRC5 IC50
> 50 μM
Compound: 7a
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
[PMID: 36174412]
NCI-H460 GI50
> 10 μg/mL
Compound: 18
Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay
Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay
[PMID: 24694263]
SF-268 GI50
> 10 μg/mL
Compound: 18
Cytotoxicity against human SF268 cells after 48 hrs by SRB assay
Cytotoxicity against human SF268 cells after 48 hrs by SRB assay
[PMID: 24694263]
U2OS IC50
> 50 μM
Compound: 7a
Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
[PMID: 36174412]
Molecular Weight

440.70

Formula

C30H48O2
CAS No.
SMILES

C[C@]12[C@@](CC[C@@]3([H])[C@]2(CC[C@]4([H])[C@@]3(CCC(C4(C)C)=O)C)C)([H])[C@]5([H])[C@@]6(CO[C@@]5([H])C(C)(CC6)C)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Allobetulone Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Allobetulone28282-22-6N066-0059Chloride ChannelCl− Channelsanti-cancerCalu-3 cellsInhibitorinhibitorinhibit

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Allobetulone
Cat. No.:
HY-176453
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