4-Thiouracil

Cat. No.: HY-W010417 Purity: 98.17%: Data Sheet
SDS

COA
Handling Instructions
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4-Thiouracil is a thionucleobase with cytostatic properties. 4-Thiouracil can be used as biological photoprobes to detect RNA structures and nucleic acid-nucleic acid contacts. 4-Thiouracil can also act as a strong ultraviolet A (UVA) photosensitizer, providing a source of the reactive oxygen species of O₂. 4-Thiouracil is promising for research of photocross linking, photodamage, as well as photodynamic therapy.

For research use only. We do not sell to patients.

4-Thiouracil Chemical Structure

CAS No. : 591-28-6

Size	Stock	Quantity
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100 mg	In-stock	Estimated Time of Arrival: December 31
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500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	In-stock	Estimated Time of Arrival: December 31
10 g	In-stock	Estimated Time of Arrival: December 31
25 g	In-stock	Estimated Time of Arrival: December 31
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Description

Molecular Weight

128.15

Formula

C₄H₄N₂OS

CAS No.

591-28-6

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N1)NC=CC1=S

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (390.17 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.8034 mL	39.0168 mL	78.0336 mL
5 mM	1.5607 mL	7.8034 mL	15.6067 mL
10 mM	0.7803 mL	3.9017 mL	7.8034 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.98%

Select Batch:

Data Sheet (271 KB) SDS (393 KB)

COA (250 KB) HNMR (129 KB) RP-HPLC (242 KB)

Handling Instructions (2659 KB)

References

[1]. Zou X, et al. Photophysical and photochemical properties of 4-thiouracil: time-resolved IR spectroscopy and DFT studies. J Phys Chem B. 2014 Jun 5;118(22):5864-72. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	7.8034 mL	39.0168 mL	78.0336 mL	195.0839 mL
	5 mM	1.5607 mL	7.8034 mL	15.6067 mL	39.0168 mL
	10 mM	0.7803 mL	3.9017 mL	7.8034 mL	19.5084 mL
	15 mM	0.5202 mL	2.6011 mL	5.2022 mL	13.0056 mL
	20 mM	0.3902 mL	1.9508 mL	3.9017 mL	9.7542 mL
	25 mM	0.3121 mL	1.5607 mL	3.1213 mL	7.8034 mL
	30 mM	0.2601 mL	1.3006 mL	2.6011 mL	6.5028 mL
	40 mM	0.1951 mL	0.9754 mL	1.9508 mL	4.8771 mL
	50 mM	0.1561 mL	0.7803 mL	1.5607 mL	3.9017 mL
	60 mM	0.1301 mL	0.6503 mL	1.3006 mL	3.2514 mL
	80 mM	0.0975 mL	0.4877 mL	0.9754 mL	2.4385 mL
	100 mM	0.0780 mL	0.3902 mL	0.7803 mL	1.9508 mL

4-Thiouracil Related Classifications

Others

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-Thiouracil591-28-6Reactive Oxygen SpeciesThionucleobasecytostaticRNA structuresnucleic acid-nucleic acid contactsUVA photosensitizerInhibitorinhibitorinhibit

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4-Thiouracil

4-Thiouracil Related Antibodies

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