1-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone

Name: 1-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone
Brand: MedChemExpress
SKU: HY-W012383
Rating: 4.5 (1 reviews)

Cat. No.: HY-W012383 Purity: 99.86%: Data Sheet
SDS

COA
Handling Instructions
FAQs
Technical Support

1-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

For research use only. We do not sell to patients.

1-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone Chemical Structure

CAS No. : 86404-63-9

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Free Sample (0.1 - 0.5 mg)	Apply Now
100 g	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Other Forms of 1-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone:

1-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone (Standard) Get quote

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Biological Activity
Purity & Documentation
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Description

1-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Cellular Effect

Cell Line	Type	Value	Description	References
U2OS	EC₅₀	144 μM Compound: 6	Antitrypanosomal activity against amastigote stage of Trypanosoma cruzi Y infected in human U2OS cells after 96 hrs by Draq5 staining-based high content screening assay Antitrypanosomal activity against amastigote stage of Trypanosoma cruzi Y infected in human U2OS cells after 96 hrs by Draq5 staining-based high content screening assay	[PMID: 27318979]

Molecular Weight

223.18

Formula

C₁₀H₇F₂N₃O

CAS No.

86404-63-9

Appearance

Solid

Color

White to yellow

SMILES

FC1=CC=C(C(CN2N=CN=C2)=O)C(F)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 200 mg/mL (896.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.4807 mL	22.4034 mL	44.8069 mL
5 mM	0.8961 mL	4.4807 mL	8.9614 mL
10 mM	0.4481 mL	2.2403 mL	4.4807 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (22.40 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (22.40 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 5 mg/mL (22.40 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.86%

Select Batch:

Data Sheet (243 KB) SDS (393 KB)

COA (247 KB) HNMR (122 KB) RP-HPLC (217 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.4807 mL	22.4034 mL	44.8069 mL	112.0172 mL
	5 mM	0.8961 mL	4.4807 mL	8.9614 mL	22.4034 mL
	10 mM	0.4481 mL	2.2403 mL	4.4807 mL	11.2017 mL
	15 mM	0.2987 mL	1.4936 mL	2.9871 mL	7.4678 mL
	20 mM	0.2240 mL	1.1202 mL	2.2403 mL	5.6009 mL
	25 mM	0.1792 mL	0.8961 mL	1.7923 mL	4.4807 mL
	30 mM	0.1494 mL	0.7468 mL	1.4936 mL	3.7339 mL
	40 mM	0.1120 mL	0.5601 mL	1.1202 mL	2.8004 mL
	50 mM	0.0896 mL	0.4481 mL	0.8961 mL	2.2403 mL
	60 mM	0.0747 mL	0.3734 mL	0.7468 mL	1.8670 mL
	80 mM	0.0560 mL	0.2800 mL	0.5601 mL	1.4002 mL
	100 mM	0.0448 mL	0.2240 mL	0.4481 mL	1.1202 mL