EG00229

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EG00229 is an inhibitor for VEGF-A and NRP1 interaction with an IC₅₀ of 8 μM. EG00229 inhibits the migration of HUVECS and the phosphorylation of VEGFR2 in endothelial cells. EG00229 exhibits cytotoxicity in cancer cell A549.

For research use only. We do not sell to patients.

EG00229 Chemical Structure

CAS No. : 1018927-63-3

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Other In-stock Forms of EG00229:

EG00229 trifluoroacetate

Other Forms of EG00229:

EG00229 trifluoroacetate In-stock

8 Publications Citing Use of MCE EG00229

Proliferation Assay

: EG00229 purchased from MedChemExpress. Usage Cited in: Cell Physiol Biochem. 2017;44(3):1251-1262. [Abstract]; The inhibitor of NRP-1 called EG00229 decreases sphere and clone formation in MDA-MB-231 cells.

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Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	11.1 μM Compound: EG00229	Inhibition of recombinant human biotinylated VEGF-165A expressed in HEK293 cells binding to immobilized recombinant full length human FC-tagged NRP1 (chimera active) expressed in HEK293 cells using TMB as substrate incubated for 2 hrs followed by substrat Inhibition of recombinant human biotinylated VEGF-165A expressed in HEK293 cells binding to immobilized recombinant full length human FC-tagged NRP1 (chimera active) expressed in HEK293 cells using TMB as substrate incubated for 2 hrs followed by substrat	[PMID: 31744780]

Molecular Weight

497.57

Formula

C₁₇H₁₉N₇O₅S₃

CAS No.

1018927-63-3

SMILES

N=C(N)NCCC[C@@H](C(O)=O)NC(C1=C(NS(=O)(C2=CC=CC3=NSN=C32)=O)C=CS1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Jarvis A, et al., Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction. J Med Chem. 2010 Mar 11;53(5):2215-26. [Content Brief]

EG00229 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EG002291018927-63-3EG 00229EG-00229VEGFRVascular endothelial growth factor receptorA549DU145HUVECslung cancerprostate carcinomaInhibitorinhibitorinhibit

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