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cancer,cell

" in MedChemExpress (MCE) Product Catalog:

2796

Inhibitors & Agonists

11

Screening Libraries

19

Fluorescent Dye

32

Biochemical Assay Reagents

104

Peptides

24

Inhibitory Antibodies

570

Natural
Products

1

Recombinant Proteins

78

Isotope-Labeled Compounds

16

Click Chemistry

30

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-127079
    Epothilone F

    		Microtubule/Tubulin Cancer
    Epothilone F is a Microtubule/Tubulin-stabilizing agent with anti-tumor activity. Epothilone F inhibits the proliferation of breast cancer cells, non-small cell lung cancer cells, drug-resistant ovarian cancer cells .
    Epothilone F
  • HY-N9534
    Xylopine

    		Reactive Oxygen Species Apoptosis Cancer
    Xylopine is an aporphine alkaloid with cytotoxic activity on cancer cells. Xylopine induces oxidative stress, causes G2/M cell cycle arrest and apoptosis in cancer cells .
    Xylopine
  • HY-N2732
    6-Prenylapigenin

    6-Prenyl-4',5,7-trihydroxyflavone; 6-C-Prenylapigenin

    		 Others Cancer
    6-Prenylapigenin is a biologically active flavonoid with anti-tumor activity and antiangiogenic properties. 6-Prenylapigenin exerts cytotoxicity against cancer cells, such as leukemia and solid cancer cells .
    6-Prenylapigenin
  • HY-146170
    Anticancer agent 69

    		Reactive Oxygen Species EGFR Apoptosis Cancer
    Anticancer agent 69 (Compound 34), a potent and selective anticancer agent , potently and selectively inhibits human prostate cancer cell line PC3 (IC50=26 nM). Anticancer agent 69 increases ROS level, down-regulates EGFR and induces apoptosis .
    Anticancer agent 69
  • HY-153519
    WWL0245

    		Epigenetic Reader Domain Cancer
    WWL0245 is a potent and seletive BRD4 PROTAC. WWL0245 selectively degrades BRD4 with sub-nanomolar DC50 (<1 nM) than BRD2/3 and PLK1 ( DC50>1 μM). WWL0245 shows excellent selective cytotoxicity in the BETi sensitive cancer cell lines, including AR-positive prostate cancer cell lines. WWL0245 is a promising drug candidate for AR-positive prostate cancer research and a valuable tool compound to study the biological function of BRD4 .
    WWL0245
  • HY-N2877
    Annonacin

    		Potassium Channel Sodium Channel Na+/K+ ATPase Calcium Channel Apoptosis Neurological Disease Cancer
    Annonacin is an acetylgenin that is toxic by inhibiting the pathway of the mitochondrial complex. Annonacin increases tau phosphorylation in R406W +/+ mice. Annonacin acts as an inhibitor of the sodium/potassium and sarcoplasmic reticulum (SERCA) ATPase pumps. Annonacin has significant killing effect on ovarian cancer cell, cervical cancer cell, breast cancer cell, bladder cancer cell and skin cancer cell. Annonacin induces apoptosis through Bax and Caspase-3-related pathways .
    Annonacin
  • HY-117429
    Se-Aspirin

    Selenium-acetylsalicylic acid

    		 NF-κB Inflammation/Immunology
    Se-Aspirin is a hybrid molecule of selenium and Aspirin (HY-14654). Se-Aspirin reduces the viability of cancer cell lines, particularly colorectal cancer cells .
    Se-Aspirin
  • HY-N3446
    IVHD-valtrate

    		Apoptosis Cancer
    IVHD-valtrate, an active Valeriana jatamansi derivative, is against human ovarian cancer cells in vitro and in vivo. IVHD-valtrate induces cancer cells apoptosis and arrests the ovarian cancer cells in the G2/M phase. IVHD-valtrate has the potential to be a novel chemotherapeutic agent for the human ovarian cancer research .
    IVHD-valtrate
  • HY-N10304
    Isodispar B

    		Apoptosis Cancer
    Isodispar B is an anticancer agent that inhibits the proliferation of nasopharyngeal carcinoma and breast cancer cells and induces cell apoptosis. Isodispar B is cytotoxic to a wide range of cancer cell lines .
    Isodispar B
  • HY-121588
    IMTPPE

