2. Recombinant Proteins
  3. Immune Checkpoint Proteins
  4. Inhibitory Checkpoint Molecules
  5. VISTA
  6. VISTA/B7-H5 Protein, Human (Biotinylated, HEK293, Fc-Avi)

VISTA/B7-H5 Protein, Human (Biotinylated, HEK293, Fc-Avi)

Cat. No.: HY-P78929
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VISTA/B7-H5 protein, an immunoregulatory receptor, inhibits T-cell response and may regulate embryonic stem cell differentiation by inhibiting BMP4 signaling. It also stimulates MMP14-mediated MMP2 activation, suggesting a role in matrix metalloproteinase processes. These roles highlight the significance of VISTA/B7-H5 in immune regulation, embryonic development, and extracellular matrix dynamics. VISTA/B7-H5 Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived VISTA/B7-H5 protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag. The total length of VISTA/B7-H5 Protein, Human (Biotinylated, HEK293, Fc-Avi) is 162 a.a., with molecular weight of 55-66 kDa.

For research use only. We do not sell to patients.

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Description

VISTA/B7-H5 protein, an immunoregulatory receptor, inhibits T-cell response and may regulate embryonic stem cell differentiation by inhibiting BMP4 signaling. It also stimulates MMP14-mediated MMP2 activation, suggesting a role in matrix metalloproteinase processes. These roles highlight the significance of VISTA/B7-H5 in immune regulation, embryonic development, and extracellular matrix dynamics. VISTA/B7-H5 Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived VISTA/B7-H5 protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag. The total length of VISTA/B7-H5 Protein, Human (Biotinylated, HEK293, Fc-Avi) is 162 a.a., with molecular weight of 55-66 kDa.
Background

VISTA/B7-H5 protein, functioning as an immunoregulatory receptor, plays a pivotal role in inhibiting the T-cell response, as established in various studies. Additionally, it may contribute to the differentiation of embryonic stem cells by inhibiting BMP4 signaling, showcasing its potential role in developmental processes. Moreover, VISTA/B7-H5 has been implicated in stimulating MMP14-mediated MMP2 activation, suggesting a regulatory function in matrix metalloproteinase-mediated processes. This multifaceted role underscores the significance of VISTA/B7-H5 in immune regulation, embryonic development, and extracellular matrix dynamics, revealing its potential impact across diverse biological contexts.
Species

Human
Source

HEK293
Tag

C-Avi;C-hFc
Accession

Q9H7M9 (F33-A194)
Gene ID
Synonyms
B7-H5; SISP1; Gi24; VISTA
Molecular Weight

55-66 kDa
Purity

Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

VISTA/B7-H5 Protein, Human (Biotinylated, HEK293, Fc-Avi) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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