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PROTAC erf3a Degrader-1 

Cat. No.: HY-163938 Purity: 99.44% ee.: 100.00%
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PROTAC erf3a Degrader-1 (Compound C63) is an orally active PROTAC erf3a Degrader. PROTAC erf3a Degrader-1 inhibits cancer cell proliferation (eg: 22Rv1). PROTAC erf3a Degrader-1 can be used for research of prostate cancer, ovarian cancer, liver cancer, cervical cancer, leukemia, breast cancer. (Red: erf3a ligand (HY-13778); Black: linker (HY-163960); Blue: CRBN ligand (HY-41547)).

For research use only. We do not sell to patients.

PROTAC erf3a Degrader-1

PROTAC erf3a Degrader-1 Chemical Structure

CAS No. : 3033871-19-8

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Other Forms of PROTAC erf3a Degrader-1:

PROTAC erf3a Degrader-1 Related Antibodies

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Description

PROTAC erf3a Degrader-1 (Compound C63) is an orally active PROTAC erf3a Degrader. PROTAC erf3a Degrader-1 inhibits cancer cell proliferation (eg: 22Rv1). PROTAC erf3a Degrader-1 can be used for research of prostate cancer, ovarian cancer, liver cancer, cervical cancer, leukemia, breast cancer. (Red: erf3a ligand (HY-13778); Black: linker (HY-163960); Blue: CRBN ligand (HY-41547))[1].

Molecular Weight

760.92

Formula

C44H52N6O6
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N1[C@@H]2C(NC(CC2)=O)=O)C3=CC=CC(N[C@H](CCC4)C[C@@H]4NC5=CC(NC([C@H]6CC[C@]([C@@]7([H])[C@@](CC8)([H])[C@@]9([C@@](NC(C=C9)=O)([H])CC7)C)([H])[C@]86C)=O)=CC=C5)=C3C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 60 mg/mL (78.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3142 mL 6.5710 mL 13.1420 mL
5 mM 0.2628 mL 1.3142 mL 2.6284 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3142 mL 6.5710 mL 13.1420 mL 32.8550 mL
5 mM 0.2628 mL 1.3142 mL 2.6284 mL 6.5710 mL
10 mM 0.1314 mL 0.6571 mL 1.3142 mL 3.2855 mL
15 mM 0.0876 mL 0.4381 mL 0.8761 mL 2.1903 mL
20 mM 0.0657 mL 0.3285 mL 0.6571 mL 1.6427 mL
25 mM 0.0526 mL 0.2628 mL 0.5257 mL 1.3142 mL
30 mM 0.0438 mL 0.2190 mL 0.4381 mL 1.0952 mL
40 mM 0.0329 mL 0.1643 mL 0.3285 mL 0.8214 mL
50 mM 0.0263 mL 0.1314 mL 0.2628 mL 0.6571 mL
60 mM 0.0219 mL 0.1095 mL 0.2190 mL 0.5476 mL
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PROTAC erf3a Degrader-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC erf3a Degrader-13033871-19-8PROTACsprostate cancerovarian cancerliver cancercervical cancerleukemiabreast cancerInhibitorinhibitorinhibit

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