    		Adrenergic Receptor Cancer
    IMTPPE is an inhibitor of the androgen receptor (AR) in C4-2 prostate cancer cells, inhibiting its transcriptional activity and protein levels. IMTPPE inhibited the proliferation of AR-positive prostate cancer cells but had no effect on AR-negative prostate cancer cells. IMTPPE also inhibited the growth of enzalutamide-resistant 22Rv1 xenograft tumors .
    IMTPPE
  • HY-N1039A
    Manool

    		Others Cancer
    Manool is a diterpene from Salvia officinalis. Manool induces selective cytotoxicity in cancer cells. Manool arrests the cancer cells at the G(2)/M phase of the cell cycle .
    Manool
  • HY-N10563
    Coleon-U-quinone

    		P-glycoprotein Cancer
    Coleon-U-quinone is a potent P-gp inhibitor. Coleon-U-quinone can inhibit cancer cells viability and sensitize multidrug resistance cancer cells to Doxorubicin (HY-15142A) .
    Coleon-U-quinone
  • HY-136383
    AZA1
    1 Publications Verification

    Rac1/Cdc42-IN-1

    		 Ras Apoptosis Cancer
    AZA1 is a potent dual inhibitor of Rac1 and Cdc42. AZA1 induces prostate cancer cells apoptosis and inhibits prostate cancer cells proliferation, migration and invasion .
    AZA1
  • HY-N14618
    Rhodomycin A

    		Src Cancer
    Rhodomycin A can suppress lung cancer cell progression via modulating Src-related pathways.?Rhodomycin A significantly suppressed cancer cell proliferation, migration, invasion, and clonogenicity in vitro and tumour growth in vivo .
    Rhodomycin A
  • HY-N1988
    Cucurbitacin IIa

    Hemslecin A

    		 Survivin Apoptosis Cancer
    Cucurbitacin IIa is a triterpene isolated from Hemsleya amalils Diels, induces apoptosis of cancer cells, reduces expression of survivin, reduces phospho-Histone H3 and increases cleaved PARP in cancer cells .
    Cucurbitacin IIa
  • HY-N9954
    Isoharringtonine

    		Apoptosis Cancer
    Isoharringtonine is a natural alkaloid that can be purified from Cephalotaxus koreana Nakai. Isoharringtonine can inhibit cancer cell proliferation and migration, and induce cancer cell apoptosis. Isoharringtonine can be used for the research of cancers .
    Isoharringtonine
  • HY-164033
    HOE 689

    Ramnodigin

    		 Apoptosis Cancer
    HOE 689 (Ramnodigin) is an analog of Digitoxin (HY-B1357). HOE 689 exhibits cytotoxicity to lung cancer cells and induces apoptosis in cancer cell NCI-H460 with an IC50 of 52 nM .
    HOE 689
  • HY-170366
    VEGFR-2-IN-58

    		VEGFR Apoptosis Cancer
    VEGFR-2-IN-58 (Compound 7b) inhibits VEGFR-2 with an IC50 of 42.5 nM. VEGFR-2-IN-58 displays selective cytotoxicity against cancer cells. VEGFR-2-IN-58 shows cellular growth arrest at the G2/M phase in cancer cells. VEGFR-2-IN-58 induces cancer cells Apoptosis, increasing BAX expression and reducing Bcl2 expression. VEGFR-2-IN-58 inhibits wound closure in cancer cells .
    VEGFR-2-IN-58
  • HY-15694
    SMIP004
    4 Publications Verification

    		 E1/E2/E3 Enzyme Apoptosis Cancer
    SMIP004 is a SKP2 E3 ligase inhibitor, which downregulates SKP2 and to stabilise p27. SMIP004 is a cancer cell selective apoptosis inducer of human prostate cancer cells .
    SMIP004
  • HY-155023
    Apoptosis inducer 13

    		Apoptosis Reactive Oxygen Species Cancer
    Apoptosis inducer 13 (Compound Ru4) can induce cancer cell apoptosis, and inhibits cancer cell migration and invasion. Apoptosis inducer 13 converts coenzyme NADH to NAD +, and increases intracellular ROS levels .
    Apoptosis inducer 13
  • HY-N14738
    Dutomycin

