2. Epigenetics Metabolic Enzyme/Protease
  3. Epigenetic Reader Domain E1/E2/E3 Enzyme
  4. LO-3-62

LO-3-62 is a PROTAC-like SMARCA2/4 degrader with a truncated fumaramide handle. LO-3-62 degrades SMARCA2/4 in cells.

For research use only. We do not sell to patients.

LO-3-62 Chemical Structure

LO-3-62 Chemical Structure

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LO-3-62 Related Antibodies

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Description

LO-3-62 is a PROTAC-like SMARCA2/4 degrader with a truncated fumaramide handle. LO-3-62 degrades SMARCA2/4 in cells[1].

In Vitro

LO-3-62 (1-10 μM, 24 h) degrades SMARCA2/4 in MV-4-11 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LO-3-62 Related Antibodies

Western Blot Analysis[1]

Cell Line: MV-4-11 cells
Concentration: 1, 10 μM
Incubation Time: 24 h
Result: Degraded SMARCA2/4 in MV-4-11 cells.
Molecular Weight

479.92

Formula

C23H22ClN7O3
SMILES

O=C(NC1=CC(Cl)=CN=C1)/C=C/C(N2CCN(C3=CC(C4=CC=CC=C4O)=NN=C3N)CC2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LO-3-62 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LO-3-62Epigenetic Reader DomainE1/E2/E3 EnzymeE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligaseDCAF16SMARCA2/4MV-4-11 cellsInhibitorinhibitorinhibit

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LO-3-62
Cat. No.:
HY-175186
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