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  4. Glucoraphasatin potassium

Glucoraphasatin (potassium) is potassium salt of Glucoraphasatin (HY-N11822). Glucoraphasatin is an atypical and orally active glucosinolate found in cruciferous vegetables, including Raphanus sativus. Glucoraphasatin exhibits anti-inflammation and anti-oxidant activity. Glucoraphasatin can affect phase I metabolic enzymes activity. Glucoraphasatin can be converted by the plant enzyme myrosinase into isothiocyanates and shows cytotoxic to cancer cells. Glucoraphasatin can be used for the researches of cancer and inflammation, such as colon cancer.

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Glucoraphasatin potassium

Glucoraphasatin potassium Chemical Structure

CAS No. : 245550-64-5

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Glucoraphasatin potassium Related Antibodies

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Description

Glucoraphasatin (potassium) is potassium salt of Glucoraphasatin (HY-N11822). Glucoraphasatin is an atypical and orally active glucosinolate found in cruciferous vegetables, including Raphanus sativus. Glucoraphasatin exhibits anti-inflammation and anti-oxidant activity. Glucoraphasatin can affect phase I metabolic enzymes activity. Glucoraphasatin can be converted by the plant enzyme myrosinase into isothiocyanates and shows cytotoxic to cancer cells. Glucoraphasatin can be used for the researches of cancer and inflammation, such as colon cancer[1][2].

In Vitro

Glucoraphasatin possesses reducing capacity against, both H2O2 and the 2,2’-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) radical cation (ABTS+)[1].
Glucoraphasatin (50 μM, 3-6 days) inhibits proliferation companied with myrosinase in LoVo, HCT-116, and HT-29 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Glucoraphasatin potassium Related Antibodies
In Vivo

Glucoraphasatin (120 mg/kg, p.o., daily for 1 or 4 days) affects phase I metabolic enzymes activity in SD rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SD rats[1]
Dosage: 120 mg/kg
Administration: Orally administration, daily for 1 or 4 days
Result: Resulted in a 2.4-fold increase in CYP3A1/2-linked monooxygenase (aminopyrine N-demethylase) and a 1.6-fold increase in CYP1A2-supported monooxygenase (methoxyresorufin O-demethylase).
Increased CYP1A1-linked monooxygenase (ethoxyresorufin O-deethylase) and the CYP2B1/2-supported oxidase (pentoxyresorufin O-dealkylase) by 1.5-fold.
Reduced CYP2E1-linked monooxygenase (p-nitrophenolhydroxylase) activity.
Molecular Weight

457.58

Formula

C12H20KNO9S3
CAS No.
SMILES

CS/C=C/CC/C(S[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O)CO)=N/OS(=O)(O[K])=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Glucoraphasatin potassium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glucoraphasatin245550-64-5OthersCruciferous vegetablesRaphanus sativusMyrosinaseColon cancerInhibitorinhibitorinhibit

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