CD151 Antibody (YA4047)

CD151 Antibody (YA4047) is a mouse-derived and non-conjugated IgG2a antibody, targeting to CD151. It can be applicated for IHC-P, FC, ELISA assays, in the background of human.

CD151 is a structural component of tetraspanin-enriched microdomains (TERMs), serving as platforms for receptor clustering and signaling. Through interactions with both integrin and non-integrin proteins, it participates in various cellular and molecular mechanisms, including cell-to-cell communication, wound healing, platelet aggregation, trafficking, cell motility, and angiogenesis. By associating with JAM-A/F11R and integrin ITGA3:ITGB1, CD151 facilitates the recruitment of signaling molecules such as RAC1, CDC42, and RhoGTPases, promoting epithelial cell polarization and actin cytoskeleton reorganization—critical steps in cell migration. It also regulates the glycosylation pattern of ITGA3:ITGB1 to modulate its activity and plays a vital role in maintaining the stability of central laminin-binding integrin ITGA6:ITGB4-containing adhesion complexes. Furthermore, CD151 is essential for the proper assembly of glomerular and tubular basement membranes in the kidney and enhances T-cell activation by modulating integrin signaling, leading to downstream activation of PTK2 and MAPK1/MAPK3. In microbial infections, CD151 contributes to human papillomavirus 16/HPV-16 endocytosis and facilitates human cytomegalovirus entry into host cells by influencing receptor binding, membrane fusion, or capsid release.

P48509 

Predicted band size: 28.3 kDa; Observed band size: 28 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human

IHC: 1/200-1/1000; FC: 1/200-1/400; ELISA: 1/10000

IHC-P, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG2a

Purified recombinant fragment of human CD151 (AA: extra 113-221) expressed in E. Coli.