    		Serpin Autophagy Apoptosis Cancer
    Dutomycin is a SERPINB6 inhibitor with a binding constant (KD) of 1.236 μM. Dutomycin can induce autophagy and apoptosis in cancer cells and inhibit the growth of cancer cells in a zebrafish xenograft model. Dutomycin is promising for research of cancers .
    Dutomycin
  • HY-N15297
    Isotenulin

    		P-glycoprotein Cancer
    Isotenulin inhibits the efflux function of P-glycoprotein by stimulation of P-glycoprotein ATPase, thereby overcoming the multidrug resistance (MDR) of cancer cells. Isotenulin exhibits cytotoxicity in multidrug-resistant cancer cell KB-vin and sensitive cancer cell HeLaS3. Isotenulin exhibits synergistic effect with Paclitaxel (HY-B0015), Vinblastine (HY-13780) and Doxorubicin (HY-15142) .
    Isotenulin
  • HY-N12142
    Anticancer agent 156

    		Others Cancer
    Anticancer agent 156 (compound 11) is a powerful anticancer agent based on Miliusanes (anticancer lead molecule). Anticancer agent 156 effectively inhibits the growth of human cancer cells and shows significant cytotoxicity to gastric cancer cells .
    Anticancer agent 156
  • HY-149076
    hGAPDH-IN-1

    		Drug Derivative Cancer
    hGAPDH-IN-1, a 3-bromo-4,5-dihydroisoxazole derivative, is a specific and potent hGAPDH covalent inhibitor. hGAPDH-IN-1 reduces cancer cell growth in different pancreatic cancer cell lines.
    hGAPDH-IN-1
  • HY-108992
    Deoxynyboquinone

    		Quinone Reductase Apoptosis Reactive Oxygen Species Cancer
    Deoxynyboquinone, an excellent NQO1 substrate, is a potent antineoplastic agent. Deoxynyboquinone induces apoptosis in cancer cell lines. Deoxynyboquinone kills cancer cells through oxidative stress and reactive oxygen species (ROS) formation .
    Deoxynyboquinone
  • HY-120069
    APX2009

    		Apoptosis Cancer
    APX2009 is a specific APE1/REF-1 redox inhibitor with anticancer activities which decreases the proliferative, migratory, and invasive properties of breast cancer cell and induces apoptosis in breast cancer cell .
    APX2009
  • HY-153401
    Topoisomerase II inhibitor 13

    		Topoisomerase Cancer
    Topoisomerase II inhibitor 13 is a topoisomerase II (Topo II) inhibitor. Topoisomerase II inhibitor 13 shows antiproliferative activity against several cancer cells. Topoisomerase II inhibitor 13 induces cancer cells apoptosis .
    Topoisomerase II inhibitor 13
  • HY-P10669
    NDI-Lyso

    		Caspase Apoptosis Cancer
    NDI-Lyso is a lysosome-targeted anticancer agent that induces the formation of rigid long fibers in cancer cell lysosomes through an enzyme-instructed self-assembly (EISA) mechanism catalyzed by cathepsin B. This process triggers lysosomal swelling, membrane permeabilization (LMP), and membrane disruption, ultimately leading to cancer cell apoptosis via a non-classical caspase-independent pathway. NDI-Lyso exhibits significant selective anticancer activity in various cancer cell lines and drug-resistant cancer cells (IC50 ~10 μM) while showing low toxicity to normal cells (IC50 > 60 μM) .
    NDI-Lyso
  • HY-N11067
    Taccalonolide E

    		Apoptosis Cancer
    Taccalonolide E is a microtubule stabilizer and induces cancer cell apoptosis.
    Taccalonolide E
  • HY-169477
    PAMAM dendrimer G0.5 carboxylate sodium

