2. Vitamin D Related/Nuclear Receptor Immunology/Inflammation Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. VD/VDR Aryl Hydrocarbon Receptor LXR PPAR
  4. 25-Hydroxytachysterol3

25-Hydroxytachysterol3 is the metabolite of Vitamin D3 (HY-15398). 25-Hydroxytachysterol3 inhibits the proliferation of epidermal keratinocytes and dermal fibroblasts, stimulates the expression of differentiation- and antioxidant-related genes in keratinocytes. 25-Hydroxytachysterol3 activates vitamin D receptor (VDR) and aryl hydrocarbon receptor (AhR), liver X receptor α/β (LXR α/β) and peroxisome proliferator-activated receptor γ (PPARγ), stimulates the expression of CYP24A1.

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25-Hydroxytachysterol3 Chemical Structure

25-Hydroxytachysterol3 Chemical Structure

CAS No. : 39932-44-0

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25-Hydroxytachysterol3 Related Antibodies

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Description

25-Hydroxytachysterol3 is the metabolite of Vitamin D3 (HY-15398). 25-Hydroxytachysterol3 inhibits the proliferation of epidermal keratinocytes and dermal fibroblasts, stimulates the expression of differentiation- and antioxidant-related genes in keratinocytes. 25-Hydroxytachysterol3 activates vitamin D receptor (VDR) and aryl hydrocarbon receptor (AhR), liver X receptor α/β (LXR α/β) and peroxisome proliferator-activated receptor γ (PPARγ), stimulates the expression of CYP24A1[1].

IC50 & Target

PPARγ

 

In Vitro

25-Hydroxytachysterol3 (25(OH)T3) (0.1-100 μM; 24-48 h) inhibits the proliferation of epidermal keratinocytes and dermal fibroblasts[1].
25-Hydroxytachysterol3 (0.1-100 μM; 24 h) stimulates the expression of genes involved in keratinocyte differentiation and antioxidative pathways[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

25-Hydroxytachysterol3 Related Antibodies

Cell Viability Assay[1]

Cell Line: Primary human epidermal keratinocytes or dermal fibroblasts.
Concentration: 0.1 μM, 1 μM, 10 μM, 100 μM
Incubation Time: 24 h or 48 h
Result: Inhibited the proliferation of epidermal keratinocytes and dermal fibroblasts.

RT-PCR[1]

Cell Line: Primary human epidermal keratinocytes or dermal fibroblasts.
Concentration: 0.1 μM, 1 μM, 10 μM, 100 μM
Incubation Time: 24 h
Result: Showed stimulation of the expression of genes involved in keratinocyte differentiation (KRT1, KRT10, FLG, IVL, LOR, TGM1) and antioxidative pathways (CAT, SOD1, SOD2).
Molecular Weight

400.64

Formula

C27H44O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCCC(C)(O)C)([H])C(/C=C/C3=C(CC[C@@H](C3)O)C)=CCC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Purity & Documentation
References
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25-Hydroxytachysterol3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

25-Hydroxytachysterol339932-44-0VD/VDRAryl Hydrocarbon ReceptorLXRPPARVitamin DVitamin D receptorAhRLiver X receptorPeroxisome proliferator-activated receptorsVitamin D3tachysterolanti-oxidantskinInhibitorinhibitorinhibit

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