2. Epigenetics PI3K/Akt/mTOR Apoptosis NF-κB
  3. AMPK Apoptosis NF-κB TNF Receptor
  4. Candidusin A

Candidusin A (CHNQD-0803) (Compound 4) is a AMPK activator with a KD of 47.28 nM. Candidusin A can be isolated from marine fungus Aspergillus candidus. Candidusin A has cytotoxic activity and induces apoptosis in human prostate cancer cells (22Rv1, PC-3 and LNCaP cells). Candidusin A reduces adipogenesis genes expression and fat deposition, negatively regulates the NF-κB-TNFα inflammatory axis to suppress inflammation, and ameliorates liver injury and fibrosis. Candidusin A can be used for non-alcoholic steatohepatitis (NASH) research.

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Candidusin A

Candidusin A Chemical Structure

CAS No. : 81474-59-1

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Candidusin A Related Antibodies

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Description

Candidusin A (CHNQD-0803) (Compound 4) is a AMPK activator with a KD of 47.28 nM. Candidusin A can be isolated from marine fungus Aspergillus candidus. Candidusin A has cytotoxic activity and induces apoptosis in human prostate cancer cells (22Rv1, PC-3 and LNCaP cells). Candidusin A reduces adipogenesis genes expression and fat deposition, negatively regulates the NF-κB-TNFα inflammatory axis to suppress inflammation, and ameliorates liver injury and fibrosis. Candidusin A can be used for non-alcoholic steatohepatitis (NASH) research[1][2].

Molecular Weight

352.34

Formula

C20H16O6
CAS No.
SMILES

OC1=CC=C(C2=CC(OC)=C3C(OC4=CC(O)=C(C=C43)O)=C2OC)C=C1
Structure Classification
Initial Source

Aspergillus candidus
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Candidusin A Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Candidusin A81474-59-1CHNQD-0803CHNQD0803CHNQD 0803AMPKApoptosisNF-κBTNF ReceptorAMP-activated protein kinaseNuclear factor-κBNuclear factor-kappaBTumor Necrosis Factor ReceptorTNFRActivatorAspergillus candidusCytotoxic22Rv1 cellsPC-3 cellsLNCaP cellsNF-κB-TNFαNon-alcoholic steatohepatitisNASHInhibitorinhibitorinhibit

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