2. PI3K/Akt/mTOR Stem Cell/Wnt
  3. GSK-3
  4. CDKL5/GSK3-IN-1

CDKL5/GSK3-IN-1 (Compound 2) is a potent and selectivity chemical probe for CDKL5/GSK3.CDKL5/GSK3-IN-1 has potent inhibition of CDKL5 and GSK3α/β, with IC50 values of 4.6, 24 and 9.5 nM for CDKL5, GSK3β and GSK3α, respectively, in the NanoBRET assay. CDKL5/GSK3-IN-1 can be used for the research of CNS diseases.

For research use only. We do not sell to patients.

CDKL5/GSK3-IN-1 Chemical Structure

CDKL5/GSK3-IN-1 Chemical Structure

CAS No. : 844442-32-6

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Based on 1 publication(s) in Google Scholar

CDKL5/GSK3-IN-1 Related Antibodies

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Description

CDKL5/GSK3-IN-1 (Compound 2) is a potent and selectivity chemical probe for CDKL5/GSK3.CDKL5/GSK3-IN-1 has potent inhibition of CDKL5 and GSK3α/β, with IC50 values of 4.6, 24 and 9.5 nM for CDKL5, GSK3β and GSK3α, respectively, in the NanoBRET assay. CDKL5/GSK3-IN-1 can be used for the research of CNS diseases[1].

Molecular Weight

349.34

Formula

C16H17F2N5O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC(F)=CC(F)=C1)NC2=CNN=C2C(NC3CCNCC3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (57.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8625 mL 14.3127 mL 28.6254 mL
5 mM 0.5725 mL 2.8625 mL 5.7251 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8625 mL 14.3127 mL 28.6254 mL 71.5635 mL
5 mM 0.5725 mL 2.8625 mL 5.7251 mL 14.3127 mL
10 mM 0.2863 mL 1.4313 mL 2.8625 mL 7.1564 mL
15 mM 0.1908 mL 0.9542 mL 1.9084 mL 4.7709 mL
20 mM 0.1431 mL 0.7156 mL 1.4313 mL 3.5782 mL
25 mM 0.1145 mL 0.5725 mL 1.1450 mL 2.8625 mL
30 mM 0.0954 mL 0.4771 mL 0.9542 mL 2.3855 mL
40 mM 0.0716 mL 0.3578 mL 0.7156 mL 1.7891 mL
50 mM 0.0573 mL 0.2863 mL 0.5725 mL 1.4313 mL
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CDKL5/GSK3-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDKL5/GSK3-IN-1844442-32-6GSK-3Glycogen synthase kinase-3Glycogen synthase kinase 3GSK3αGSK3βCNS diseasesInhibitorinhibitorinhibit

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