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  4. ddATP trisodium

ddATP trisodium  (Synonyms: 2',3'-Dideoxyadenosine 5'-triphosphate trisodium)

Cat. No.: HY-128036B Purity: 99.93%
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ddATP (2',3'-Dideoxyadenosine 5'-triphosphate) trisodium, an active metabolite of 2',3'-dideoxyinosine, is a chain-elongating inhibitor of DNA polymerase. ddATP trisodium can be used for Sanger method for DNA sequencing and research of virus infection.

For research use only. We do not sell to patients.

ddATP trisodium Chemical Structure

ddATP trisodium Chemical Structure

CAS No. : 72029-21-1

Size Price Stock Quantity
Solvent
27 mg (100 mM * 0.5 mL in Water) In-stock
Solvent
54 mg (100 mM * 1 mL in Water) In-stock

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Based on 1 publication(s) in Google Scholar

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ddATP trisodium Related Antibodies

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1 Publications Citing Use of MCE ddATP trisodium

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Description

ddATP (2',3'-Dideoxyadenosine 5'-triphosphate) trisodium, an active metabolite of 2',3'-dideoxyinosine, is a chain-elongating inhibitor of DNA polymerase. ddATP trisodium can be used for Sanger method for DNA sequencing and research of virus infection[1][2][4].

In Vitro

ddATP (0.05-50 μM, 30 min) trisodium inhibits adenovirus DNA synthesis in isolated nuclei from adenovirus-infected KB cells[1].
ddATP (100 μM, 5 h) trisodium reduces the number of γH2A.X foci in the DSB (DNA double-strand breaks) oocytes[3].
ddATP trisodium inhibits HIV replication by inhibiting HIV reverse transcriptase[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ddATP trisodium Related Antibodies

Immunofluorescence[3]

Cell Line: DSB oocytes
Concentration: 100 μM
Incubation Time: 5 h
Result: Suppressed the mtDNA replication without fully suppressed the nuclear DNA replication.
Molecular Weight

541.13

Formula

C10H13N5Na3O11P3
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

NC1=NC=NC2=C1N=CN2[C@H]3CC[C@H](O3)COP(OP(OP(O)(O[Na])=O)(O[Na])=O)(O[Na])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years
Solvent & Solubility
In Vitro: 

H2O : 25 mg/mL (46.20 mM; Need ultrasonic)

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.8480 mL 9.2399 mL 18.4798 mL 46.1996 mL
5 mM 0.3696 mL 1.8480 mL 3.6960 mL 9.2399 mL
10 mM 0.1848 mL 0.9240 mL 1.8480 mL 4.6200 mL
15 mM 0.1232 mL 0.6160 mL 1.2320 mL 3.0800 mL
20 mM 0.0924 mL 0.4620 mL 0.9240 mL 2.3100 mL
25 mM 0.0739 mL 0.3696 mL 0.7392 mL 1.8480 mL
30 mM 0.0616 mL 0.3080 mL 0.6160 mL 1.5400 mL
40 mM 0.0462 mL 0.2310 mL 0.4620 mL 1.1550 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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ddATP trisodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ddATP trisodium72029-21-12',3'-Dideoxyadenosine 5'-triphosphate trisodiumDNA/RNA SynthesisHIVHuman immunodeficiency virusAdenovirusddIPBMCDSBoocytesreplicationinfectionInhibitorinhibitorinhibit

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