3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid (Synonyms: KDN)

Cat. No.: HY-145533 Purity: 99.90%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid (KDN) is a sialic acid. 3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid protects the oligo/(poly)sialyl chains from exosialidases at nonreducing terminal, and plays a role in egg activation of salmonid fish. 3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid is abundant in fetal cord red blood cells and malignant human ovarian cancer cells.

For research use only. We do not sell to patients.

3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid Chemical Structure

CAS No. : 153666-19-4

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Other Forms of 3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid:

3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid sodium In-stock

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Description

3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid (KDN) is a sialic acid. 3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid protects the oligo/(poly)sialyl chains from exosialidases at nonreducing terminal, and plays a role in egg activation of salmonid fish^[1]. 3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid is abundant in fetal cord red blood cells and malignant human ovarian cancer cells^[2].

Molecular Weight

268.22

Formula

C₉H₁₆O₉

CAS No.

153666-19-4

Appearance

Solid

Color

White to off-white

SMILES

OC[C@@H](O)[C@H]([C@]1([H])OC(O)(C[C@@H]([C@H]1O)O)C(O)=O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (372.83 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7283 mL	18.6414 mL	37.2828 mL
5 mM	0.7457 mL	3.7283 mL	7.4566 mL
10 mM	0.3728 mL	1.8641 mL	3.7283 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.90%

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Data Sheet (273 KB) SDS (251 KB)

COA (250 KB)

Handling Instructions (2659 KB)

References

[1]. Nadano D, et al., A naturally occurring deaminated neuraminic acid, 3-deoxy-D-glycero-D-galacto-nonulosonic acid (KDN). Its unique occurrence at the nonreducing ends of oligosialyl chains in polysialoglycoprotein of rainbow trout eggs. J Biol Chem. 1986 Sep 5;261(25):11550-7. [Content Brief]

[2]. Inoue S, et al., Identification of free deaminated sialic acid (2-keto-3-deoxy-D-glycero-D-galacto-nononic acid) in human red blood cells and its elevated expression in fetal cord red blood cells and ovarian cancer cells. J Biol Chem. 1998 Oct 16;273(42):27199-204. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	3.7283 mL	18.6414 mL	37.2828 mL	93.2071 mL
	5 mM	0.7457 mL	3.7283 mL	7.4566 mL	18.6414 mL
	10 mM	0.3728 mL	1.8641 mL	3.7283 mL	9.3207 mL
	15 mM	0.2486 mL	1.2428 mL	2.4855 mL	6.2138 mL
	20 mM	0.1864 mL	0.9321 mL	1.8641 mL	4.6604 mL
	25 mM	0.1491 mL	0.7457 mL	1.4913 mL	3.7283 mL
	30 mM	0.1243 mL	0.6214 mL	1.2428 mL	3.1069 mL
	40 mM	0.0932 mL	0.4660 mL	0.9321 mL	2.3302 mL
	50 mM	0.0746 mL	0.3728 mL	0.7457 mL	1.8641 mL
	60 mM	0.0621 mL	0.3107 mL	0.6214 mL	1.5535 mL
	80 mM	0.0466 mL	0.2330 mL	0.4660 mL	1.1651 mL
	100 mM	0.0373 mL	0.1864 mL	0.3728 mL	0.9321 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid153666-19-4KDNEndogenous Metaboliteovarian cancerantigensalmonid fishInhibitorinhibitorinhibit

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3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid (Synonyms: KDN)

Other Forms of 3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid:

3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid Related Antibodies

Featured Recommendations

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Biological Activity

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References

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