Egr-1 Antibody (YA4823)

Egr-1 Antibody (YA4823) is a mouse-derived and non-conjugated monoclonal antibody, targeting to Egr-1. It can be applicated for WB, ELISA assays, in the background of human.

EGR1 is a transcriptional regulator that recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (EGR-site) in the promoter region of target genes (By similarity). It binds double-stranded target DNA regardless of cytosine methylation status. EGR1 regulates the transcription of numerous target genes, playing a key role in cellular responses to growth factors, DNA damage, and ischemia, as well as in controlling cell survival, proliferation, and death. It activates the expression of p53/TP53 and TGFB1, contributing to tumor prevention. EGR1 is essential for normal mitosis progression and hepatocyte proliferation after partial hepatectomy. It mediates responses to ischemia and hypoxia by regulating the expression of proteins like IL1B and CXCL2, which are involved in inflammation and post-ischemic tissue damage (By similarity). Additionally, EGR1 modulates the amplitude of clock gene expression rhythms (BMAL1, PER2, NR1D1) in the liver via PER1 activation and regulates the rhythmic expression of core-clock gene BMAL1 in the suprachiasmatic nucleus (SCN) (By similarity).

P18146

Predicted band size: 78 kDa;

affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

WB: 1:500-1:2000; ELISA: 1:10000

WB, ELISA

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant fragment of human Egr-1 (aa282-433) expressed in E. Coli.