2. Others Neuronal Signaling GPCR/G Protein Apoptosis Membrane Transporter/Ion Channel NF-κB PI3K/Akt/mTOR Immunology/Inflammation MAPK/ERK Pathway Stem Cell/Wnt
  3. Reference Standards Opioid Receptor Apoptosis Potassium Channel NF-κB Akt IRAK JNK Toll-like Receptor (TLR) ERK Calcium Channel
  4. Trimebutine maleate (Standard)

Trimebutine maleate (Standard) 

Cat. No.: HY-B0380AR Purity: ≥98%
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Trimebutine maleate (Standard) is the analytical standard of Trimebutine maleate (HY-B0380A). This product is intended for research and analytical applications. Trimebutine maleate is a multi-target inhibitor and opioid receptor agonist with antimuscarinic activity. Trimebutine maleate inhibits L-type Ca2+ channels and large-conductance calcium-activated potassium channels (BKCa channels), thereby inhibiting extracellular calcium influx and potassium ion efflux. Trimebutine maleate also targets Toll-like receptors, inhibits Toll-like receptor 2/4/7/8/9 signals, and inhibits LPS-induced IRAK1 activation, as well as ERK1/2, JNK and NF-κB activation, thereby exerting anti-inflammatory effects. Trimebutine maleate also induces tumor cell apoptosis by inhibiting the AKT/ERK pathway. Trimebutine maleate also inhibits excessive contraction of smooth muscle and can be used in the study of gastrointestinal disorders such as irritable bowel syndrome (IBS).

For research use only. We do not sell to patients.

Trimebutine maleate (Standard) Chemical Structure

Trimebutine maleate (Standard) Chemical Structure

CAS No. : 34140-59-5

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Description

Trimebutine maleate (Standard) is the analytical standard of Trimebutine maleate (HY-B0380A). This product is intended for research and analytical applications. Trimebutine maleate is a multi-target inhibitor and opioid receptor agonist with antimuscarinic activity. Trimebutine maleate inhibits L-type Ca2+ channels and large-conductance calcium-activated potassium channels (BKCa channels), thereby inhibiting extracellular calcium influx and potassium ion efflux. Trimebutine maleate also targets Toll-like receptors, inhibits Toll-like receptor 2/4/7/8/9 signals, and inhibits LPS-induced IRAK1 activation, as well as ERK1/2, JNK and NF-κB activation, thereby exerting anti-inflammatory effects. Trimebutine maleate also induces tumor cell apoptosis by inhibiting the AKT/ERK pathway. Trimebutine maleate also inhibits excessive contraction of smooth muscle and can be used in the study of gastrointestinal disorders such as irritable bowel syndrome (IBS).

Molecular Weight

503.54

Formula

C26H33NO9
CAS No.
SMILES

O=C(O)/C=C\C(O)=O.O=C(OCC(C1=CC=CC=C1)(N(C)C)CC)C2=CC(OC)=C(OC)C(OC)=C2
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Trimebutine maleate (Standard) Related Classifications

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Keywords:

Trimebutine maleate (Standard)34140-59-5Reference StandardsOpioid ReceptorApoptosisPotassium ChannelNF-κBAktIRAKJNKToll-like Receptor (TLR)ERKCalcium ChannelKcsANuclear factor-κBNuclear factor-kappaBPKBProtein kinase BInterleukin-1 receptor associated kinaseIL-1R associated kinasec-Jun N-terminal kinaseExtracellular signal regulated kinasesCa2+ channelsCa channelsA2780A2780-SPHEBSHG44U251U-87Inhibitorinhibitorinhibit

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