A-1293201

Cat. No.: HY-125147 Purity: 99.82%: Data Sheet
COA

SDS
Handling Instructions
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A-1293201 is a substrate-independent NAMPT inhibitor with antitumor activity. A-1293201 effectively reduces the total cellular NAD⁺/NADH (NADt) level, subsequently leading to ATP depletion and cancer cell death. In addition, A-1293201 can effectively overcome the acquired resistance mechanism of the NAMPT Y18 mutant to CHS-828 (HY-10079).

For research use only. We do not sell to patients.

A-1293201 Chemical Structure

CAS No. : 1375557-33-7

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Description

Cellular Effect

Cell Line	Type	Value	Description	References
PC-3	IC₅₀	56 nM Compound: 58	Antiproliferative activity against human PC3 cells assessed as reduction in cell viability incubated for 5 days by Cell-titer Glo reagent based assay Antiproliferative activity against human PC3 cells assessed as reduction in cell viability incubated for 5 days by Cell-titer Glo reagent based assay	[PMID: 28610984]

Molecular Weight

365.43

Formula

C₂₁H₂₃N₃O₃

CAS No.

1375557-33-7

Appearance

Solid

Color

White to off-white

SMILES

O=C(N1CC2=C(C=CC=C2)C1)NC3=CC=C(C(NC[C@H]4COCC4)=O)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 62.5 mg/mL (171.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7365 mL	13.6825 mL	27.3650 mL
5 mM	0.5473 mL	2.7365 mL	5.4730 mL
10 mM	0.2737 mL	1.3683 mL	2.7365 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

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Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.82%

Select Batch:

Data Sheet (270 KB) SDS (251 KB)

COA (247 KB) HNMR (289 KB) LCMS (101 KB)

Handling Instructions (2659 KB)

References

[1]. Jun Guo, et al. "Identification of novel resistance mechanisms to NAMPT inhibition via the de novo NAD+ biosynthesis pathway and NAMPT mutation." Biochemical and biophysical research communications 491.3 (2017): 681-686. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7365 mL	13.6825 mL	27.3650 mL	68.4126 mL
	5 mM	0.5473 mL	2.7365 mL	5.4730 mL	13.6825 mL
	10 mM	0.2737 mL	1.3683 mL	2.7365 mL	6.8413 mL
	15 mM	0.1824 mL	0.9122 mL	1.8243 mL	4.5608 mL
	20 mM	0.1368 mL	0.6841 mL	1.3683 mL	3.4206 mL
	25 mM	0.1095 mL	0.5473 mL	1.0946 mL	2.7365 mL
	30 mM	0.0912 mL	0.4561 mL	0.9122 mL	2.2804 mL
	40 mM	0.0684 mL	0.3421 mL	0.6841 mL	1.7103 mL
	50 mM	0.0547 mL	0.2737 mL	0.5473 mL	1.3683 mL
	60 mM	0.0456 mL	0.2280 mL	0.4561 mL	1.1402 mL
	80 mM	0.0342 mL	0.1710 mL	0.3421 mL	0.8552 mL
	100 mM	0.0274 mL	0.1368 mL	0.2737 mL	0.6841 mL

A-1293201 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

A-12932011375557-33-7A1293201A 1293201NAMPTNicotinamide phosphoribosyl transferasePBEFVisfatinpre-B cell-enhancing factorPre-B cell colony enhancing factorAnti-tumorinhibitorATPdrug resistanceInhibitorinhibit

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A-1293201

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