Mal-PEG24-NHS ester

Name: Mal-PEG24-NHS ester
Brand: MedChemExpress
SKU: HY-135819
Rating: 4.5 (1 reviews)

Cat. No.: HY-135819 Purity: 95.0%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Mal-PEG24-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Mal-PEG24-NHS ester Chemical Structure

CAS No. : 2226733-37-3

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Mal-PEG24-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1394.55

Formula

C₆₂H₁₁₁N₃O₃₁

CAS No.

2226733-37-3

Appearance

Oil

Color

Colorless to light yellow

SMILES

O=C(ON1C(=O)CCC1=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCN2C(=O)C=CC2=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : ≥ 100 mg/mL (71.71 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.7171 mL	3.5854 mL	7.1708 mL
5 mM	0.1434 mL	0.7171 mL	1.4342 mL
10 mM	0.0717 mL	0.3585 mL	0.7171 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 95.0%

Select Batch:

Data Sheet (271 KB) SDS (252 KB)

COA (249 KB) HNMR (245 KB) MS (89 KB)

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	0.7171 mL	3.5854 mL	7.1708 mL	17.9269 mL
	5 mM	0.1434 mL	0.7171 mL	1.4342 mL	3.5854 mL
	10 mM	0.0717 mL	0.3585 mL	0.7171 mL	1.7927 mL
	15 mM	0.0478 mL	0.2390 mL	0.4781 mL	1.1951 mL
	20 mM	0.0359 mL	0.1793 mL	0.3585 mL	0.8963 mL
	25 mM	0.0287 mL	0.1434 mL	0.2868 mL	0.7171 mL
	30 mM	0.0239 mL	0.1195 mL	0.2390 mL	0.5976 mL
	40 mM	0.0179 mL	0.0896 mL	0.1793 mL	0.4482 mL
	50 mM	0.0143 mL	0.0717 mL	0.1434 mL	0.3585 mL
	60 mM	0.0120 mL	0.0598 mL	0.1195 mL	0.2988 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.