Bizine di(hydrochloride)

Cat. No.: HY-121095A: Data Sheet Handling Instructions
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Bizine dihydrochloride, a Phenelzine analogue, is a potent and selective LSD1 inhibitor, with a b>K_i of 59 nM. Bizine dihydrochloride can modulate bulk histone methylation in cancer cells. Bizine dihydrochloride shows neuroprotective effects.

For research use only. We do not sell to patients.

Bizine di(hydrochloride) Chemical Structure

CAS No. : 1808112-57-3

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Other Forms of Bizine di(hydrochloride):

Bizine Get quote

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•Related Small Molecules:

•Related Proteins:

View All Histone Demethylase Isoform Specific Products:

View All Isoforms

KDM1/LSD1 KDM2 KDM3 KDM4 KDM5 KDM6 KDM7

Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

370.32

Formula

C₁₈H₂₅Cl₂N₃O

CAS No.

1808112-57-3

Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=CC=C(CCNN)C=C1)CCCC2=CC=CC=C2.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (270.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7004 mL	13.5018 mL	27.0037 mL
5 mM	0.5401 mL	2.7004 mL	5.4007 mL
10 mM	0.2700 mL	1.3502 mL	2.7004 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Prusevich P, et, al. A selective phenelzine analogue inhibitor of histone demethylase LSD1. ACS Chem Biol. 2014 Jun 20;9(6):1284-93. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7004 mL	13.5018 mL	27.0037 mL	67.5092 mL
	5 mM	0.5401 mL	2.7004 mL	5.4007 mL	13.5018 mL
	10 mM	0.2700 mL	1.3502 mL	2.7004 mL	6.7509 mL
	15 mM	0.1800 mL	0.9001 mL	1.8002 mL	4.5006 mL
	20 mM	0.1350 mL	0.6751 mL	1.3502 mL	3.3755 mL
	25 mM	0.1080 mL	0.5401 mL	1.0801 mL	2.7004 mL
	30 mM	0.0900 mL	0.4501 mL	0.9001 mL	2.2503 mL
	40 mM	0.0675 mL	0.3375 mL	0.6751 mL	1.6877 mL
	50 mM	0.0540 mL	0.2700 mL	0.5401 mL	1.3502 mL
	60 mM	0.0450 mL	0.2250 mL	0.4501 mL	1.1252 mL
	80 mM	0.0338 mL	0.1688 mL	0.3375 mL	0.8439 mL
	100 mM	0.0270 mL	0.1350 mL	0.2700 mL	0.6751 mL