2. Cell Cycle/DNA Damage TGF-beta/Smad Stem Cell/Wnt Cytoskeleton
  3. LIM Kinase (LIMK) ROCK PKA
  4. LX7101 monohydrochloride

LX7101 monohydrochloride is a potent LIM-kinase, ROCK and PKA inhibitor with IC50s of 24 nM, 1.6 nM, 10 nM and <1 nM for LIMK1, LIMK2, ROCK2 and PKA, respectively. LX7101 monohydrochloride proves significantly selective for LIMK2 with IC50 values of 4.3 nM and 32 nM for LIMK2 and LIMK1 at 2 μM ATP, respectively. LX7101 monohydrochloride has the potential for ocular hypertension and associated glaucoma research.

For research use only. We do not sell to patients.

LX7101 monohydrochloride

LX7101 monohydrochloride Chemical Structure

CAS No. : 2319882-48-7

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LX7101 monohydrochloride Related Antibodies

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Proliferation Assay

    LX7101 monohydrochloride purchased from MedChemExpress. Usage Cited in: Oncogene. 2023 May;42(18):1478-1491.  [Abstract]

    Both LX7101 (5 μM) and TH-257 (5 μM) inhibits the colony-forming ability of melanoma cells (A375-MA2, MeWo, and SK-MEL-147 cells) in soft-agar.

    LX7101 monohydrochloride purchased from MedChemExpress. Usage Cited in: Oncogene. 2023 May;42(18):1478-1491.  [Abstract]

    Both LX7101 (5 μM; 24 h) and TH-257 (5 μM; 24 h) reduces the phosphorylation of G3BP1 in A375-MA2 and SK-MEL-147 cells.

    LX7101 monohydrochloride purchased from MedChemExpress. Usage Cited in: Sci Rep. 2018 Aug 2;8(1):11585.  [Abstract]

    Western blot analysis of GFAP protein levels in LX7101 and DMSO-treated iNPC-KO lines. GAPDH is used as a loading control.

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    LIMK1 LIMK2

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    ROCK ROCK1 ROCK2

    View All PKA Isoform Specific Products:

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    PKA PKAR PKACα

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    • Customer Review

    Description

    LX7101 monohydrochloride is a potent LIM-kinase, ROCK and PKA inhibitor with IC50s of 24 nM, 1.6 nM, 10 nM and <1 nM for LIMK1, LIMK2, ROCK2 and PKA, respectively. LX7101 monohydrochloride proves significantly selective for LIMK2 with IC50 values of 4.3 nM and 32 nM for LIMK2 and LIMK1 at 2 μM ATP, respectively. LX7101 monohydrochloride has the potential for ocular hypertension and associated glaucoma research[1][2].

    IC50 & Target[1]

    LIMK1

    24 nM (IC50)

    LIMK2

    1.6 nM (IC50)

    ROCK2

    10 nM (IC50)

    PKA

    <1 nM (IC50)

    In Vivo

    LX7101 (200 μg/40 μL eye drop) monohydrochloride displays a significant intraocular pressure (IOP) reduction at time points ranging from 1 h to 6 h post administration in ocular normotensive New Zealand White (NZW) rabbits[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    Molecular Weight

    487.98

    Formula

    C23H30ClN7O3
    CAS No.
    SMILES

    NCC1(C(NC2=CC(OC(N(C)C)=O)=CC=C2)=O)CCN(C3=C4C(NC=C4C)=NC=N3)CC1.Cl
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    LX7101 monohydrochloride Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    LX7101 monohydrochloride2319882-48-7LIM Kinase (LIMK)ROCKPKALIMKsRho-associated protein kinaseRho-associated kinaseRho-kinaseROKProtein kinase Aocular hypertensionglaucomaInhibitorinhibitorinhibit

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