    		Biochemical Assay Reagents Cancer
    PAMAM Dendrimer G0.5 Carboxylate sodium is a polyamidoamine (PAMAM) dendrimer with carboxylate termini. PAMAM Dendrimer G0.5 Carboxylate sodium conjugated with DACHPt is cytotoxic to A2780 ovarian cancer cells, MCF-7 breast cancer cells, Caco-2 colon cancer cells and BJ fibroblasts with IC50 values of 0.03, 1.6, 0.18 and 3 µM, respectively .
    PAMAM dendrimer G0.5 carboxylate sodium
  • HY-144655
    IP2

    		Phosphatase Cancer
    IP2 is an immunomodulatory agent. IP2 increases PTP (Pioneer Translation Product)-derived antigen presentation in cancer cells. IP2 shows non-cytotoxic for cancer cells. IP2 induces tumor growth defects in mouse .
    IP2
  • HY-139825
    Indoluidin E

    		Dihydroorotate Dehydrogenase Cancer
    Indoluidin E selectively inhibits DHODH and suppresses cancer cell growth.
    Indoluidin E
  • HY-W395613
    TY-011

    		Aurora Kinase Cancer
    TY-011 is an Aurora A/B kinase inhibitor. TY-011 induces abnormal microtubule-kinetochore attachment, leading to DNA damage and apoptosis (Apoptosis) in human gastric cancer cells, and ultimately inhibits cancer cell proliferation, with an IC50 value ranging from 0.11 to 4.49 μM in human gastric cancer cell lines. TY-011 has potential applications in gastric cancer research .
    TY-011
  • HY-119616
    Phenamet

    		Apoptosis Cancer
    Phenamet is an anti-tumor agent that can inhibit tumor growth and slow the progression of cancer. Phenamet prevents the reproduction of tumor cells by interfering with the growth and division of cancer cells. In addition, Phenamet can induce apoptosis in cancer cells, thereby eliminating tumor cells.
    Phenamet
  • HY-153588
    HSP90-IN-22

    		HSP Cancer
    HSP90-IN-22 (Compound 35) is an Hsp90 inhibitor with antiproliferative properties on cells with IC50 values of 3.65 μM for MCF7 breast cancer cells and 2.71 μM for SKBr3 breast cancer cells, respectively.
    HSP90-IN-22
  • HY-123901
    Garcinone E

    		Apoptosis Cancer
    Garcinone E is a natural xanthone found in the rind of the mangosteen fruit. Garcinone E induces apoptosis and inhibits cancer cell migration. Garcinone E has anticancer effects on different human cancer cell lines, including colorectal, breast, and hepatocellular carcinomas .
    Garcinone E
  • HY-N13139
    Dexylosyltubeimoside Ⅲ

    		Others Cancer
    Dexylosyltubeimoside Ⅲ (compound 3) is a cyclic disoside that can be isolated from Actinostemma lobatum MAXIM. Dexylosyltubeimoside Ⅲ has in vitro anticancer activity and inhibits the growth of human esophageal cancer cell line ECA109 (IC50=22.37 μM), lung cancer cell line A549 (IC50=27.27 μM) and gastric cancer cell line MGC-803 (IC50=36.85 μM) .
    Dexylosyltubeimoside Ⅲ
  • HY-N13213
    Fenugreek Seed Extract

    		Others Cancer
    Fenugreek Seed Extract is a fenugreek extract. Fenugreek Seed Extract has potential antibacterial and anticancer activities, can inhibit Staphylococcus aureus and Pseudomonas aeruginosa, and inhibit the proliferation of MCF-7 breast cancer cells (no significant effect on liver cancer cells). .
    Fenugreek Seed Extract
  • HY-147081
    AS 1411

    AGRO-100

    		 Histone Methyltransferase Bcl-2 Family Cancer
    AS 1411 (AGRO-100) is an oligonucleotide aptamer targeting nucleoproteins. AS 1411 inhibits tumor cell proliferation by affecting the activity of nucleoprotein-containing complexes and can be used as a carrier to precisely deliver nanoparticles, oligonucleotides and small molecules to cancer cells. AS 1411 reduces PRMT5 expression to inhibit tumor growth in DU145 prostate cancer cells. AS 1411 works by blocking the binding of nucleoproteins to bcl-2 mRNA in MCF-7 breast cancer cells. AS 1411-coupled Jin nanospheres can inhibit breast cancer cell proliferation in vitro and in mouse models, has the ability to cross the blood-brain barrier with low tissue toxicity .
    AS 1411
  • HY-21972
    BCI-121
    4 Publications Verification

    		 Histone Methyltransferase Cancer
    BCI-121 is a SMYD3 inhibitor that impairs the proliferation of cancer cell.
    BCI-121
  • HY-152147
    SZUH280

    		PROTACs HDAC Apoptosis DNA/RNA Synthesis Cancer
    SZUH280 is a potent and selective PROTAC HDAC8 degrader with a DC50 of 0.58 μM in A549 cells. SZUH280 induces cancer cell apoptosis. SZUH280 hampers DNA damage repair in cancer cells, promoting cellular radiosensitization .
    SZUH280
  • HY-125900
    Neocarzilin A

    NCA

    		 Others Cancer
    Neocarzilin A (NCA) reduces BST-2 levels via lysosomal degradation. Neocarzilin A has antimigratory and antiproliferative effects on cancer cells. Neocarzilin A inhibits cancer cell migration via irreversible binding to the synaptic vesicle membrane protein VAT-1 .
    Neocarzilin A
  • HY-14590
    Kaempferol
    40+ Cited Publications

    Kempferol; Robigenin

    		 Estrogen Receptor/ERR Autophagy Mitophagy Apoptosis HIV Parasite Endogenous Metabolite Cancer
    Kaempferol (Kempferol), a flavonoid found in many edible plants, inhibits estrogen receptor α expression in breast cancer cells and induces apoptosis in glioblastoma cells and lung cancer cells by activation of MEK-MAPK. Kaempferol can be uesd for the research of breast cancer .
    Kaempferol
  • HY-122185
    Anticancer agent 211

    		Apoptosis Microtubule/Tubulin Cancer
    Anticancer agent 211 (AK301) can inhibit tubulin polymerization. Anticancer agent 211 can block the division of human colon cancer cells. Anticancer agent 211 can increase the sensitivity of human colon cancer cells to apoptotic ligands and promote cell apoptosis .
    Anticancer agent 211
  • HY-149231
    Anticancer agent 104

    		Apoptosis Cancer
    Anticancer agent 104 has anticancer activity, and induces cancer cell apoptosis .
    Anticancer agent 104
  • HY-N11644
    Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid

    		Others Cancer
    Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid, also known as ganoderic acid 24. Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid shows high cytotoxicity against cancer cells, such as human lung cancer cells CH27, melanoma cells M21, and oral cancer cells HSC-3 .
    Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid
  • HY-172449
    GLI1-IN-3

    		Hedgehog Cancer
    GLI1-IN-3 (Compound 11a), a triterpenoid analogue, can inhibit Hedgehog signaling in GLI1 overexpression cancer cells. GLI1-IN-3 inhibits the proliferation in NSCLC and prostate cancer cell lines exhibiting hyper-activated Hh signaling. GLI1-IN-3 can also decrease the expression of endogenous GLI1 protein and its target genes associated with tumor progression and proliferation in A549 and DU-145 cancer cells .
    GLI1-IN-3
  • HY-162796
    TS-2

    		Apoptosis G-quadruplex c-Myc Cancer
    TS-2 is a fluorescent ligand of c-Myc G4 with anticancer activity. TS-2 inhibits the growth of cancer cells and induces apoptosis of cancer cells by targeting the c-MYC oncogene promoter G4, causing transcriptional repression of the c-Myc oncogene .
    TS-2
  • HY-160699
    DCC-3116

    		ULK Ras Autophagy Cancer
    DCC-3116 is an orally active ULK1/2 inhibitor. DCC-3116 can inhibit autophagy in lung cancer cells by inhibiting KRAS G12C signaling, thereby inhibiting the proliferation of lung cancer cells and exerting anti-cancer effects .
    DCC-3116
  • HY-153873
    MSU38225

    		Keap1-Nrf2 Reactive Oxygen Species Cancer
    MSU38225 is an Nrf-2 inhibitor that increases levels of reactive oxygen species (ROS). MSU38225 inhibits the growth of human lung cancer cells and enhances the sensitivity of human lung cancer cells to chemotherapy in vitro and in vivo. MSU38225 can be used in cancer research .
    MSU38225

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